Dissecting the Functional Role of the TRIM8 Protein on Cancer Pathogenesis

Targeting TRIM Proteins: A quest towards drugging an emerging protein class

(2021) Francesca D’Amico et al.   CHEMBIOCHEM

TRIM Proteins in Inflammation: from Expression to Emerging Regulatory Mechanisms

(2021) Luting Yang et al.   INFLAMMATION

Emerging Roles of TRIM8 in Health and Disease

(2021) Flaviana Marzano et al.   Cells

TRIM Proteins in Colorectal Cancer: TRIM8 as a Promising Therapeutic Target in Chemo Resistance

(2021) Flaviana Marzano et al.   Biomedicines

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability

(2020) Santina Venuto et al.   CANCER LETTERS

TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses

(2020) Martina Di Rienzo et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of TRIM8 restrains ischaemia-reperfusion-mediated cerebral injury by regulation of NF-κB activation associated inflammation and apoptosis

(2020) Xue Bai et al.   EXPERIMENTAL CELL RESEARCH

Mechanical regulation of glycolysis via cytoskeleton architecture

(2020) Jin Suk Park et al.   NATURE

The Tripartite Nexus: Autophagy, Cancer, and Tripartite Motif-Containing Protein Family Members

(2020) Michael A. Mandell et al.   Frontiers in Pharmacology

Discovery of linear ubiquitination, a crucial regulator for immune signaling and cell death

(2020) Kazuhiro Iwai   FEBS Journal

Suppression of TRIM8 by microRNA-182-5p restricts tumor necrosis factor-α-induced proliferation and migration of airway smooth muscle cells through inactivation of NF-Κb

(2020) Xiaomin Dang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Rise of TRIM8: A Molecule of Duality

(2020) Utsa Bhaduri et al.   Molecular Therapy-Nucleic Acids

The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders

(2020) Jacopo Di Gregorio et al.   Frontiers in Cell and Developmental Biology

TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

(2019) Xiancai Ma et al.   eLife

E3 Ubiquitin Ligase TRIM Proteins, Cell Cycle and Mitosis

(2019) Venuto et al.   Cells

The role of TRIM family proteins in the regulation of cancer stem cell self-renewal: Concise review

(2019) Anna Maria Jaworska et al.   STEM CELLS

TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells

(2019) Ghizlane Maarifi et al.   Science Advances

TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background

(2019) Mariano Francesco Caratozzolo et al.   Frontiers in Oncology

TRIM8 regulated autophagy modulates the level of cleaved Caspase-3 subunit to inhibit genotoxic stress induced cell death

(2018) Milton Roy et al.   CELLULAR SIGNALLING

Conserved structural and functional aspects of the tripartite motif gene family point towards therapeutic applications in multiple diseases

(2018) Liubov V. Gushchina et al.   PHARMACOLOGY & THERAPEUTICS

The molecular basis of JAK/STAT inhibition by SOCS1

(2018) Nicholas P. D. Liau et al.   Nature Communications

Autophagy processes are dependent on EGF receptor signaling

(2018) Vincenzo De Iuliis et al.   Oncotarget

TRIM8-driven transcriptomic profile of neural stem cells identified glioma-related nodal genes and pathways

(2018) Santina Venuto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

TRIM proteins and diseases

(2017) Masashi Watanabe et al.   JOURNAL OF BIOCHEMISTRY

TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF–TBK1 Interaction

(2017) Wen Ye et al.   JOURNAL OF IMMUNOLOGY

TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours

(2017) Francesca Mastropasqua et al.   Molecular Cancer

TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3

(2017) Changming Zhang et al.   Molecular Oncology

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

(2017) Shigetsugu Hatakeyama   TRENDS IN BIOCHEMICAL SCIENCES

Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment

(2017) Pedro M. Aponte et al.   Stem Cells International

Role of Linear Ubiquitination in Health and Disease

(2016) Patricia Brazee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tripartite Motif 8 (TRIM8) Positively Regulates Pro-inflammatory Responses in Pseudomonas aeruginosa-Induced Keratitis Through Promoting K63-Linked Polyubiquitination of TAK1 Protein

(2016) Litao Guo et al.   INFLAMMATION

TRIM28 multi-domain protein regulates cancer stem cell population in breast tumor development

(2016) Patrycja Czerwińska et al.   Oncotarget

Autophagy and p53

(2016) Eileen White   Cold Spring Harbor Perspectives in Medicine

TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival

(2015) Lucia Micale et al.   BMC CANCER

The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination

(2015) Lynn Elton et al.   IMMUNOLOGICAL REVIEWS

Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung

(2015) Hyo Sup Shim et al.   Journal of Thoracic Oncology

TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma

(2015) Mariano Francesco Caratozzolo et al.   Oncotarget

Structural insights into the TRIM family of ubiquitin E3 ligases

(2014) Yang Li et al.   CELL RESEARCH

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

TRIM8 modulates p53 activity to dictate cell cycle arrest

(2012) Mariano Francesco Caratozzolo et al.   CELL CYCLE

TRIM Protein-Mediated Regulation of Inflammatory and Innate Immune Signaling and Its Association with Antiretroviral Activity

(2012) P. D. Uchil et al.   JOURNAL OF VIROLOGY

TRIM16 Acts as an E3 Ubiquitin Ligase and Can Heterodimerize with Other TRIM Family Members

(2012) Jessica L. Bell et al.   PLoS One

Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

(2012) Ricardo Rajsbaum et al.   PLoS Pathogens

TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription

(2011) T. Sato et al.   JOURNAL OF CELL SCIENCE

Tripartite motif 8 (TRIM8) modulates TNF - and IL-1 -triggered NF- B activation by targeting TAK1 for K63-linked polyubiquitination

(2011) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes

(2011) Kyudong Han et al.   PLoS Genetics

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

Tripartite-motif proteins and innate immune regulation

(2010) Finlay W McNab et al.   CURRENT OPINION IN IMMUNOLOGY

The TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural Progenitors

(2009) Jens C. Schwamborn et al.   CELL

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties

(2008) Marco Sardiello et al.   BMC EVOLUTIONARY BIOLOGY

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

TRIM E3 Ligases Interfere with Early and Late Stages of the Retroviral Life Cycle

(2008) Pradeep D. Uchil et al.   PLoS Pathogens