Post-translational modification of Parkin and its research progress in cancer

Type 2 diabetes‐induced hyposalivation of the submandibular gland through PINK1/Parkin‐mediated mitophagy

(2019) Ruo‐Lan Xiang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Parkin in Parkinson’s Disease and Cancer: a Double-Edged Sword

(2018) Khushnuma Wahabi et al.   MOLECULAR NEUROBIOLOGY

HMG-box transcription factor 1: a positive regulator of the G1/S transition through the Cyclin-CDK-CDKI molecular network in nasopharyngeal carcinoma

(2018) Shiwei He et al.   Cell Death & Disease

Critical role of FOXO3a in carcinogenesis

(2018) Ying Liu et al.   Molecular Cancer

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation

(2017) Amit Gupta et al.   MOLECULAR CELL

Phosphorylation and acetylation modifications of FOXO3a: Independently or synergistically?

(2017) Xianwang Wang et al.   Oncology Letters

Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression

(2017) Juan Liu et al.   Nature Communications

SUMO-regulated mitochondrial function in Parkinson's disease

(2016) Ana Cristina Guerra de Souza et al.   JOURNAL OF NEUROCHEMISTRY

Multiple-level validation identifies PARK2 in the development of lung cancer and chronic obstructive pulmonary disease

(2016) SeungBaek Lee et al.   Oncotarget

Visualizing K48 Ubiquitination during Presynaptic Formation By Ubiquitination-Induced Fluorescence Complementation (UiFC)

(2016) Maria J. Pinto et al.   Frontiers in Molecular Neuroscience

Factors in Association Between Parkinson Disease and Risk of Cancer in Taiwan

(2016) D. Michal Freedman et al.   JAMA Oncology

Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuroprotection

(2015) Liting Hang et al.   Annals of the New York Academy of Sciences

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

(2015) A. Kazlauskaite et al.   EMBO REPORTS

Parkin structure and function

(2015) Marjan Seirafi et al.   FEBS Journal

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1

(2015) Seung Baek Lee et al.   MOLECULAR CELL

Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy

(2014) Yongchao Zhao et al.   ANTIOXIDANTS & REDOX SIGNALING

Self and Nonself: How Autophagy Targets Mitochondria and Bacteria

(2014) Felix Randow et al.   Cell Host & Microbe

New insights into ubiquitin E3 ligase mechanism

(2014) Christopher E Berndsen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1

(2014) Richard G. Carroll et al.   Cell Reports

PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila

(2014) Kahori Shiba-Fukushima et al.   PLoS Genetics

Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation

(2013) Xiaodong Sun et al.   CELL CYCLE

Cigarette smoking and inflammation revisited

(2013) Oren Rom et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

FoxO3a is activated and executes neuron death via Bim in response to β-amyloid

(2013) P Sanphui et al.   Cell Death & Disease

S-nitrosylation regulates mitochondrial quality control via activation of parkin

(2013) Kentaro Ozawa et al.   Scientific Reports

Parkin Pathway Activation Mitigates Glioma Cell Proliferation and Predicts Patient Survival

(2012) C. W. S. Yeo et al.   CANCER RESEARCH

Regulation of parkin and PINK1 by neddylation

(2012) Y. S. Choo et al.   HUMAN MOLECULAR GENETICS

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

Neddylation positively regulates the ubiquitin E3 ligase activity of parkin

(2012) Ji Won Um et al.   JOURNAL OF NEUROSCIENCE RESEARCH

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes

(2011) Youngil Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mutant ataxin-3 promotes the autophagic degradation of parkin

(2011) Thomas M. Durcan et al.   Autophagy

Regulation of FoxO transcription factors by acetylation and protein–protein interactions

(2011) Hiroaki Daitoku et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines

(2011) Mitsutoshi Kadowaki et al.   INTERNATIONAL JOURNAL OF CANCER

Ataxin-3 Deubiquitination Is Coupled to Parkin Ubiquitination via E2 Ubiquitin-conjugating Enzyme

(2011) Thomas M. Durcan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

(2011) Fanjun Meng et al.   Molecular Neurodegeneration

Regulation of cell migration by dynamic microtubules

(2011) Irina Kaverina et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

GABARAPL1 (GEC1) associates with autophagic vesicles

(2010) Fatima Zahra Chakrama et al.   Autophagy

The Machado–Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability

(2010) Thomas M. Durcan et al.   HUMAN MOLECULAR GENETICS

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Parkin Enhances the Expression of Cyclin-dependent Kinase 6 and Negatively Regulates the Proliferation of Breast Cancer Cells

(2010) Shiam-Peng Tay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ubiquitin-proteasome pathway and synaptic plasticity

(2010) A. N. Hegde   LEARNING & MEMORY

Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity

(2009) Vanja Nagy et al.   BIOLOGICAL CHEMISTRY

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF- B signaling

(2009) D. Sha et al.   HUMAN MOLECULAR GENETICS

Attenuation of proteolysis-mediated cyclin E regulation by alternatively splicedParkinin human colorectal cancers

(2009) Kyoko Ikeuchi et al.   INTERNATIONAL JOURNAL OF CANCER

Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin

(2009) Ventzislava A. Hristova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin regulates paclitaxel sensitivity in breast cancer via a microtubule-dependent mechanism

(2009) Hongxia Wang et al.   JOURNAL OF PATHOLOGY

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

(2009) Selvaraju Veeriah et al.   NATURE GENETICS

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

(2008) Yongsung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The PINK1/Parkin pathway regulates mitochondrial morphology

(2008) A. C. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Term Interleukin-6 Levels and Subsequent Risk of Coronary Heart Disease: Two New Prospective Studies and a Systematic Review

(2008) John Danesh et al.   PLOS MEDICINE