Emerging Roles of TRIM8 in Health and Disease

TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability

(2020) Santina Venuto et al.   CANCER LETTERS

Inhibition of TRIM8 restrains ischaemia-reperfusion-mediated cerebral injury by regulation of NF-κB activation associated inflammation and apoptosis

(2020) Xue Bai et al.   EXPERIMENTAL CELL RESEARCH

TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

(2020) Dan Liu et al.   Cell Metabolism

Association of a de novo nonsense mutation of the TRIM8 gene with childhood-onset focal segmental glomerulosclerosis

(2020) Mikako Warren et al.   PEDIATRIC NEPHROLOGY

Discovery of linear ubiquitination, a crucial regulator for immune signaling and cell death

(2020) Kazuhiro Iwai   FEBS Journal

Suppression of TRIM8 by microRNA-182-5p restricts tumor necrosis factor-α-induced proliferation and migration of airway smooth muscle cells through inactivation of NF-Κb

(2020) Xiaomin Dang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MicroRNA-665-3p attenuates oxygen-glucose deprivation-evoked microglial cell apoptosis and inflammatory response by inhibiting NF-κB signaling via targeting TRIM8

(2020) Xiajing Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Focal segmental glomerulosclerosis and mild intellectual disability in a patient with a novel de novo truncating TRIM8 mutation

(2020) Martin A. McClatchey et al.   European Journal of Medical Genetics

Down-regulation of long noncoding RNA LINC00472 alleviates sepsis-induced acute hepatic injury by regulating miR-373-3p/TRIM8 axis

(2020) Lei Li et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Targeting Chemoresistant Tumors: Could TRIM Proteins-p53 Axis Be a Possible Answer?

(2019) Valletti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silencing of Long Noncoding RNA Nespas Aggravates Microglial Cell Death and Neuroinflammation in Ischemic Stroke

(2019) Yiming Deng et al.   STROKE

TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells

(2019) Ghizlane Maarifi et al.   Science Advances

TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background

(2019) Mariano Francesco Caratozzolo et al.   Frontiers in Oncology

Downregulation of TRIM8 protects neurons from oxygen–glucose deprivation/re-oxygenation-induced injury through reinforcement of the AMPK/Nrf2/ARE antioxidant signaling pathway

(2019) Wei Zhao et al.   BRAIN RESEARCH

TRIM8 regulated autophagy modulates the level of cleaved Caspase-3 subunit to inhibit genotoxic stress induced cell death

(2018) Milton Roy et al.   CELLULAR SIGNALLING

Further delineation of the clinical spectrum of de novo TRIM8 truncating mutations

(2018) Mirna Assoum et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Blocking of tripartite motif 8 protects against lipopolysaccharide (LPS)-induced acute lung injury by regulating AMPKα activity

(2018) Li Xiaoli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRIM8-driven transcriptomic profile of neural stem cells identified glioma-related nodal genes and pathways

(2018) Santina Venuto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis

(2017) Feng-Juan Yan et al.   HEPATOLOGY

TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF–TBK1 Interaction

(2017) Wen Ye et al.   JOURNAL OF IMMUNOLOGY

TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours

(2017) Francesca Mastropasqua et al.   Molecular Cancer

miR-182 promotes tumor growth and increases chemoresistance of human anaplastic thyroid cancer by targeting tripartite motif 8

(2017) Yao Liu et al.   OncoTargets and Therapy

TRIM8: Making the Right Decision between the Oncogene and Tumour Suppressor Role

(2017) Mariano Caratozzolo et al.   Genes

Role of Linear Ubiquitination in Health and Disease

(2016) Patricia Brazee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

De NovoTruncating Mutation ofTRIM8Causes Early-Onset Epileptic Encephalopathy

(2016) Yasunari Sakai et al.   ANNALS OF HUMAN GENETICS

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Fish TRIM8 exerts antiviral roles through regulation of the proinflammatory factors and interferon signaling

(2016) Youhua Huang et al.   FISH & SHELLFISH IMMUNOLOGY

Tripartite Motif 8 Contributes to Pathological Cardiac Hypertrophy Through Enhancing Transforming Growth Factor β–Activated Kinase 1–Dependent Signaling PathwaysNovelty and Significance

(2016) Lijuan Chen et al.   HYPERTENSION

Tripartite Motif 8 (TRIM8) Positively Regulates Pro-inflammatory Responses in Pseudomonas aeruginosa-Induced Keratitis Through Promoting K63-Linked Polyubiquitination of TAK1 Protein

(2016) Litao Guo et al.   INFLAMMATION

Nuclear translocation of annexin 1 following oxygen-glucose deprivation–reperfusion induces apoptosis by regulating Bid expression via p53 binding

(2016) Xing Li et al.   Cell Death & Disease

TRIM8 regulates the chemoresistance of colorectal cancer in a p53-dependent manner

(2016) Mingli Ni et al.   Oncology Letters

TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival

(2015) Lucia Micale et al.   BMC CANCER

XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NFκB activation

(2015) Fang Lin et al.   HUMAN MOLECULAR GENETICS

The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination

(2015) Lynn Elton et al.   IMMUNOLOGICAL REVIEWS

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma

(2015) Mariano Francesco Caratozzolo et al.   Oncotarget

Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy

(2014) Yuk Yuen Lan et al.   Cell Reports

p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis

(2013) Rubeta N. Matin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High expression of p63 is correlated to poor prognosis in squamous cell carcinoma of the tongue

(2013) Lotta Loljung et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

TRIM8 modulates p53 activity to dictate cell cycle arrest

(2012) Mariano Francesco Caratozzolo et al.   CELL CYCLE

The miR-17∼92 family regulates the response to Toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes

(2012) R Bomben et al.   LEUKEMIA

Nucleo-Cytoplasmic Trafficking of TRIM8, a Novel Oncogene, Is Involved in Positive Regulation of TNF Induced NF-κB Pathway

(2012) Dhanendra Tomar et al.   PLoS One

TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells

(2011) Fumihiko Okumura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3

(2011) Olga A. Guryanova et al.   CANCER CELL

Linear polyubiquitin chains

(2011) Kazuhiro Iwai   CELL CYCLE

Tripartite motif 8 (TRIM8) modulates TNF - and IL-1 -triggered NF- B activation by targeting TAK1 for K63-linked polyubiquitination

(2011) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

(2010) F. Okumura et al.   JOURNAL OF CELL SCIENCE

Overexpression of p63 is associated with radiation resistance and prognosis in oral squamous cell carcinoma

(2010) Maximilian Moergel et al.   ORAL ONCOLOGY

p53-mediated neuronal cell death in ischemic brain injury

(2010) Li-Zhi Hong et al.   Neuroscience Bulletin

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

(2009) Heehyoung Lee et al.   CANCER CELL

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Dynamic Epigenetic Regulation of the Oct4 and Nanog Regulatory Regions during Neural Differentiation in Rhesus Nuclear Transfer Embryonic Stem Cells

(2009) Kai Wang et al.   Cloning Stem Cells

Autophagy: Basic Principles and Relevance to Disease

(2008) Mondira Kundu et al.   Annual Review of Pathology-Mechanisms of Disease