The Role of α-Synuclein Oligomers in Parkinson’s Disease

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

(2020) Chris McKinnon et al.   Acta Neuropathologica Communications

Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease

(2020) Min Guo et al.   BRAIN

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

(2020) Plamena R. Angelova et al.   CELL DEATH AND DIFFERENTIATION

Protein transmission in neurodegenerative disease

(2020) Chao Peng et al.   Nature Reviews Neurology

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

(2020) Ryan Limbocker et al.   Communications Biology

Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity

(2019) Malcolm J. Daniels et al.   Scientific Reports

Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes

(2019) Juan F. Reyes et al.   ACTA NEUROPATHOLOGICA

Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration

(2019) Valentina Durante et al.   BRAIN

α-Synuclein induced mitochondrial dysfunction via cytochrome c oxidase subunit 2 in SH-SY5Y cells

(2019) Lin Danyu et al.   EXPERIMENTAL CELL RESEARCH

Progress of immunotherapy of anti-α-synuclein in Parkinson’s disease

(2019) Zhipeng Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Hsp110 mitigates α-synuclein pathology in vivo

(2019) Yumiko V. Taguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8–16-mer Oligomer Species

(2019) Martin Kiechle et al.   Cell Reports

α-Synuclein Oligomers Induce a Unique Toxic Tau Strain

(2018) Diana L. Castillo-Carranza et al.   BIOLOGICAL PSYCHIATRY

Extracellular α-Synuclein Disrupts Membrane Nanostructure and Promotes S-Nitrosylation-Induced Neuronal Cell Death

(2018) Roshan Kumar et al.   BIOMACROMOLECULES

Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson’s Disease Etiopathology

(2018) Anna Wilkaniec et al.   MOLECULAR NEUROBIOLOGY

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

(2018) Julia E. Gerson et al.   Molecular Neurodegeneration

Subcellular localization of alpha-synuclein aggregates and their interaction with membranes

(2018) Emanuela Colla et al.   Neural Regeneration Research

Dual neuroprotective role of Hsp2 against α-Synuclein aggregates

(2018) M.A.H.M. Jamal et al.   PARKINSONISM & RELATED DISORDERS

α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies

(2018) Iryna Prots et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of Synucleinopathy

(2018) Martin Kallab et al.   Frontiers in Neuroscience

Novel DNA Aptamers for Parkinson’s Disease Treatment Inhibit α-Synuclein Aggregation and Facilitate its Degradation

(2018) Yuan Zheng et al.   Molecular Therapy-Nucleic Acids

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis

(2018) Craig D. Hughes et al.   ACTA NEUROPATHOLOGICA

Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons

(2018) Cecilia Chavarría et al.   BIOCHEMICAL JOURNAL

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

(2018) Changyoun Kim et al.   Molecular Neurodegeneration

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

(2018) Binsen Li et al.   Nature Communications

Morphological Evaluation of Meta-stable Oligomers of α-Synuclein with Small-Angle Neutron Scattering

(2018) Ghibom Bhak et al.   Scientific Reports

Quantifying Co-Oligomer Formation by α-Synuclein

(2018) Marija Iljina et al.   ACS Nano

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

(2017) Gabriel Gustafsson et al.   Journal of Neuroinflammation

Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage

(2017) Veronica Lindström et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC

(2017) Kazunori Sano et al.   MOLECULAR NEUROBIOLOGY

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

(2017) Diana G Ferreira et al.   NATURE NEUROSCIENCE

Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy

(2017) Omar El-Agnaf et al.   NEUROBIOLOGY OF DISEASE

A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein

(2017) Franziska Richter et al.   Neurotherapeutics

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

(2017) Michele Perni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

(2017) Giuliana Fusco et al.   SCIENCE

EGCG-mediated Protection of the Membrane Disruption and Cytotoxicity Caused by the ‘Active Oligomer’ of α-Synuclein

(2017) Jee Eun Yang et al.   Scientific Reports

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

(2016) Emma Deas et al.   ANTIOXIDANTS & REDOX SIGNALING

Baicalein inhibits α-synuclein oligomer formation and prevents progression of α-synuclein accumulation in a rotenone mouse model of Parkinson's disease

(2016) Qi Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors

(2016) Gabriel Gustafsson et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson’s disease

(2016) T. Q. Melo et al.   EXPERIMENTAL BRAIN RESEARCH

A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses

(2016) Jun Zha et al.   Scientific Reports

Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes

(2015) Corinna Bliederhaeuser et al.   ACTA NEUROPATHOLOGICA

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death

(2015) A-L Mahul-Mellier et al.   CELL DEATH AND DIFFERENTIATION

Definition of a Molecular Pathway Mediating  -Synuclein Neurotoxicity

(2015) J. Burre et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology

(2015) Nishant N. Vaikath et al.   NEUROBIOLOGY OF DISEASE

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation

(2015) Dhiman Ghosh et al.   Scientific Reports

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Number and Brightness analysis of alpha-synuclein oligomerization and the associated mitochondrial morphology alterations in live cells

(2014) N. Plotegher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

(2014) Edward Rockenstein et al.   BRAIN

α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

(2014) Lina Wang et al.   CURRENT BIOLOGY

Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction

(2014) Eric S. Luth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation

(2014) Nikolai Lorenzen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease

(2014) Marcos J. Guerrero-Muñoz et al.   NEUROBIOLOGY OF DISEASE

Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

(2014) Tiago Fleming Outeiro et al.   PLoS One

Intramuscular injection of  -synuclein induces CNS  -synuclein pathology and a rapid-onset motor phenotype in transgenic mice

(2014) A. N. Sacino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

(2013) Nolwen L. Rey et al.   ACTA NEUROPATHOLOGICA

Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice

(2013) Ling Wang et al.   EXPERIMENTAL NEUROLOGY

The N-terminus of α-synuclein is essential for both monomeric and oligomeric interactions with membranes

(2013) Nikolai Lorenzen et al.   FEBS LETTERS

α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay

(2013) Iryna Prots et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large  -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

(2013) B.-K. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure

(2012) María Soledad Celej et al.   BIOCHEMICAL JOURNAL

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

(2012) M. J. Diogenes et al.   JOURNAL OF NEUROSCIENCE

Accumulation of Toxic  -Synuclein Oligomer within Endoplasmic Reticulum Occurs in  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic Reticulum Stress Is Important for the Manifestations of  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Differential Activation of the ER Stress Factor XBP1 by Oligomeric Assemblies

(2012) Diana L. Castillo-Carranza et al.   NEUROCHEMICAL RESEARCH

Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of  -Synuclein

(2011) D. Ebrahimi-Fakhari et al.   JOURNAL OF NEUROSCIENCE

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

(2011) Sharmistha Sinha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ER stress response plays an important role in aggregation of α-synuclein

(2011) Peizhou Jiang et al.   Molecular Neurodegeneration

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Low-resolution structure of a vesicle disrupting  -synuclein oligomer that accumulates during fibrillation

(2011) L. Giehm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preparation and Characterization of Neurotoxic Tau Oligomers

(2010) Cristian A. Lasagna-Reeves et al.   BIOCHEMISTRY

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

(2010) Karin M. Danzer et al.   FASEB JOURNAL

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Detecting Morphologically Distinct Oligomeric Forms of α-Synuclein

(2009) Sharareh Emadi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Seeding induced by α-synuclein oligomers provides evidence for spreading of α-synuclein pathology

(2009) Karin M. Danzer et al.   JOURNAL OF NEUROCHEMISTRY

Brain-Permeable Small-Molecule Inhibitors of Hsp90 Prevent  -Synuclein Oligomer Formation and Rescue  -Synuclein-Induced Toxicity

(2009) P. Putcha et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structural Properties of Pore-Forming Oligomers of α-Synuclein

(2009) Hai-Young Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CHIP Targets Toxic α-Synuclein Oligomers for Degradation

(2008) Julie E. Tetzlaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome

(2008) Evangelia Emmanouilidou et al.   NEUROBIOLOGY OF AGING