Molecular mechanisms of kinesin-14 motors in spindle assembly and chromosome segregation

Self-Organization and Forces in the Mitotic Spindle

(2016) Nenad Pavin et al.   Annual Review of Biophysics

Insights into the process of EB1-dependent tip-tracking of kinesin-14 Ncd. The role of the microtubule

(2016) Ewa Szczęsna et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Nuclear Reformation at the End of Mitosis

(2016) Anna Katharina Schellhaus et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis of Backwards Motion in Kinesin-1-Kinesin-14 Chimera: Implication for Kinesin-14 Motility

(2016) Masahiko Yamagishi et al.   STRUCTURE

A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer

(2016) Pavithra L. Chavali et al.   Nature Communications

A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas

(2016) Karuna Mittal et al.   Journal of Ovarian Research

Mechanism for Anaphase B: Evaluation of “Slide-and-Cluster” versus “Slide-and-Flux-or-Elongate” Models

(2015) Ingrid Brust-Mascher et al.   BIOPHYSICAL JOURNAL

The Ran-GTP Gradient Spatially Regulates XCTK2 in the Spindle

(2015) Lesley N. Weaver et al.   CURRENT BIOLOGY

Microtubule Minus-End-Targeting Proteins

(2015) Anna Akhmanova et al.   CURRENT BIOLOGY

Regulatory mechanisms that control mitotic kinesins

(2015) Amber L. Yount et al.   EXPERIMENTAL CELL RESEARCH

Mitosis, microtubule dynamics and the evolution of kinesins

(2015) Juan Jesus Vicente et al.   EXPERIMENTAL CELL RESEARCH

The Msd1–Wdr8–Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies

(2015) Masashi Yukawa et al.   JOURNAL OF CELL BIOLOGY

Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore

(2015) Takashi Akera et al.   NATURE CELL BIOLOGY

DrosophilaNcd reveals an evolutionarily conserved powerstroke mechanism for homodimeric and heterodimeric kinesin-14s

(2015) Pengwei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of kinesin-14 results in aneuploidy via kinesin-5-dependent microtubule protrusions leading to chromosome cut

(2015) Viktoriya Syrovatkina et al.   Nature Communications

Dissecting the Function and Assembly of Acentriolar Microtubule Organizing Centers in Drosophila Cells In Vivo

(2015) Janina Baumbach et al.   PLoS Genetics

Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3

(2015) Christine Mieck et al.   eLife

Minus-End-Directed Kinesin-14 Motors Align Antiparallel Microtubules to Control Metaphase Spindle Length

(2014) Austin J. Hepperla et al.   DEVELOPMENTAL CELL

B56-PP2A regulates motor dynamics for mitotic chromosome alignment

(2014) P. Xu et al.   JOURNAL OF CELL SCIENCE

The dynamics of microtubule minus ends in the human mitotic spindle

(2014) Nicolas Lecland et al.   NATURE CELL BIOLOGY

Prime movers: the mechanochemistry of mitotic kinesins

(2014) Robert A. Cross et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kinesin-14 and kinesin-5 antagonistically regulate microtubule nucleation by γ-TuRC in yeast and human cells

(2014) Zachary T. Olmsted et al.   Nature Communications

Kinesin-14 Pkl1 targets γ-tubulin for release from the γ-tubulin ring complex (γ-TuRC)‬‬‬‬‬‬‬

(2013) Zachary T. Olmsted et al.   CELL CYCLE

KIFC1 Is Essential for Bipolar Spindle Formation and Genomic Stability in the Primary Human Fibroblast IMR-90 Cell

(2013) Namil Kim et al.   CELL STRUCTURE AND FUNCTION

Antagonistic Spindle Motors and MAPs Regulate Metaphase Spindle Length and Chromosome Segregation

(2013) Viktoriya Syrovatkina et al.   CURRENT BIOLOGY

The human kinesin-14 HSET tracks the tips of growing microtubules in vitro

(2013) Marcus Braun et al.   Cytoskeleton

Kar3Vik1 Mechanochemistry Is Inhibited by Mutation or Deletion of the C Terminus of the Vik1 Subunit

(2013) Monika Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Common mechanistic themes for the powerstroke of kinesin-14 motors

(2013) Miguel A. Gonzalez et al.   JOURNAL OF STRUCTURAL BIOLOGY

Meiosis-Specific Stable Binding of Augmin to Acentrosomal Spindle Poles Promotes Biased Microtubule Assembly in Oocytes

(2013) Nathalie Colombié et al.   PLoS Genetics

Mitotic motors and chromosome segregation: the mechanism of anaphase B: Figure 1

(2012) Ingrid Brust-Mascher et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

EBs Recognize a Nucleotide-Dependent Structural Cap at Growing Microtubule Ends

(2012) Sebastian P. Maurer et al.   CELL

Neck Rotation and Neck Mimic Docking in the Noncatalytic Kar3-associated Protein Vik1

(2012) Da Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ATPase Pathway That Drives the Kinesin-14 Kar3Vik1 Powerstroke

(2012) Chun Ju Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET

(2012) Julia Kleylein-Sohn et al.   JOURNAL OF CELL SCIENCE

Coupling of kinesin ATP turnover to translocation and microtubule regulation: one engine, many machines

(2012) Claire T. Friel et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

The kinesin-14 Klp2 is negatively regulated by the SIN for proper spindle elongation and telophase nuclear positioning

(2012) Sebastian Mana-Capelli et al.   MOLECULAR BIOLOGY OF THE CELL

Measuring collective transport by defined numbers of processive and nonprocessive kinesin motors

(2012) K. Furuta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acentrosomal spindle assembly and chromosome segregation during oocyte meiosis

(2012) Julien Dumont et al.   TRENDS IN CELL BIOLOGY

Two-state displacement by the kinesin-14 Ncd stalk

(2011) Mark A. Hallen et al.   BIOPHYSICAL CHEMISTRY

Protein complexes at the microtubule organizing center regulate bipolar spindle assembly

(2011) Adrianna S. Rodriguez et al.   CELL CYCLE

Distinct Kinesin-14 mitotic mechanisms in spindle bipolarity

(2011) Dimitre R. Simeonov et al.   CELL CYCLE

A Nonmotor Microtubule Binding Site in Kinesin-5 Is Required for Filament Crosslinking and Sliding

(2011) Joshua S. Weinger et al.   CURRENT BIOLOGY

Control of Mitotic Spindle Length

(2010) Gohta Goshima et al.   Annual Review of Cell and Developmental Biology

Patterns of kinesin evolution reveal a complex ancestral eukaryote with a multifunctional cytoskeleton

(2010) Bill Wickstead et al.   BMC EVOLUTIONARY BIOLOGY

Proper Organization of Microtubule Minus Ends Is Needed for Midzone Stability and Cytokinesis

(2010) Shang Cai et al.   CURRENT BIOLOGY

Plus-End-Tracking Proteins and Their Interactions at Microtubule Ends

(2010) Niels Galjart   CURRENT BIOLOGY

Microtubule tip-interacting proteins: a view from both ends

(2010) Kai Jiang et al.   CURRENT OPINION IN CELL BIOLOGY

Prometaphase spindle maintenance by an antagonistic motor-dependent force balance made robust by a disassembling lamin-B envelope

(2010) Gul Civelekoglu-Scholey et al.   JOURNAL OF CELL BIOLOGY

Microtubule organization by the antagonistic mitotic motors kinesin-5 and kinesin-14

(2010) Christian Hentrich et al.   JOURNAL OF CELL BIOLOGY

How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays

(2010) Linda Wordeman   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Microtubule motors in eukaryotic spindle assembly and maintenance

(2010) Jesse C. Gatlin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Walking, hopping, diffusing and braking modes of kinesin-5: Figure 1

(2009) Kuniyoshi Kaseda et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

An EB1-Binding Motif Acts as a Microtubule Tip Localization Signal

(2009) Srinivas Honnappa et al.   CELL

Mitotic Microtubule Crosslinkers: Insights from Mechanistic Studies

(2009) Erwin J.G. Peterman et al.   CURRENT BIOLOGY

A little CIN may cost a lot: revisiting aneuploidy and cancer

(2009) Namrata S Chandhok et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Interactions between Subunits in Heterodimeric Ncd Molecules

(2009) Elzbieta Kocik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinesin-5–dependent Poleward Flux and Spindle Length Control in Drosophila Embryo Mitosis

(2009) Ingrid Brust-Mascher et al.   MOLECULAR BIOLOGY OF THE CELL

The kinesin-14 Klp2 organizes microtubules into parallel bundles by an ATP-dependent sorting mechanism

(2009) Marcus Braun et al.   NATURE CELL BIOLOGY

The mitotic kinesin-14 Ncd drives directional microtubule–microtubule sliding

(2009) Gero Fink et al.   NATURE CELL BIOLOGY

Chromosome congression in the absence of kinetochore fibres

(2009) Shang Cai et al.   NATURE CELL BIOLOGY

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Orchestrating nuclear envelope disassembly and reassembly during mitosis

(2009) Stephan Güttinger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

EB1 Recognizes the Nucleotide State of Tubulin in the Microtubule Lattice

(2009) Marija Zanic et al.   PLoS One

A Tale of Too Many Centrosomes

(2008) Ceyda Acilan et al.   CELL

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL

Minus-End-Directed Motor Ncd Exhibits Processive Movement that Is Enhanced by Microtubule Bundling In Vitro

(2008) Ken'ya Furuta et al.   CURRENT BIOLOGY

Kinetochore–microtubule interactions: the means to the end

(2008) Tomoyuki U Tanaka et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

Diffusion and Directed Movement

(2008) Ken'ya Furuta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule cross-linking triggers the directional motility of kinesin-5

(2008) Lukas C. Kapitein et al.   JOURNAL OF CELL BIOLOGY

Ncd motor binding and transport in the spindle

(2008) M. A. Hallen et al.   JOURNAL OF CELL SCIENCE

Sister Kinetochore Recapture in Fission Yeast Occurs by Two Distinct Mechanisms, Both Requiring Dam1 and Klp2

(2008) Yannick Gachet et al.   MOLECULAR BIOLOGY OF THE CELL

Kinesin-14 Family Proteins HSET/XCTK2 Control Spindle Length by Cross-Linking and Sliding Microtubules

(2008) Shang Cai et al.   MOLECULAR BIOLOGY OF THE CELL

EB1 regulates microtubule dynamics and tubulin sheet closure in vitro

(2008) Benjamin Vitre et al.   NATURE CELL BIOLOGY

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS

Spatial and temporal coordination of mitosis by Ran GTPase

(2008) Paul R. Clarke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tracking the ends: a dynamic protein network controls the fate of microtubule tips

(2008) Anna Akhmanova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intracellular Transport and Kinesin Superfamily Proteins, KIFs: Structure, Function, and Dynamics

(2008) Nobutaka Hirokawa et al.   PHYSIOLOGICAL REVIEWS