Probing 4-(diethylamino)-salicylaldehyde-based thiosemicarbazones as multi-target directed ligands against cholinesterases, carbonic anhydrases and α-glycosidase enzymes

A study on the Effects of Inhibition Mechanism of Curcumin, Quercetin, and Resveratrol on Human Glutathione Reductase through In Vitro and In Silico Approaches

(2020) Pınar Güller et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Type 3 Diabetes and Its Role Implications in Alzheimer’s Disease

(2020) Thuy Trang Nguyen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis of novel organohalogen chalcone derivatives and screening of their molecular docking study and some enzymes inhibition effects

(2020) Serdar Burmaoglu et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis and urease inhibitory activity of 1,4-benzodioxane-based thiosemicarbazones: Biochemical and computational approach

(2020) Muhammad Tariq Shehzad et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis, crystal structure, and biological evaluation of optically active 2-amino-4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H -chromen-3-carbonitriles: Antiepileptic, antidiabetic, and anticholinergics potentials

(2019) Abel Maharramov et al.   ARCHIV DER PHARMAZIE

Phytochemical content, antioxidant activity, and enzyme inhibition effect of Salvia eriophora Boiss. & Kotschy against acetylcholinesterase, α-amylase, butyrylcholinesterase, and α-glycosidase enzymes

(2019) Ercan Bursal et al.   JOURNAL OF FOOD BIOCHEMISTRY

Synthesis and investigation of anticancer, antibacterial activities and carbonic anhydrase, acetylcholinesterase inhibition profiles of novel (3aR,4S,7R,7aS)-2-[4-[1-acetyl-5-(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-diones

(2019) Umit M. Kocyigit et al.   MONATSHEFTE FUR CHEMIE

Activation and inhibition effects of some natural products on human cytosolic CAI and CAII

(2019) Sevki Adem et al.   MEDICINAL CHEMISTRY RESEARCH

Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme

(2019) Atilla Akdemir et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Target Enzyme in Alzheimer’s Disease:Acetylcholinesterase Inhibitors

(2019) Mridula Saxena et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Synthesis, characterization, molecular docking and biological activities of novel pyrazoline derivatives

(2019) Fikret Turkan et al.   ARCHIV DER PHARMAZIE

Synthesis of Oxazolidinone from Enantiomerically Enriched Allylic Alcohols and Determination of Their Molecular Docking and Biologic Activities

(2019) Ufuk Atmaca et al.   BIOORGANIC CHEMISTRY

Synthesis and biological evaluation of bromophenol derivatives with cyclopropyl moiety: Ring opening of cyclopropane with monoester

(2019) Murat Boztas et al.   BIOORGANIC CHEMISTRY

Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes

(2019) Kaan Kucukoglu et al.   BIOORGANIC CHEMISTRY

Synthesis and characterization of new thiosemicarbazones, as potent urease inhibitors: In vitro and in silico studies

(2019) Muhammad Islam et al.   BIOORGANIC CHEMISTRY

Efficient synthesis and anti-bovine viral diarrhea virus evaluation of 5-(aryldiazo)salicylaldehyde thiosemicarbazone derivatives

(2019) Samir Y. Abbas et al.   SYNTHETIC COMMUNICATIONS

The green synthesis and molecular docking of novel N-substituted rhodanines as effective inhibitors for carbonic anhydrase and acetylcholinesterase enzymes

(2019) Sinan Bayindir et al.   BIOORGANIC CHEMISTRY

New thiosemicarbazide-1,2,3-triazole hybrids as potent α-glucosidase inhibitors: Design, synthesis, and biological evaluation

(2019) Zohreh Bakherad et al.   JOURNAL OF MOLECULAR STRUCTURE

Pyrazole[3,4-d]pyridazine derivatives: Molecular docking and explore of acetylcholinesterase and carbonic anhydrase enzymes inhibitors as anticholinergics potentials

(2019) Parham Taslimi et al.   BIOORGANIC CHEMISTRY

Synthesis, characterization and molecular docking of some novel hydrazonothiazolines as urease inhibitors

(2019) Muhammad Tariq Shehzad et al.   BIOORGANIC CHEMISTRY

Novel 2-aminopyridine liganded Pd(II) N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure and bioactivity properties

(2019) Fatoş Erdemir et al.   BIOORGANIC CHEMISTRY

Butyrylcholinesterase: A Multifaceted Pharmacological Target and Tool

(2019) Zhe Ying Ha et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

In vitro effects of standard antioxidants on lactoperoxidase enzyme–A molecular docking approach

(2019) Ramazan Kalin et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Continued exploration and tail approach synthesis of benzenesulfonamides containing triazole and dual triazole moieties as carbonic anhydrase I, II, IV and IX inhibitors

(2019) Lalit Vats et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of a cheminformatics platform for selectivity analyses of carbonic anhydrase inhibitors

(2019) Giulio Poli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel zinc compound with thiosemicarbazone of glyoxylic acid: Synthesis, crystal structure, and bioactivity properties

(2019) Mansura Huseynova et al.   JOURNAL OF MOLECULAR STRUCTURE

Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development

(2018) Petra Heffeter et al.   ANTIOXIDANTS & REDOX SIGNALING

Novel multi-target directed ligand-based strategies for reducing neuroinflammation in Alzheimer's disease

(2018) Tyler Joseph Wenzel et al.   LIFE SCIENCES

Synthesis, in vitro $$\alpha $$α-glucosidase inhibitory activity, and in silico study of (E)-thiosemicarbazones and (E)-2-(2-(arylmethylene)hydrazinyl)-4-arylthiazole derivatives

(2018) Muhammad Ali et al.   MOLECULAR DIVERSITY

Bioactive Compound Collections: From Design to Target Identification

(2018) Luca Laraia et al.   Chem

Screening the in vitro antioxidant, antimicrobial, anticholinesterase, antidiabetic activities of endemic Achillea cucullata (Asteraceae) ethanol extract

(2018) N. Eruygur et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes

(2018) Yeliz Demir et al.   ARCHIV DER PHARMAZIE

The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach

(2018) Cuneyt Caglayan et al.   JOURNAL OF FOOD BIOCHEMISTRY

Imidazolinium chloride salts bearing wingtip groups: Synthesis, molecular docking and metabolic enzymes inhibition

(2018) Beyhan Yiğit et al.   JOURNAL OF MOLECULAR STRUCTURE

Xanthenone-based hydrazones as potent α-glucosidase inhibitors: Synthesis, solid state self-assembly and in silico studies

(2018) Qamar-un-Nisa Tariq et al.   BIOORGANIC CHEMISTRY

Synthesis, characterization, crystal structure of the coordination polymer Zn(II) with thiosemicarbazone of glyoxalic acid and their inhibitory properties against some metabolic enzymes

(2018) Mansura Huseynova et al.   BIOORGANIC CHEMISTRY

The first synthesis, carbonic anhydrase inhibition and anticholinergic activities of some bromophenol derivatives with S including natural products

(2018) Cetin Bayrak et al.   BIOORGANIC CHEMISTRY

A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease

(2017) Duraippandi Palanimuthu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery

(2017) Balaguru Ravikumar et al.   Expert Opinion on Drug Discovery

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

(2017) Urban Košak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, structural, DFT studies, docking and antibacterial activity of a xanthene based hydrazone ligand

(2017) Saira Naseem et al.   JOURNAL OF MOLECULAR STRUCTURE

Multitarget Drug Discovery and Polypharmacology

(2016) Maria Laura Bolognesi et al.   ChemMedChem

Advances in structure-based drug discovery of carbonic anhydrase inhibitors

(2016) Claudiu T. Supuran   Expert Opinion on Drug Discovery

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors

(2016) Claudia Melis et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis, spectroscopy, structures and antimicrobial activity of mixed-ligand zinc(ii) complexes of 5-nitro-salicylaldehyde thiosemicarbazones

(2016) Shikha Indoria et al.   NEW JOURNAL OF CHEMISTRY

Synthesis, biological evaluation and molecular docking of N-phenyl thiosemicarbazones as urease inhibitors

(2015) Abdul Hameed et al.   BIOORGANIC CHEMISTRY

X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors

(2015) Jekaterina Ivanova et al.   CHEMICAL COMMUNICATIONS

The human carbonic anhydrase isoenzymes I and II (hCA I and II) inhibition effects of trimethoxyindane derivatives

(2015) Parham Taslimi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Me3N-promoted synthesis of 2,3,4,4a-tetrahydroxanthen-1-one: preparation of thiosemicarbazone derivatives, their solid state self-assembly and antimicrobial properties

(2015) Aminah Hameed et al.   NEW JOURNAL OF CHEMISTRY

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

α-Glucosidase inhibitory constituents from Chrozophora plicata

(2013) Asia Tabussum et al.   Phytochemistry Letters

Structures of Human Acetylcholinesterase Bound to Dihydrotanshinone I and Territrem B Show Peripheral Site Flexibility

(2013) Jonah Cheung et al.   ACS Medicinal Chemistry Letters

Rapid screening and identification ofα-glucosidase inhibitors from mulberry leaves using enzyme-immobilized magnetic beads coupled with HPLC/MS and NMR

(2012) Yi Tao et al.   BIOMEDICAL CHROMATOGRAPHY

The Medicinal Chemistry of Novel Iron Chelators for the Treatment of Cancer

(2011) Zaklina Kovacevic et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

New Glucosidase Inhibitors from an Ayurvedic Herbal Treatment for Type 2 Diabetes: Structures and Inhibition of Human Intestinal Maltase-Glucoamylase with Compounds fromSalacia reticulata

(2009) Lyann Sim et al.   BIOCHEMISTRY

Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors

(2009) Yu Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel thiosemicarbazone derivatives as potential antitumor agents: Synthesis, physicochemical and structural properties, DNA interactions and antiproliferative activity

(2008) Ivica Đilović et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY