Synthesis, Characterization, Molecular Docking, Acetylcholinesterase and α‐Glycosidase Inhibition Profiles of Nitrogen‐Based Novel Heterocyclic Compounds

Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer’s disease

(2021) Shoaib Manzoor et al.   BIOORGANIC CHEMISTRY

Effects of some phenolic compounds on the inhibition of α-glycosidase enzyme-immobilized on Pluronic®F127 micelles: An in vitro and in silico study

(2021) Solomon Bezabeh Kassa et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

(2021) Hong Sun et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Potent Acetylcholinesterase Inhibitors: Potential Drugs for Alzheimer’s Disease

(2020) Hulya Akıncıoğlu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A Novel Ag-N-heterocyclic Carbene Complex Bearing the Hydroxyethyl Ligand: Synthesis, Characterization, Crystal and Spectral Structures and Bioactivity Properties

(2020) Aydin Aktas et al.   Crystals

A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications

(2020) Nagaraju Kerru et al.   MOLECULES

Determination of the inhibition profiles of pyrazolyl–thiazole derivatives against aldose reductase and α‐glycosidase and molecular docking studies

(2020) Yeliz Demir et al.   ARCHIV DER PHARMAZIE

Synthesis and antioxidant activities of phenol derivatives from 1,6-bis(dimethoxyphenyl)hexane-1,6-dione

(2020) Tekin Artunc et al.   BIOORGANIC CHEMISTRY

Novel propanolamine derivatives attached to 2-metoxifenol moiety: Synthesis, characterization, biological properties, and molecular docking studies

(2020) Hayriye Genc Bilgicli et al.   BIOORGANIC CHEMISTRY

Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs

(2020) Nebih Lolak et al.   BIOORGANIC CHEMISTRY

Novel functionally substituted esters based on sodium diethyldithiocarbamate derivatives: Synthesis, characterization, biological activity and molecular docking studies

(2020) Alverdi Karimov et al.   BIOORGANIC CHEMISTRY

Benzenesulfonamide derivatives as potent acetylcholinesterase, α-glycosidase, and glutathione S-transferase inhibitors: biological evaluation and molecular docking studies

(2020) Parham Taslimi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Synthesis of water soluble tetra-substituted phthalocyanines: Investigation of DNA cleavage, cytotoxic effects and metabolic enzymes inhibition

(2020) Armağan Günsel et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis, characterization, photo-physicochemical and biological properties of water-soluble tetra-substituted phthalocyanines: Antidiabetic, anticancer and anticholinergic potentials

(2020) Armağan Günsel et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY

Synthesis of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds – Determination of their carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibition properties

(2020) İlhami Gülçin et al.   BIOORGANIC CHEMISTRY

Synthesis, characterization, crystal structure and bioactivity properties of the benzimidazole-functionalized PEPPSI type of Pd(II)NHC complexes

(2020) Semra Daşgın et al.   JOURNAL OF MOLECULAR STRUCTURE

Anti-acetylcholinesterase and toxicity against Artemia salina of chitosan microparticles loaded with essential oils of Cymbopogon flexuosus, Pelargonium x ssp and Copaifera officinalis

(2020) Laysa Rocha Lima et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Phenolic compounds of Eugenia involucrata (Myrtaceae) extracts and associated antioxidant and inhibitory effects on acetylcholinesterase and α-glucosidase

(2020) Andreza Cipriani et al.   NATURAL PRODUCT RESEARCH

Synthesis, characterization and bioactivities of dative donor ligand N-heterocyclic carbene (NHC) precursors and their Ag(I)NHC coordination compounds

(2020) Ali Kazancı et al.   POLYHEDRON

Probing 4-(diethylamino)-salicylaldehyde-based thiosemicarbazones as multi-target directed ligands against cholinesterases, carbonic anhydrases and α-glycosidase enzymes

(2020) Sadaf Hashmi et al.   BIOORGANIC CHEMISTRY

Quantum chemical study of thiaozole derivatives as corrosion inhibitors based on density functional theory

(2020) Burak Tüzün et al.   Arabian Journal of Chemistry

Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer’s Disease

(2019) Minky Son et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Influence of Some Nonsteroidal Anti-inflammatory Drugs on Metabolic Enzymes of Aldose Reductase, Sorbitol Dehydrogenase, and α-Glycosidase: a Perspective for Metabolic Disorders

(2019) Yeliz Demir et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Synthesis, characterization, biological evaluation, and molecular docking studies of some piperonyl‐based 4‐thiazolidinone derivatives

(2019) Hayriye Genc Bilgicli et al.   ARCHIV DER PHARMAZIE

Heterocycles in Medicinal Chemistry

(2019) Josef Jampilek   MOLECULES

Water mediated synthesis of 6-amino-5-cyano-2-oxo-N-(pyridin-2-yl)-4-(p-tolyl)-2H-[1,2′-bipyridine]-3-carboxamide and 6-amino-5-cyano-4-(4-fluorophenyl)-2-oxo-N-(pyridin-2-yl)-2H-[1,2′-bipyridine]-3-carboxamide – An experimental and computational studies with non-linear optical (NLO) and molecular docking analyses

(2019) Ramasamy Jayarajan et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Synthesis, characterization and biological evaluation of N ‐substituted triazinane‐2‐thiones and theoretical–experimental mechanism of condensation reaction

(2019) Afsun Sujayev et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Novel tribenzylaminobenzolsulphonylimine based on their pyrazine and pyridazines: Synthesis, characterization, antidiabetic, anticancer, anticholinergic, and molecular docking studies

(2019) Gulnar Mamedova et al.   BIOORGANIC CHEMISTRY

Novel carvacrol based new oxypropanolamine derivatives: Design, synthesis, characterization, biological evaluation, and molecular docking studies

(2019) Arlinda Bytyqi-Damoni et al.   JOURNAL OF MOLECULAR STRUCTURE

meta -Cyanobenzyl substituted benzimidazolium salts: Synthesis, characterization, crystal structure and carbonic anhydrase, α-glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory properties

(2018) Ferhat Türker et al.   ARCHIV DER PHARMAZIE

PCl 3 - and organometallic-free synthesis of tris(2-picolyl)phosphine oxide from elemental phosphorus and 2-(chloromethyl)pyridine hydrochloride

(2018) Svetlana F. Malysheva et al.   TETRAHEDRON LETTERS

Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia

(2018) Parham Taslimi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes

(2018) İlhami Gulçin et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Screening the in vitro antioxidant, antimicrobial, anticholinesterase, antidiabetic activities of endemic Achillea cucullata (Asteraceae) ethanol extract

(2018) N. Eruygur et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Biological properties of phenolic compound extracts in selected Algerian honeys—The inhibition of acetylcholinesterase and α-glucosidase activities

(2018) Hicham Zaidi et al.   European Journal of Integrative Medicine

Combining in silico and in vitro approaches to evaluate the acetylcholinesterase inhibitory profile of some commercially available flavonoids in the management of Alzheimer’s disease

(2017) Asokkumar Kuppusamy et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Synthesis of 2-amino-3-cyanopyridine derivatives and investigation of their carbonic anhydrase inhibition effects

(2017) Aliye Altundas et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base

(2017) Parham Taslimi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Evaluation of Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors as Potential Anti-Alzheimer’s Disease Agents Using Pharmacophore, 3D-QSAR, and Molecular Docking Approaches

(2017) Xiaocong Pang et al.   MOLECULES

Pyrrole: An emerging scaffold for construction of valuable therapeutic agents

(2016) Somnath S. Gholap   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase

(2016) Dilan Ozmen Ozgun et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions

(2016) Fadime Özbey et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities

(2016) Emin Garibov et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A One-Pot Synthesis of 2-Aminopyrimidines from Ketones, Arylacetylenes, and Guanidine

(2016) Elena Yu. Schmidt et al.   JOURNAL OF ORGANIC CHEMISTRY

Oxidation of cyanobenzocycloheptatrienes: Synthesis, photooxygenation reaction and carbonic anhydrase isoenzymes inhibition properties of some new benzotropone derivatives

(2014) Murat Güney et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrrolizines: Promising scaffolds for anticancer drugs

(2013) Amany Belal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rapid screening and identification ofα-glucosidase inhibitors from mulberry leaves using enzyme-immobilized magnetic beads coupled with HPLC/MS and NMR

(2012) Yi Tao et al.   BIOMEDICAL CHROMATOGRAPHY

The Role of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) in Alzheimer’s Disease

(2009) Qingguang Jiang et al.   CNS DRUGS