TRIM Proteins in Inflammation: from Expression to Emerging Regulatory Mechanisms

Inhibition of TRIM8 restrains ischaemia-reperfusion-mediated cerebral injury by regulation of NF-κB activation associated inflammation and apoptosis

(2020) Xue Bai et al.   EXPERIMENTAL CELL RESEARCH

TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis

(2020) Yosuke Kunishita et al.   Frontiers in Immunology

Upregulated E3 ligase tripartite motif‐containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor‐κB p65 subunit and promotes inflammation in keratinocytes

(2020) L. Yang et al.   BRITISH JOURNAL OF DERMATOLOGY

Cannabinoids drive Th17 cell differentiation in patients with rheumatic autoimmune diseases

(2020) Konstantin Kotschenreuther et al.   Cellular & Molecular Immunology

TRIM21 Aggravates Herpes Simplex Virus Epithelial Keratitis by Attenuating STING-IRF3-Mediated Type I Interferon Signaling

(2020) Tianchang Tan et al.   Frontiers in Microbiology

Gene–Dose Effect of MEFV Gain-of-Function Mutations Determines ex vivo Neutrophil Activation in Familial Mediterranean Fever

(2020) Iris Stoler et al.   Frontiers in Immunology

C-Cbl negatively regulates TRAF6-mediated NF-κB activation by promoting K48-linked polyubiquitination of TRAF6

(2019) Hyun-Duk Jang et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription

(2019) Min Wu et al.   FISH & SHELLFISH IMMUNOLOGY

Trim47 is a critical regulator of cerebral ischemia-reperfusion injury through regulating apoptosis and inflammation

(2019) Miao-Qing Hao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An E3 ubiquitin ligase TRIM9 is involved in WSSV infection via interaction with β-TrCP

(2019) Mingzhe Sun et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection

(2019) Larisa I Labzin et al.   EMBO JOURNAL

Differential expression of inflammasome regulatory transcripts in periodontal disease

(2019) Kübra Aral et al.   JOURNAL OF PERIODONTOLOGY

Decoding inflammation, its causes, genomic responses, and emerging countermeasures

(2019) Jacek Hawiger et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Role reversal: adaptive immunity instructs inflammasome activation for anti‐viral defence

(2019) Rebecca C Coll   EMBO JOURNAL

TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells

(2019) Ghizlane Maarifi et al.   Science Advances

TRIM38 regulates NF-κB activation through TAB2 degradation in osteoclast and osteoblast differentiation

(2018) Kabsun Kim et al.   BONE

E3 ligase Trim21 ubiquitylates and stabilizes Keratin 17 to induce STAT3 activation in psoriasis

(2018) Luting Yang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Type I interferon in rheumatic diseases

(2018) Theresa L. Wampler Muskardin et al.   Nature Reviews Rheumatology

The Sjögren's syndrome-associated autoantigen Ro52/TRIM21 modulates follicular B cell homeostasis and immunoglobulin production

(2018) Susanna Brauner et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

TRIM21 is important in the early phase of inflammation in the imiquimod-induced psoriasis-like skin inflammation mouse model

(2017) Hanne Vinter et al.   EXPERIMENTAL DERMATOLOGY

Tripartite motif-containing (TRIM) 21 negatively regulates intestinal mucosal inflammation through inhibiting T H 1/T H 17 cell differentiation in patients with inflammatory bowel diseases

(2017) Guangxi Zhou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Trim32 Deficiency Enhances Th2 Immunity and Predisposes to Features of Atopic Dermatitis

(2017) Yuangang Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet’s disease

(2017) Yuri Ahn et al.   Scientific Reports

Cellular and Molecular Dynamics of Th17 Differentiation and its Developmental Plasticity in the Intestinal Immune Response

(2017) Suniti Bhaumik et al.   Frontiers in Immunology

TRIM-directed selective autophagy regulates immune activation

(2016) Tomonori Kimura et al.   Autophagy

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

T-cell–intrinsic Tif1α/Trim24 regulates IL-1R expression on TH2 cells and TH2 cell-mediated airway allergy

(2016) Jimena Perez-Lloret et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoinflammatory Skin Disorders: The Inflammasome in Focus

(2016) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

Dysregulated production of interleukin-1β upon activation of the NLRP3 inflammasome in patients with familial Mediterranean fever

(2015) Argyro Repa et al.   HUMAN IMMUNOLOGY

Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF- B Pathways along with TNFR-Associated Factor 6

(2015) T.-H. Chang et al.   JOURNAL OF IMMUNOLOGY

TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms

(2015) Ming-Ming Hu et al.   JOURNAL OF IMMUNOLOGY

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-  Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

(2014) R. Higgs et al.   JOURNAL OF IMMUNOLOGY

The E3 Ubiquitin Ligase Tripartite Motif 33 Is Essential for Cytosolic RNA–Induced NLRP3 Inflammasome Activation

(2014) Leiyun Weng et al.   JOURNAL OF IMMUNOLOGY

TRIM38 inhibits TNF - and IL-1 -triggered NF- B activation by mediating lysosome-dependent degradation of TAB2/3

(2014) M.-M. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9

(2014) Mude Shi et al.   Nature Communications

The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome

(2013) Hiroki Mitoma et al.   IMMUNITY

Network Analysis Reveals Functional Cross-links between Disease and Inflammation Genes

(2013) Yunpeng Zhang et al.   Scientific Reports

Estrogen Receptor α Regulates Tripartite Motif-Containing Protein 21 Expression, Contributing to Dysregulated Cytokine Production in Systemic Lupus Erythematosus

(2013) Siobhán Smith et al.   Arthritis & Rheumatology

TRIM22 inhibits the TRAF6-stimulated NF-κB pathway by targeting TAB2 for degradation

(2013) Hui Qiu et al.   VIROLOGICA SINICA

TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways

(2012) Takeshi Kondo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation

(2012) Mio Shibata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

E3 Ubiquitin Ligase Tripartite Motif 38 Negatively Regulates TLR-Mediated Immune Responses by Proteasomal Degradation of TNF Receptor-Associated Factor 6 in Macrophages

(2012) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

Tripartite Motif-Containing Protein 38 Negatively Regulates TLR3/4- and RIG-I-Mediated IFN-  Production and Antiviral Response by Targeting NAP1

(2012) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

Tyrosine Phosphorylation of the E3 Ubiquitin Ligase TRIM21 Positively Regulates Interaction with IRF3 and Hence TRIM21 Activity

(2012) Kevin B. Stacey et al.   PLoS One

TRIM38 Negatively Regulates TLR3-Mediated IFN-β Signaling by Targeting TRIF for Degradation

(2012) Qinghua Xue et al.   PLoS One

TRIM40 promotes neddylation of IKK  and is downregulated in gastrointestinal cancers

(2011) K. Noguchi et al.   CARCINOGENESIS

TRIM39 and RNF39 are associated with Behçet’s disease independently of HLA-B∗51 and -A∗26

(2010) Riho Kurata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tripartite-Motif Protein 30 Negatively Regulates NLRP3 Inflammasome Activation by Modulating Reactive Oxygen Species Production

(2010) Y. Hu et al.   JOURNAL OF IMMUNOLOGY

Regulation of the Psoriatic Chemokine CCL20 by E3 Ligases Trim32 and Piasy in Keratinocytes

(2010) Yuangang Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Downregulation of active IKKβ by Ro52-mediated autophagy

(2010) Motoko Niida et al.   MOLECULAR IMMUNOLOGY

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway

(2009) Alexander Espinosa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting TAB2 and TAB3 for degradation

(2008) Mude Shi et al.   NATURE IMMUNOLOGY