Ubiquitination-Proteasome System (UPS) and Autophagy Two Main Protein Degradation Machineries in Response to Cell Stress

Chaperone-mediated autophagy sustains haematopoietic stem-cell function

(2021) Shuxian Dong et al.   NATURE

DUSP4 inhibits autophagic cell death in PTC by inhibiting JNK-BCL2-Beclin1 signaling

(2021) Huixiang He et al.   Biochemistry and Cell Biology

The Roles of the Ubiquitin–Proteasome System in the Endoplasmic Reticulum Stress Pathway

(2021) Junyan Qu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

How Is the Fidelity of Proteins Ensured in Terms of Both Quality and Quantity at the Endoplasmic Reticulum? Mechanistic Insights into E3 Ubiquitin Ligases

(2021) Ji An Kang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of MKRN1 as a second E3 ligase for Eag1 potassium channels reveals regulation via differential degradation

(2021) Ya-Ching Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XBP1- IGFBP3 Signaling Pathway Promotes NSCLC Invasion and Metastasis

(2021) Qingxi Luo et al.   Frontiers in Oncology

The Prognostic Value of PERK in Cancer and Its Relationship With Immune Cell Infiltration

(2021) Peng Wang et al.   Frontiers in Molecular Biosciences

Up-down regulation of HIF-1α in cancer progression

(2021) Mohsen Rashid et al.   GENE

Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation

(2021) Eleonora Turco et al.   Nature Communications

The significance of exosomes in the development and treatment of hepatocellular carcinoma

(2020) Xin Li et al.   Molecular Cancer

ID1 confers cancer cell chemoresistance through STAT3/ATF6-mediated induction of autophagy

(2020) Jiao Meng et al.   Cell Death & Disease

Dynamic post-translational modification profiling of Mycobacterium tuberculosis-infected primary macrophages

(2020) Jonathan M Budzik et al.   eLife

Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling

(2020) Neha Shrestha et al.   JOURNAL OF CLINICAL INVESTIGATION

De novo variants in SIAH1, encoding an E3 ubiquitin ligase, are associated with developmental delay, hypotonia and dysmorphic features

(2020) Julien Buratti et al.   JOURNAL OF MEDICAL GENETICS

Activating transcription factor 6 regulated cell growth, migration and inhibiteds cell apoptosis and autophagy via MAPK pathway in cervical cancer

(2020) Fang Liu et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation

(2020) Qin Xia et al.   ONCOGENE

The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting

(2020) Josephine Mathilde Elisabeth Tan et al.   Cell Reports

Impact of HDAC Inhibitors on Protein Quality Control Systems: Consequences for Precision Medicine in Malignant Disease

(2020) Linda Anna Michelle Kulka et al.   Frontiers in Cell and Developmental Biology

Releasing the Lockdown: An Emerging Role for the Ubiquitin-Proteasome System in the Breakdown of Transient Protein Inclusions

(2020) Yuval Reiss et al.   Biomolecules

Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly‐ubiquitylation

(2020) Christian Lips et al.   EMBO JOURNAL

Parkin-linked Parkinson’s disease: From clinical insights to pathogenic mechanisms and novel therapeutic approaches

(2020) Kobi Wasner et al.   NEUROSCIENCE RESEARCH

Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics

(2020) Tiejian Nie et al.   Autophagy

The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond

(2020) Nicola A. Scott et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Role of α-Synuclein Oligomers in Parkinson’s Disease

(2020) Xiao-yu Du et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson’s Disease Physiopathology

(2020) Cristine Alves da Costa et al.   Cells

Linking the Endoplasmic Reticulum to Parkinson’s Disease and Alpha-Synucleinopathy

(2019) Emanuela Colla   Frontiers in Neuroscience

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson’s disease

(2019) Saurav Brahmachari et al.   BRAIN

Atiprimod induce apoptosis in pituitary adenoma: Endoplasmic reticulum stress and autophagy pathways

(2019) Ajda Coker‐Gurkan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling

(2019) Claudia N. Spaan et al.   Cell Death & Disease

Octyl-itaconate inhibits osteoclastogenesis by suppressing Hrd1 and activating Nrf2 signaling

(2019) Xuewu Sun et al.   FASEB JOURNAL

Ubiquitin ligase RNF5 serves an important role in the development of human glioma

(2019) Yong Gao et al.   Oncology Letters

Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response

(2019) Yuning Lin et al.   BIOMEDICINE & PHARMACOTHERAPY

Post-translational modification of Parkin and its research progress in cancer

(2019) Dan Ding et al.   Cancer Communications

Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy

(2018) Jiwei Wang et al.   Autophagy

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy regulation and its dual role in blood cancers: A novel target for therapeutic development (Review)

(2018) Shenhe Jin et al.   ONCOLOGY REPORTS

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways

(2018) Jiwon Hwang et al.   TRENDS IN BIOCHEMICAL SCIENCES

U-box ubiquitin ligase PPIL2 suppresses breast cancer invasion and metastasis by altering cell morphology and promoting SNAI1 ubiquitination and degradation

(2018) Zhaojun Jia et al.   Cell Death & Disease

Induction of (Ubiquitin C ) UBC gene transcription is mediated by HSF1: role of proteotoxic and oxidative stress

(2018) Marzia Bianchi et al.   FEBS Open Bio

IRF3 Negatively Regulates Toll-Like Receptor-Mediated NF-κB Signaling by Targeting TRIF for Degradation in Teleost Fish

(2018) Xueyan Zhao et al.   Frontiers in Immunology

Migration inhibition of water stress proteins from Nostoc commune Vauch. via activation of autophagy in DLD-1 cells

(2018) Songjia Guo et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Protein Quality Control in the Endoplasmic Reticulum and Cancer

(2018) Hye Won Moon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation

(2017) Lei Ji et al.   GENES & DEVELOPMENT

Crosstalk of ER stress-mediated autophagy and ER-phagy: Involvement of UPR and the core autophagy machinery

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation

(2017) Amit Gupta et al.   MOLECULAR CELL

Polyglutamine tracts regulate beclin 1-dependent autophagy

(2017) Avraham Ashkenazi et al.   NATURE

Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway

(2017) He Huang et al.   Oncology Letters

TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1

(2017) Yusuke Hirata et al.   Cell Reports

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin‐1

(2016) Shouheng Jin et al.   EMBO JOURNAL

The ubiquitin-proteasome system and autophagy: Coordinated and independent activities

(2016) Victoria Cohen-Kaplan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Ubiquitin chain diversity at a glance

(2016) Masato Akutsu et al.   JOURNAL OF CELL SCIENCE

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Colorectal Carcinogenesis, Radiation Quality, and the Ubiquitin-Proteasome Pathway

(2016) Kamal Datta et al.   Journal of Cancer

RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy

(2015) Qi Luan et al.   Autophagy

ER stress: Autophagy induction, inhibition and selection

(2015) Harun-Or Rashid et al.   Autophagy

Disruption of polyubiquitin gene Ubc leads to attenuated resistance against arsenite-induced toxicity in mouse embryonic fibroblasts

(2015) Mi-Nam Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1 

(2015) H. Fujita et al.   EMBO JOURNAL

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

(2015) Jinghui Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

(2015) Junghyun Lim et al.   PLoS Genetics

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment

(2015) Sílvia Cufí et al.   Oncotarget

Gliotoxin Suppresses NF-κB Activation by Selectively Inhibiting Linear Ubiquitin Chain Assembly Complex (LUBAC)

(2014) Hiroki Sakamoto et al.   ACS Chemical Biology

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

(2014) Wen-Xing Ding et al.   Autophagy

Crosstalk between autophagy and proteasome protein degradation systems: possible implications for cancer therapy

(2014) Slawomir Wojcik   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Ubiquitination of Inositol-requiring Enzyme 1 (IRE1) by the E3 Ligase CHIP Mediates the IRE1/TRAF2/JNK Pathway

(2014) Xu Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hrd1-mediated BLIMP-1 ubiquitination promotes dendritic cell MHCII expression for CD4 T cell priming during inflammation

(2014) Heeyoung Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of the Death-Associated Protein Kinase 1 Expression and Autophagy via ATF6 Requires Apoptosis Signal-Regulating Kinase 1

(2014) P. Gade et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of mTOR pathway attenuates migration and invasion of gallbladder cancer via EMT inhibition

(2014) Huajie Zong et al.   MOLECULAR BIOLOGY REPORTS

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

(2014) Eric S. Fischer et al.   NATURE

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease

(2014) Sian E. Davies et al.   NEUROBIOLOGY OF DISEASE

Enhanced p62 expression through impaired proteasomal degradation is involved in caspase-1 activation in monosodium urate crystal-induced interleukin-1  expression

(2014) J.-Y. Choe et al.   RHEUMATOLOGY

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis

(2014) Taoling Zeng et al.   Cell Reports

A novel crosstalk between two major protein degradation systems

(2013) Xiao J Wang et al.   Autophagy

K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells

(2013) Juan F. Linares et al.   MOLECULAR CELL

Novel, Gel-free Proteomics Approach Identifies RNF5 and JAMP as Modulators of GPCR Stability

(2013) Sébastien J. Roy et al.   MOLECULAR ENDOCRINOLOGY

FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade

(2013) Shafi Kuchay et al.   NATURE CELL BIOLOGY

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

The anti-malarial chloroquine overcomes Primary resistance and restores sensitivity to Trastuzumab in HER2-positive breast cancer

(2013) Sílvia Cufí et al.   Scientific Reports

Ubiquitin at the crossroad of cell death and survival

(2013) Yu-Shan Chen et al.   Chinese Journal of Cancer

Depletion ofL-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes

(2012) Rósula García-Navas et al.   Autophagy

The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway

(2012) Y. Wang et al.   CANCER RESEARCH

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

(2012) Chia-Hsin Chan et al.   CELL

Ablation of gp78 in Liver Improves Hyperlipidemia and Insulin Resistance by Inhibiting SREBP to Decrease Lipid Biosynthesis

(2012) Tong-Fei Liu et al.   Cell Metabolism

Ring Finger Protein 149 Is an E3 Ubiquitin Ligase Active on Wild-type v-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF)

(2012) Seung-Woo Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XBP1mRNA Splicing Triggers an Autophagic Response in Endothelial Cells throughBECLIN-1Transcriptional Activation

(2012) Andriana Margariti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer

(2012) J. E. Grim et al.   MOLECULAR AND CELLULAR BIOLOGY

The E3-Ubiquitin Ligase TRIM50 Interacts with HDAC6 and p62, and Promotes the Sequestration and Clearance of Ubiquitinated Proteins into the Aggresome

(2012) Carmela Fusco et al.   PLoS One

BAG3 and friends: Co-chaperones in selective autophagy during aging and disease

(2011) Christian Behl   Autophagy

The dual role of autophagy in cancer

(2011) Eeva-Liisa Eskelinen   CURRENT OPINION IN PHARMACOLOGY

The E3 Ligase Smurf1 Regulates Wolfram Syndrome Protein Stability at the Endoplasmic Reticulum

(2011) Xing Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Characterization of Aggregating Proteins after the Inhibition of the Ubiquitin Proteasome System

(2011) Inga B. Wilde et al.   JOURNAL OF PROTEOME RESEARCH

mTOR Generates an Auto-Amplification Loop by Triggering the βTrCP- and CK1α-Dependent Degradation of DEPTOR

(2011) Shanshan Duan et al.   MOLECULAR CELL

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

(2011) L. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release

(2011) Hanna-Mari Tervo et al.   Retrovirology

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer’s disease amyloidosis and improves synaptic function

(2010) Bing Gong et al.   AGING CELL

Processing of autophagic protein LC3 by the 20S proteasome

(2010) Zhonghua Gao et al.   Autophagy

Quantification of oxidative stress in live mouse embryonic fibroblasts by monitoring the responses of polyubiquitin genes

(2010) Han-Wook Ryu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteasome inhibition: A new therapeutic strategy to cancer treatment

(2010) William Ka Kei Wu et al.   CANCER LETTERS

Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy

(2010) William K.K. Wu et al.   DRUG RESISTANCE UPDATES

Interaction between parkin and mutant glucocerebrosidase variants: a possible link between Parkinson disease and Gaucher disease

(2010) I. Ron et al.   HUMAN MOLECULAR GENETICS

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination of Autophagy and the Proteasome in Resolving Endoplasmic Reticulum Stress

(2010) X. Chen et al.   VETERINARY PATHOLOGY

Repression of protein translation and mTOR signaling by proteasome inhibitor in colon cancer cells

(2009) William Ka Kei Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib

(2009) M. Milani et al.   CANCER RESEARCH

Stressing the ubiquitin-proteasome system

(2009) N. P. Dantuma et al.   CARDIOVASCULAR RESEARCH

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

Differential regulation of CFTRΔF508 degradation by ubiquitin ligases gp78 and Hrd1

(2009) Petek Ballar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Quality Control Against Misfolded Proteins in the Cytosol: A Network for Cell Survival

(2009) H. Kubota   JOURNAL OF BIOCHEMISTRY

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress

(2009) You-Wei Zhang et al.   MOLECULAR CELL

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

(2009) T. Iwawaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Identification of amino acids within the second alpha helical domain of the human immunodeficiency virus type 1 Vpu that are critical for preventing CD4 cell surface expression

(2009) M. Sarah Hill et al.   VIROLOGY

Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells

(2008) William Ka Kei Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

How IRE1 Reacts to ER Stress

(2008) David Ron et al.   CELL

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

(2008) John C. Christianson et al.   NATURE CELL BIOLOGY

Akt and CHIP coregulate tau degradation through coordinated interactions

(2008) C. A. Dickey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA