TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3

Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport

(2016) Subhas Mukherjee et al.   CANCER RESEARCH

TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival

(2015) Lucia Micale et al.   BMC CANCER

TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma

(2015) Mariano Francesco Caratozzolo et al.   Oncotarget

Human Brat Ortholog TRIM3 Is a Tumor Suppressor That Regulates Asymmetric Cell Division in Glioblastoma

(2014) G. Chen et al.   CANCER RESEARCH

TLR9 Is Critical for Glioma Stem Cell Maintenance and Targeting

(2014) A. Herrmann et al.   CANCER RESEARCH

Low PIAS3 Expression in Malignant Mesothelioma Is Associated with Increased STAT3 Activation and Poor Patient Survival

(2014) S. Dabir et al.   CLINICAL CANCER RESEARCH

MicroRNA-18a modulates STAT3 activity through negative regulation of PIAS3 during gastric adenocarcinogenesis

(2013) W Wu et al.   BRITISH JOURNAL OF CANCER

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

Loss of Androgen Receptor Expression Promotes a Stem-like Cell Phenotype in Prostate Cancer through STAT3 Signaling

(2013) A. Schroeder et al.   CANCER RESEARCH

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

Nucleo-Cytoplasmic Trafficking of TRIM8, a Novel Oncogene, Is Involved in Positive Regulation of TNF Induced NF-κB Pathway

(2012) Dhanendra Tomar et al.   PLoS One

TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells

(2011) Fumihiko Okumura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3

(2011) Olga A. Guryanova et al.   CANCER CELL

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Tripartite motif 8 (TRIM8) modulates TNF - and IL-1 -triggered NF- B activation by targeting TAK1 for K63-linked polyubiquitination

(2011) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

(2010) F. Okumura et al.   JOURNAL OF CELL SCIENCE

Cancer stem cells: Invitation to a second round

(2010) Peter Dirks   NATURE

Identification of a New Series of STAT3 Inhibitors by Virtual Screening

(2010) Kenji Matsuno et al.   ACS Medicinal Chemistry Letters

Proteomic Changes Resulting from Gene Copy Number Variations in Cancer Cells

(2010) Tamar Geiger et al.   PLoS Genetics

TGF-β Increases Glioma-Initiating Cell Self-Renewal through the Induction of LIF in Human Glioblastoma

(2009) Silvia Peñuelas et al.   CANCER CELL

Stat3 activation is required for the growth of U87 cell-derived tumours in mice

(2009) Atreyi Dasgupta et al.   EUROPEAN JOURNAL OF CANCER

A MT1-MMP/NF-κB signaling axis as a checkpoint controller of COX-2 expression in CD133(+) U87 glioblastoma cells

(2009) Borhane Annabi et al.   Journal of Neuroinflammation

The Association and Nuclear Translocation of the PIAS3-STAT3 Complex Is Ligand and Time Dependent

(2009) S. Dabir et al.   MOLECULAR CANCER RESEARCH

Biology of glioma cancer stem cells

(2009) Deric M. Park et al.   MOLECULES AND CELLS

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

The Increasing Complexity of the Cancer Stem Cell Paradigm

(2009) J. M. Rosen et al.   SCIENCE

Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth

(2009) Hui Wang et al.   STEM CELLS

Loss of Protein Inhibitors of Activated STAT-3 Expression in Glioblastoma Multiforme Tumors: Implications for STAT-3 Activation and Gene Expression

(2008) E. C. Brantley et al.   CLINICAL CANCER RESEARCH

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE