TRIM proteins and diseases

Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity

(2016) Marios G Koliopoulos et al.   EMBO JOURNAL

Impact of TRIM5α in vivo

(2015) Emi E. Nakayama et al.   AIDS

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

(2015) G. Manokaran et al.   SCIENCE

TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin

(2015) Yasushi Masuda et al.   Nature Communications

The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ

(2015) Masashi Watanabe et al.   eLife

Structural insights into the TRIM family of ubiquitin E3 ligases

(2014) Yang Li et al.   CELL RESEARCH

The E3 Ubiquitin Ligase MID1 Catalyzes Ubiquitination and Cleavage of Fu

(2014) Susann Schweiger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice

(2014) David C. Goldstone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer

(2014) J. G. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ubiquitin-Specific Protease USP15 Promotes RIG-I-Mediated Antiviral Signaling by Deubiquitylating TRIM25

(2014) E.-K. Pauli et al.   Science Signaling

RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation

(2013) James T Lee et al.   CELL RESEARCH

Deficiency of the E3 ubiquitin ligase TRIM2 in early-onset axonal neuropathy

(2013) E. Ylikallio et al.   HUMAN MOLECULAR GENETICS

Targeted Deep Resequencing IdentifiesMID2Mutation for X-Linked Intellectual Disability with Varied Disease Severity in a Large Kindred from India

(2013) Thenral S. Geetha et al.   HUMAN MUTATION

Common genetic variants on 1p13.2 associate with risk of autism

(2013) K Xia et al.   MOLECULAR PSYCHIATRY

Human Molecular Genetic and Functional Studies Identify TRIM63 , Encoding Muscle RING Finger Protein 1, as a Novel Gene for Human Hypertrophic Cardiomyopathy

(2012) Suet Nee Chen et al.   CIRCULATION RESEARCH

Intrinsic Protein-Protein Interaction-mediated and Chaperonin-assisted Sequential Assembly of Stable Bardet-Biedl Syndrome Protein Complex, the BBSome

(2012) Qihong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells

(2012) T. Sato et al.   JOURNAL OF CELL SCIENCE

TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling

(2012) Markus G Grütter et al.   Current Opinion in Virology

Genome-wide association studies of cerebral white matter lesion burden

(2011) Myriam Fornage et al.   ANNALS OF NEUROLOGY

Obesity related methylation changes in DNA of peripheral blood leukocytes

(2011) Xiaoling Wang et al.   BMC Medicine

The TRIM Family Protein KAP1 Inhibits HIV-1 Integration

(2011) Awatef Allouch et al.   Cell Host & Microbe

TRIM family: Pleiotropy and diversification through homomultimer and heteromultimer formation

(2011) Luisa M. Napolitano et al.   IUBMB LIFE

Exome sequencing supports a de novo mutational paradigm for schizophrenia

(2011) Bin Xu et al.   NATURE GENETICS

Genome-wide association identifies three new susceptibility loci for Paget's disease of bone

(2011) Omar M E Albagha et al.   NATURE GENETICS

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1

(2011) Bjørn A. Nexø et al.   PLoS One

Rare Copy Number Variation Discovery and Cross-Disorder Comparisons Identify Risk Genes for ADHD

(2011) A. C. Lionel et al.   Science Translational Medicine

The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: Evidence from a large collaborative study totaling 4,963 Subjects

(2010) Thais S. Rizzi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

(2010) F. Okumura et al.   JOURNAL OF CELL SCIENCE

Evaluation of common mutations in the Mediterranean fever gene in Multiple Sclerosis patients: Is it a susceptibility gene?

(2010) Aysun Unal et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases

(2010) Jennifer M. Doyle et al.   MOLECULAR CELL

GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia

(2010) X Chen et al.   MOLECULAR PSYCHIATRY

TRIM31 interacts with p52 Shc and inhibits Src-induced anchorage-independent growth

(2009) Masashi Watanabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells

(2009) Misato Kikuchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia

(2009) Daniel Martins-de-Souza et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Tripartite Motif Protein 32 Facilitates Cell Growth and Migration via Degradation of Abl-Interactor 2

(2008) S. Kano et al.   CANCER RESEARCH

Williams–Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase

(2008) Lucia Micale et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

(2008) Sergio E. Baranzini et al.   HUMAN MOLECULAR GENETICS