Who with whom: functional coordination of E2 enzymes by RING E3 ligases during poly‐ubiquitylation

Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation

(2020) Emma Branigan et al.   Nature Communications

Enzymatic Logic of Ubiquitin Chain Assembly

(2019) Kirandeep K. Deol et al.   Frontiers in Physiology

Two functionally distinct E2/E3 pairs coordinate sequential ubiquitination of a common substrate inCaenorhabditis elegansdevelopment

(2017) Katja K. Dove et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms

(2017) Mikaela D. Stewart et al.   PROTEIN SCIENCE

Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD

(2016) Ryan D. Baldridge et al.   CELL

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

(2016) Daniel C. Scott et al.   CELL

E2 enzymes: more than just middle men

(2016) Mikaela D Stewart et al.   CELL RESEARCH

Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms

(2016) Katja K Dove et al.   EMBO REPORTS

The CUE Domain of Cue1 Aligns Growing Ubiquitin Chains with Ubc7 for Rapid Elongation

(2016) Maximilian von Delbrück et al.   MOLECULAR CELL

Sequential Poly-ubiquitylation by Specialized Conjugating Enzymes Expands the Versatility of a Quality Control Ubiquitin Ligase

(2016) Annika Weber et al.   MOLECULAR CELL

Crystal Structure of a Ube2S-Ubiquitin Conjugate

(2016) Sonja Lorenz et al.   PLoS One

Atomic structure of the APC/C and its mechanism of protein ubiquitination

(2015) Leifu Chang et al.   NATURE

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains

(2015) Emma Branigan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases

(2015) Itamar Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

(2015) Nicholas G. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Version 4.0 of PaxDb: Protein abundance data, integrated across model organisms, tissues, and cell-lines

(2015) Mingcong Wang et al.   PROTEOMICS

Specificity of the anaphase-promoting complex: A single-molecule study

(2015) Y. Lu et al.   SCIENCE

The demographics of the ubiquitin system

(2015) Michael J. Clague et al.   TRENDS IN CELL BIOLOGY

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains

(2015) Emma Branigan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8

(2014) Daniel C. Scott et al.   CELL

Differential Ubiquitin Binding by the Acidic Loops of Ube2g1 and Ube2r1 Enzymes Distinguishes Their Lys-48-ubiquitylation Activities

(2014) Yun-Seok Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

Ubiquitin Chain Elongation Requires E3-Dependent Tracking of the Emerging Conjugate

(2014) Aileen Kelly et al.   MOLECULAR CELL

Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly

(2014) Nicholas G. Brown et al.   MOLECULAR CELL

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

(2013) Meredith B. Metzger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins

(2013) Nathan W. Pierce et al.   CELL

Ubiquitin Binding by a CUE Domain Regulates Ubiquitin Chain Formation by ERAD E3 Ligases

(2013) Katrin Bagola et al.   MOLECULAR CELL

A Structurally Unique E2-Binding Domain Activates Ubiquitination by the ERAD E2, Ubc7p, through Multiple Mechanisms

(2013) Meredith B. Metzger et al.   MOLECULAR CELL

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane

(2013) Martin Mehnert et al.   NATURE CELL BIOLOGY

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism

(2012) Ethan D. Emberley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases

(2012) Jonathan N. Pruneda et al.   MOLECULAR CELL

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

(2012) Anna Plechanovová et al.   NATURE

BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate

(2011) Jonathan N. Pruneda et al.   BIOCHEMISTRY

The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2

(2011) Katherine E. Wickliffe et al.   CELL

Essential Role for Ubiquitin-Ubiquitin-Conjugating Enzyme Interaction in Ubiquitin Discharge from Cdc34 to Substrate

(2011) Anjanabha Saha et al.   MOLECULAR CELL

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

(2011) Dawn M. Wenzel et al.   NATURE

Priming and Extending: A UbcH5/Cdc34 E2 Handoff Mechanism for Polyubiquitination on a SCF Substrate

(2010) Kenneth Wu et al.   MOLECULAR CELL

UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex

(2010) T. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid E2-E3 Assembly and Disassembly Enable Processive Ubiquitylation of Cullin-RING Ubiquitin Ligase Substrates

(2009) Gary Kleiger et al.   CELL

Mechanistic analysis of PCNA poly-ubiquitylation by the ubiquitin protein ligases Rad18 and Rad5

(2009) Joanne L Parker et al.   EMBO JOURNAL

Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates

(2009) Xiaoli Wang et al.   JOURNAL OF CELL BIOLOGY

A Ubc7p-binding domain in Cue1p activates ER-associated protein degradation

(2009) Z. Kostova et al.   JOURNAL OF CELL SCIENCE

Detection of sequential polyubiquitylation on a millisecond timescale

(2009) Nathan W. Pierce et al.   NATURE

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit

(2009) Mathew J. Garnett et al.   NATURE CELL BIOLOGY

E2 interaction and dimerization in the crystal structure of TRAF6

(2009) Qian Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of a physiological E2 module for the human anaphase-promoting complex

(2009) A. Williamson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex

(2008) Lingyan Jin et al.   CELL

The Unique N Terminus of the UbcH10 E2 Enzyme Controls the Threshold for APC Activation and Enhances Checkpoint Regulation of the APC

(2008) Matthew K. Summers et al.   MOLECULAR CELL

Mechanism and Consequences for Paralog-Specific Sumoylation of Ubiquitin-Specific Protease 25

(2008) Erik Meulmeester et al.   MOLECULAR CELL

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL

Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail

(2008) K. Yamoah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA