Releasing the Lockdown: An Emerging Role for the Ubiquitin-Proteasome System in the Breakdown of Transient Protein Inclusions

Semisynthetic and Enzyme-Mediated Conjugate Preparations Illuminate the Ubiquitination-Dependent Aggregation of Tau Protein

(2020) Francesca Munari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Promiscuous Roles of Autophagy and Proteasome in Neurodegenerative Proteinopathies

(2020) Fiona Limanaqi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones

(2020) Despina Serlidaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions

(2020) Fabian den Brave et al.   Cell Reports

Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme

(2019) Rachel Cliffe et al.   Cell Reports

HSP101 Interacts with the Proteasome and Promotes the Clearance of Ubiquitylated Protein Aggregates

(2019) Fionn McLoughlin et al.   PLANT PHYSIOLOGY

Three J-proteins impact Hsp104-mediated variant-specific prion elimination: a new critical role for a low-complexity domain

(2019) Scott E. Berger et al.   CURRENT GENETICS

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Age‐related neurodegenerative diseases

(2019) Michael Duggan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Autophagy and Ubiquitin-Proteasome System Coordinate to Regulate the Protein Quality Control of Neurodegenerative Disease-Associated DCTN1

(2019) Nana Wang et al.   NEUROTOXICITY RESEARCH

Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis

(2019) Chi-ting Ho et al.   Nature Communications

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment

(2018) Qiang Guo et al.   CELL

Phosphorylation-Mediated Clearance of Amyloid-like Assemblies in Meiosis

(2018) Kayla Carpenter et al.   DEVELOPMENTAL CELL

Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation

(2018) Zhe Sha et al.   JOURNAL OF CELL BIOLOGY

Hsp70–Hsp110 chaperones deliver ubiquitin-dependent and -independent substrates to the 26S proteasome for proteolysis in yeast

(2018) Ganapathi Kandasamy et al.   JOURNAL OF CELL SCIENCE

Cellular Handling of Protein Aggregates by Disaggregation Machines

(2018) Axel Mogk et al.   MOLECULAR CELL

Substrate Insolubility Dictates Hsp104-Dependent Endoplasmic-Reticulum-Associated Degradation

(2018) G. Michael Preston et al.   MOLECULAR CELL

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

UBL domain of Usp14 and other proteins stimulates proteasome activities and protein degradation in cells

(2018) Hyoung Tae Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meddling with Fate: The Proteasomal Deubiquitinating Enzymes

(2017) Stefanie A.H. de Poot et al.   JOURNAL OF MOLECULAR BIOLOGY

Coordinated Hsp110 and Hsp104 Activities Power Protein Disaggregation in Saccharomyces cerevisiae

(2017) Jayasankar Mohanakrishnan Kaimal et al.   MOLECULAR AND CELLULAR BIOLOGY

In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome

(2017) Hikaru Tsuchiya et al.   MOLECULAR CELL

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

(2016) Roland Hjerpe et al.   CELL

Stefan Jentsch (1955–2016)—Maestro of the ubiquitin family

(2016) Thorsten Hoppe et al.   EMBO JOURNAL

Enhancing protein disaggregation restores proteasome activity in aged cells

(2016) Veronica Andersson et al.   Aging-US

Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition

(2015) S. B. Miller et al.   EMBO JOURNAL

Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

(2015) Xuechao Gao et al.   MOLECULAR CELL

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

(2015) Nadinath B. Nillegoda et al.   NATURE

Nonspecific yet decisive: Ubiquitination can affect the native-state dynamics of the modified protein

(2015) Yulian Gavrilov et al.   PROTEIN SCIENCE

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates

(2015) Daichi Morimoto et al.   Nature Communications

A new class of ubiquitin-Atg8 receptors involved in selective autophagy and polyQ protein clearance

(2014) Kefeng Lu et al.   Autophagy

Opposing roles of Ubp3-dependent deubiquitination regulate replicative life span and heat resistance

(2014) D. Oling et al.   EMBO JOURNAL

A Chaperone-Assisted Degradation Pathway Targets Kinetochore Proteins to Ensure Genome Stability

(2014) Franziska Kriegenburg et al.   PLoS Genetics

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

Ubiquitin conjugation triggers misfolded protein sequestration into quality control foci when Hsp70 chaperone levels are limiting

(2013) Ayala Shiber et al.   MOLECULAR BIOLOGY OF THE CELL

Proteasomes Activate Aggresome Disassembly and Clearance by Producing Unanchored Ubiquitin Chains

(2013) Rui Hao et al.   MOLECULAR CELL

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

(2013) Stéphanie Escusa-Toret et al.   NATURE CELL BIOLOGY

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

(2012) Liliana Malinovska et al.   MOLECULAR BIOLOGY OF THE CELL

The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

(2011) James Shorter   PLoS One

Yeast Deubiquitinase Ubp3 Interacts with the 26 S Proteasome to Facilitate Rad4 Degradation

(2010) Peng Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trimming of Ubiquitin Chains by Proteasome-associated Deubiquitinating Enzymes

(2010) Min Jae Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins

(2008) Marie W. Wooten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

Global Protein Stability Profiling in Mammalian Cells

(2008) H.-C. S. Yen et al.   SCIENCE