Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia

Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging

(2018) Svetlana M. Stamatovic et al.   NEUROBIOLOGY OF DISEASE

Inhibition of calcium/calmodulin-dependent protein kinase kinase (CaMKK) exacerbates impairment of endothelial cell and blood-brain barrier after stroke

(2018) Ping Sun et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Role of Sirt1 in Ischemic Stroke: Pathogenesis and Therapeutic Strategies

(2018) Jun-Fang Zhang et al.   Frontiers in Neuroscience

Cycloastragenol improves hepatic steatosis by activating farnesoid X receptor signalling

(2017) Ming Gu et al.   PHARMACOLOGICAL RESEARCH

Pharmacokinetics, metabolism, and excretion of cycloastragenol, a potent telomerase activator in rats

(2016) Peng-Kai Ma et al.   XENOBIOTICA

Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium

(2015) Yan Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow

(2015) Yorito Hattori et al.   NEUROREPORT

Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation

(2014) Alexander V. Sirotkin et al.   CELL AND TISSUE RESEARCH

SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage

(2014) Xiao-Ming Zhou et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate

(2013) Jiahui Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

MMP-9 Inhibition: a Therapeutic Strategy in Ischemic Stroke

(2013) Mayank Chaturvedi et al.   MOLECULAR NEUROBIOLOGY

Silent Information Regulator 1 Protects the Brain Against Cerebral Ischemic Damage

(2013) M. Hernandez-Jimenez et al.   STROKE

Pharmacokinetic Evidence on the Contribution of Intestinal Bacterial Conversion to Beneficial Effects of Astragaloside IV, a Marker Compound of Astragali Radix, in Traditional Oral Use of the Herb

(2012) Rui-Na Zhou et al.   Drug Metabolism and Pharmacokinetics

Chronic Valproate Treatment Enhances Postischemic Angiogenesis and Promotes Functional Recovery in a Rat Model of Ischemic Stroke

(2012) Zhifei Wang et al.   STROKE

Cellular and molecular effects of sirtuins in health and disease

(2011) Yoshiyuki Horio et al.   CLINICAL SCIENCE

Acetylation of the Pro-Apoptotic Factor, p53 in the Hippocampus following Cerebral Ischemia and Modulation by Estrogen

(2011) Limor Raz et al.   PLoS One

Protective effects and mechanisms of sirtuins in the nervous system

(2011) Feng Zhang et al.   PROGRESS IN NEUROBIOLOGY

Valproic Acid Attenuates Blood–Brain Barrier Disruption in a Rat Model of Transient Focal Cerebral Ischemia: The Roles of HDAC and MMP-9 Inhibition

(2010) Zhifei Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury

(2010) A Lanzillotta et al.   Cell Death & Disease

Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway

(2009) D. Della-Morte et al.   NEUROSCIENCE

Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability

(2008) G. Ramadori et al.   JOURNAL OF NEUROSCIENCE

Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity

(2008) Jason A. Pfister et al.   PLoS One