Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer’s Disease

g_mmpbsa—A GROMACS Tool for High-Throughput MM-PBSA Calculations

(2014) Rashmi Kumari et al.   Journal of Chemical Information and Modeling

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

(2013) Florian Nachon et al.   BIOCHEMICAL JOURNAL

Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease

(2012) Slavka Hamulakova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New Tacrine–4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Cholinergic, Antioxidant, and β-Amyloid-Reducing Properties

(2012) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Huprine–Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer’s and Prion Diseases

(2011) Carles Galdeano et al.   JOURNAL OF MEDICINAL CHEMISTRY

The cholinergic system, circadian rhythmicity, and time memory

(2010) R.A. Hut et al.   BEHAVIOURAL BRAIN RESEARCH

Synthesis and structure–activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors

(2009) Cyril Ronco et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties

(2008) Rafael León et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation

(2008) Pelayo Camps et al.   JOURNAL OF MEDICINAL CHEMISTRY