Astragaloside-IV alleviates high glucose-induced ferroptosis in retinal pigment epithelial cells by disrupting the expression of miR-138-5p/Sirt1/Nrf2

Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling

(2021) Li-Fei Luo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

TRIM46 contributes to high glucose-induced ferroptosis and cell growth inhibition in human retinal capillary endothelial cells by facilitating GPX4 ubiquitination

(2021) Jingfa Zhang et al.   EXPERIMENTAL CELL RESEARCH

Astragalus polysaccharide attenuates metabolic memory-triggered ER stress and apoptosis via regulation of miR-204/SIRT1 axis in retinal pigment epithelial cells

(2020) Qing-Hua Peng et al.   BIOSCIENCE REPORTS

Early astragaloside IV administration attenuates experimental autoimmune encephalomyelitis in mice by suppressing the maturation and function of dendritic cells

(2020) Liu Yang et al.   LIFE SCIENCES

Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia

(2020) Man Li et al.   ACTA PHARMACOLOGICA SINICA

Astragaloside IV protects retinal pigment epithelial cells from apoptosis by upregulating miR‑128 expression in diabetic rats

(2020) Tao Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer

(2020) Shanqi Guo et al.   Frontiers in Pharmacology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Curcumin prevents high glucose damage in retinal pigment epithelial cells through ERK1/2-mediated activation of the Nrf2/HO-1 pathway

(2019) Claudio Bucolo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Astragaloside IV Alleviates Ammonia-Induced Apoptosis and Oxidative Stress in Bovine Mammary Epithelial Cells

(2019) Fengge Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Safety, efficacy and tumor mutational burden as a biomarker of overall survival benefit in chemo-refractory gastric cancer treated with toripalimab, a PD-1 antibody in phase Ib/II clinical trial NCT02915432

(2019) F Wang et al.   ANNALS OF ONCOLOGY

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

(2019) Burak I. Arioz et al.   Frontiers in Immunology

P53/NRF2 mediates SIRT1's protective effect on diabetic nephropathy

(2019) Fuzhe Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Astragaloside IV protects against hyperglycemia-induced vascular endothelial dysfunction by inhibiting oxidative stress and Calpain-1 activation

(2019) Qu Nie et al.   LIFE SCIENCES

CTRP3 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells

(2019) Jian Zhang et al.   Artificial Cells Nanomedicine and Biotechnology

Astragaloside-IV protects H9C2(2-1) cardiomyocytes from high glucose-induced injury via miR-34a-mediated autophagy pathway

(2019) Yaobin Zhu et al.   Artificial Cells Nanomedicine and Biotechnology

Auranofin Mediates Mitochondrial Dysregulation and Inflammatory Cell Death in Human Retinal Pigment Epithelial Cells: Implications of Retinal Neurodegenerative Diseases

(2019) Thangal Yumnamcha et al.   Frontiers in Neuroscience

LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis

(2019) Qing Mao et al.   Stem Cell Research & Therapy

Crocin Alleviates Myocardial Ischemia/Reperfusion-Induced Endoplasmic Reticulum Stress Via Regulation of MIR-34A/SIRT1/NRF2 Pathway

(2018) Xiaowu Wang et al.   SHOCK

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

(2018) Yun Sun et al.   Cell Death & Disease

Astragalosides IV protected the renal tubular epithelial cells from free fatty acids-induced injury by reducing oxidative stress and apoptosis

(2018) Qingqing Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells

(2018) Kiyohito Totsuka et al.   EXPERIMENTAL EYE RESEARCH

Astragaloside suppresses tumor necrosis factor receptor-associated factor 5 signaling pathway and alleviates neurodegenerative changes in retinal pigment epithelial cells induced by isoflurane

(2018) Pei-Jun Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB P65 subunit

(2018) Xiaolei Wang et al.   Drug Design Development and Therapy

LncRNA-MEG3 alleviates high glucose induced inflammation and apoptosis of retina epithelial cells via regulating miR-34a/SIRT1 axis

(2018) Ping Tong et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Effects of diabetic retinopathy on the barrier functions of the retinal pigment epithelium

(2017) Tina Xia et al.   VISION RESEARCH

Astragaloside IV protects rat retinal capillary endothelial cells against high glucose-induced oxidative injury

(2017) Yuan Qiao et al.   Drug Design Development and Therapy

High glucose promotes the migration of retinal pigment epithelial cells through increased oxidative stress and PEDF expression

(2016) Mitra Farnoodian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

MiR-138-5p promotes TNF-α-induced apoptosis in human intervertebral disc degeneration by targeting SIRT1 through PTEN/PI3K/Akt signaling

(2016) Bing Wang et al.   EXPERIMENTAL CELL RESEARCH

Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1

(2015) Jing Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners

(2015) Dong-Il Kim et al.   Oxidative Medicine and Cellular Longevity

Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents

(2014) Minh Truong Do et al.   FREE RADICAL BIOLOGY AND MEDICINE

Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO

(2014) Anle Zhang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Protective Effects of Astragaloside IV on db/db Mice with Diabetic Retinopathy

(2014) Yuzhi Ding et al.   PLoS One

Role of microRNAs in the modulation of diabetic retinopathy

(2014) Rodolfo Mastropasqua et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

The Retinal Pigment Epithelium: Something More than a Constituent of the Blood-Retinal Barrier—Implications for the Pathogenesis of Diabetic Retinopathy

(2010) Rafael Simó et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY