Review
Biotechnology & Applied Microbiology
Cheng Zhang, Tianjia Zhang, Tengyu Geng, Xudong Wang, Kaili Lin, Penglai Wang
Summary: Implant-supported dentures are commonly used in patients with dental defects or loss, but pose a risk of failure in patients with systemic diseases such as osteoporosis. Current research has been focusing on bioactive modifications of implants to promote osseointegration, showing promising results in regulating the local osteoporotic microenvironment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katja Andrina Kravanja, Matjaz Finsgar
Summary: The study focuses on the importance of characterization techniques for bioactive coatings for orthopedic implants and describes various advanced analytical techniques used for characterizing the coatings in order to further improve their properties.
Review
Pharmacology & Pharmacy
Wing-Fu Lai, Wing-Tak Wong
Summary: Graphene, with its excellent properties, has been widely studied for biomedical applications. To enhance practical use, future research needs to examine the toxicity in more detail and establish guidelines for standardized experimental conditions to evaluate the performance of graphene-based materials.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Xu Zhang, Xin-Yi Liu, Hao Yang, Jiang-Nan Chen, Ying Lin, Shuang-Yan Han, Qian Cao, Han-Shi Zeng, Jian-Wen Ye
Summary: Bioactive substances (BAS) play a vital role in therapeutic applications. However, their uncontrollable release and instability pose challenges. To address this, biodegradable carrier systems based on micro-nano structures, including polyhydroxyalkanoates (PHA), have been developed to protect and control the release of BAS. This review highlights the developments and applications of PHA-based carrier systems, as well as recent innovations in PHA-based BAS carriers powered by synthetic biology.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Ceramics
Virginia Alessandra Gobbo, Paula Turkki, Cristina Santos Dias Palma, Vijay Singh Parihar, Enrica Verne, Silvia Spriano, Andre Sanches Ribeiro, Vesa P. Hytonen, Jonathan Massera
Summary: Bioactive glasses have high biocompatibility and bioactivity, making them promising for bone tissue regeneration. This study successfully controlled the adsorption of fibronectin and chimeric avidin on glass surfaces by tailoring the surface properties, demonstrating their different affinities and distributions.
CERAMICS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Sabine Stoetzel, Deeksha Malhan, Ute Wild, Christian Helbing, Fathi Hassan, Sameh Attia, Klaus D. Jandt, Christian Heiss, Thaqif El Khassawna
Summary: In this preclinical study, the effects of different bioactive coatings on titanium implants were evaluated using histological analysis and cellular balance assessment. The results showed that the chitosan/gelatin-coated titanium implants exhibited improved bone matrix quality and cellular balance compared to the chitosan/hyaluronic acid-coated and native implants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Oana Gherasim, Gianina Popescu-Pelin, Paula Florian, Madalina Icriverzi, Anca Roseanu, Valentina Mitran, Anisoara Cimpean, Gabriel Socol
Summary: The study successfully loaded ibuprofen into PLGA polymer coatings, demonstrating long-term and stable drug release suitable for surface modification of implantable medical devices. Excellent cytocompatibility was shown in dynamic testing, indicating promising potential for future applications.
Article
Materials Science, Multidisciplinary
N. Aslan, B. Aksakal, B. Dikici, Z. A. Sinirlioglu
Summary: The effect of HA-based coatings reinforced with rGO on porous-Ti6Al4V alloys in terms of electrochemical corrosion and cell viability was investigated. The results showed that rGO reinforcements reduced the corrosion rate of the scaffolds, and the corrosion rate increased as the porosity content of the scaffolds increased. 0.5 and 1.0wt% rGO-HA coating groups had better cell viability.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Multidisciplinary Sciences
Tomoya Soma, Ryotaro Iwasaki, Yuiko Sato, Tami Kobayashi, Eri Ito, Tatsuaki Matsumoto, Atsushi Kimura, Fuka Homma, Keitarou Saiki, Yukihiro Takahashi, Kana Miyamoto, Morio Matsumoto, Masaya Nakamura, Mayu Morita, Ken Ishii, Seiji Asoda, Hiromasa Kawana, Zhu Xingyu, Mamoru Aizawa, Taneaki Nakagawa, Takeshi Miyamoto
Summary: In this study, we demonstrated that silver ion coating on titanium rods exhibited significant antibacterial activity against anaerobic bacteria Porphyromonas gingivalis. The silver-coated rods effectively inhibited P. gingivalis infection in vivo, reduced osteonecrosis caused by infectious osteomyelitis, and decreased the levels of inflammatory factors C-reactive protein and IL-6. Thus, silver ion coating could be a promising therapeutic option to prevent associated infections in anaerobic conditions.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Physical
Maria P. Nikolova, Margarita D. Apostolova
Summary: In orthopedic surgery, implants are almost always required to fix bones, and metals are commonly used for load-bearing applications due to their physical and mechanical properties. However, metallic implants face challenges such as low biocompatibility, excessive wear, low corrosion resistance, infections, and shielding stress. Various coatings have been applied to improve their in vitro and in vivo performance, creating composite implants with bioactive, osteogenic, antibacterial, or biodegradable properties when combined with bio-ceramic or polymer coatings. This review systematically examines bioactive and high-performance coatings for metallic bone implants and discusses their biocompatibility. It also provides updates on coating materials and formulations for metallic implants, as well as their production routes. Additionally, methods of enhancing bioactive coating performance through controlled release of bioactive moieties such as growth factors, osteogenic factors, immunomodulatory factors, antibiotics, or other drugs are addressed.
Article
Dentistry, Oral Surgery & Medicine
V Rosa, R. Malhotra, S. Agarwalla, J. L. P. Morin, E. K. Luong-Van, Y. M. Han, R. J. J. Chew, C. J. Seneviratne, N. Silikas, K. S. Tan, C. A. Nijhuis, A. H. Castro Neto
Summary: The study demonstrates that graphene nanocoating (GN) deposited onto dental and orthopedic implants has antimicrobial properties and enhances bone formation, while also maintaining high integrity and quality under different stresses.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Chemistry, Physical
Daniel Robles, Aritza Brizuela, Manuel Fernandez-Dominguez, Javier Gil
Summary: One strategy to combat peri-implantitis is the production of titanium dental implants with a smooth surface near the neck. These hybrid dental implants sacrifice better coronal osseointegration for a smoother surface that inhibits bacterial colonization. This study found that the rough implants had higher surface roughness and exhibited higher corrosion potentials and current densities. Additionally, the release of titanium ions was higher in the rough implants compared to the hybrid and smooth implants.
Article
Dentistry, Oral Surgery & Medicine
Fadi N. Barrak, Siwei Li, Ali A. Mohammed, Connor Myant, Julian R. Jones
Summary: This study assessed the impact of the dissolution products of S53P4 bioactive glass (BG) on the cellular response to dental implant particles. The results showed that the presence of Ti-6Al-4V implant particles induced significant inflammation in all tested cell types. The S53P4 BG dissolution products suppressed the particle-induced inflammation and potentially influenced macrophage polarization behavior.
JOURNAL OF DENTISTRY
(2022)
Review
Engineering, Biomedical
Zhenbing Ji, Yi Wan, Hongwei Wang, Mingzhi Yu, Zihe Zhao, Teng Wang, Guoxuan Ma, Shiyuan Fan, Zhanqiang Liu
Summary: Titanium and its alloys are widely used in bone tissue defect treatment due to their excellent comprehensive properties. However, achieving satisfactory osseointegration and preventing inflammatory responses when implanted into the body has become a new research hotspot. Various surface modification methods have been proposed, but there is a need to classify and compare these methods systematically. This manuscript summarizes and discusses the effect of physical signal regulation (multi-scale composite structure) and chemical signal regulation (bioactive substance) generated by surface modification in promoting osteogenesis and reducing inflammatory responses.
BIOMEDICAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jeong Min Kwak, Jungho Kim, Chung-Sung Lee, Il-Soo Park, Min Lee, Dal-Hee Min, In-Sung Luke Yeo
Summary: Graphene oxide has promoting effects on bone marrow stromal cells and human gingival fibroblasts, significantly enhancing osseointegration on titanium surfaces. Physicochemical modification of titanium surfaces with SLA treatment and GO coating stimulates osteogenic activities of mesenchymal stem cells, improving biocompatibility with connective tissue cells and enhancing bone healing at the bone-implant interface.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Engineering, Biomedical
Weizhen Chen, Wen Li, Kui Xu, Menghuan Li, Liangliang Dai, Xinkun Shen, Yan Hu, Kaiyong Cai
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2018)
Article
Engineering, Biomedical
Weizhen Chen, Kui Xu, Bailong Tao, Liangliang Dai, Yonglin Yu, Caiyun Mu, Xinkun Shen, Yan Hu, Ye He, Kaiyong Cai
ACTA BIOMATERIALIA
(2018)
Article
Chemistry, Physical
Kui Xu, Weizhen Chen, Guanglei Fu, Xianbo Mou, Ruixia Hou, Yabin Zhu, Kaiyong Cai
Article
Materials Science, Multidisciplinary
Kui Xu, Kaiyong Cai
Article
Chemistry, Analytical
Guanglei Fu, Yabin Zhu, Kui Xu, Weihua Wang, Ruixia Hou, Xiujun Li
ANALYTICAL CHEMISTRY
(2019)
Article
Materials Science, Multidisciplinary
Ruixia Hou, Yuxi Wang, Jiali Han, Yabin Zhu, Hua Zhang, Libing Zhang, Liping Li, Kui Xu, Guanglei Fu, Xianbo Mou, Xi Chen, Lu Yang, Lei Nie
MATERIALS RESEARCH EXPRESS
(2020)
Article
Chemistry, Physical
Kui Xu, Mi Zhou, Ming Li, Weizhen Chen, Yabin Zhu, Kaiyong Cai
APPLIED SURFACE SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Liang Huang, Yuxing Zhang, Tao Liao, Kui Xu, Chenxing Jiang, Dinglv Zhuo, Yang Wang, Hui-Min Wen, Jing Wang, Lijiao Ao, Jun Hu
Summary: Exploring signal amplification strategies for lateral flow immunoassay is important for point-of-care testing. A highly-sensitive LFIA platform using magneto-fluorescent assemblies was demonstrated, allowing for detection of low-concentrated targets.
Article
Engineering, Biomedical
Weizhen Chen, Guoliang Xie, Yang Lu, Jiayuan Wang, Baihuan Feng, Qi Wang, Kui Xu, Jiaqi Bao
Summary: This study focuses on the surface modification of metal implants using pitavastatin to enhance bone defect healing through the synergistic osteogenesis-angiogenesis regulation. The researchers constructed multilayer films with osteogenic and angiogenic properties on pure titanium substrates, and found that locally applied pitavastatin dramatically enhanced the osteogenic potential of mesenchymal stem cells (MSCs) and the angiogenic potential of endothelial cells (ECs). Furthermore, the pitavastatin-loaded films were able to regulate the paracrine signaling between MSCs and ECs, indirectly increasing the angiogenic potential of MSCs and the osteogenic potential of ECs. Subcutaneous and femur implantation experiments confirmed that locally released pitavastatin promoted endogenous stem cells and ECs to the implant-bone interface, facilitating coupled osteogenesis and angiogenesis, and enhancing peri-implant osseointegration.
Article
Engineering, Environmental
Lijiao Ao, Tao Liao, Liang Huang, Shan Lin, Kui Xu, Jiangtao Ma, Shaorong Qiu, Xiangyu Wang, Qiqing Zhang
Summary: This study developed a highly sensitive and portable multi-target serum cancer biomarker detection method. By using NIR-II emitting quantum dots and three-dimensional distribution assembly, the sensitivity and fluorescence signals of the test strip were successfully enhanced. With this method, simultaneous detection and quantitative analysis of CEA, Cyfra21-1, and NSE tumor biomarkers were achieved, with high sensitivity and specificity demonstrated in lung cancer patients and healthy individuals.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Kui Xu, Caiyun Mu, Chi Zhang, Sijie Deng, Shan Lin, Linlin Zheng, Weizhen Chen, Qiqing Zhang
Summary: A multifunctional coating based on gallium (III)-phenolic networks was developed by immersing implants into a solution of tannic acids (TAs) and gallium ions. The coating exhibited excellent near-infrared photothermal property and broad-spectrum antibacterial ability. It also reduced intracellular ROS levels and enhanced osseointegration of the implants by promoting osteogenesis and inhibiting osteoclastogenesis.
Article
Medicine, Research & Experimental
Wei Yang, Xiongfei Sun, Shuai Liu, Ying Xu, Yunlei Li, Xiaoru Huang, Kaiqing Liu, Longyi Mao, Shasha Min, Linjiang Liu, Shi Li, Yuqi Zhu, Yu Zhang, Xina Xie, Kui Xu, Changqing Sun, Jie Yan, Zesong Li
Summary: The clinical treatment of AML is often toxic and limited in efficacy, therefore, novel therapeutic strategies are urgently needed. Small-molecule inhibitors, such as the TLR8 agonist Motolimod (MTL), show high specificity and low off-target toxicity, and have strong potential in tumor therapy. In this study, MTL demonstrated significant anti-AML activity in vitro and in vivo, with minimal effects on normal lymphocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Kui Xu, Sijie Deng, Yabin Zhu, Wei Yang, Weizhen Chen, Liang Huang, Chi Zhang, Ming Li, Lijiao Ao, Yibo Jiang, Xiangyu Wang, Qiqing Zhang
Summary: This study introduces a platelet rich plasma (PRP) loaded multifunctional hydrogel with reactive oxygen species (ROS) and glucose dual-responsive property, which can accelerate diabetic wound healing. The hydrogel possesses several desirable properties and can release cytokines to promote wound healing in an oxidative stress or hyperglycemia state.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Xingyuan Wang, Jiachang Jin, Ruixia Hou, Mi Zhou, Xianbo Mou, Kui Xu, Yabin Zhu, Zhisen Shen, Xingcai Zhang
ACS APPLIED BIO MATERIALS
(2020)
Article
Engineering, Environmental
Xinping Zhang, Yuxin Guo, Xiaoyang Liu, Shun-Yu Wu, Ya-Xuan Zhu, Shao-Zhe Wang, Qiu-Yi Duan, Ke-Fei Xu, Zi-Heng Li, Xiao-Yu Zhu, Guang-Yu Pan, Fu-Gen Wu
Summary: This study develops a nanotrigger HCFT for simultaneous photodynamic therapy and light-triggered ferroptosis therapy. The nanotrigger can relieve tumor hypoxia, induce enhanced photodynamic reaction, and facilitate the continuation of Fenton reaction, ultimately leading to lethal ferroptosis in tumor cells.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Olumide Bolarinwa Ayodele, Toyin Daniel Shittu, Olayinka S. Togunwa, Dan Yu, Zhen-Yu Tian
Summary: This study focused on the semihydrogenation of acetylene in an ethylene-rich stream using two alloyed Pt catalysts PtCu and PtCo. The PtCu catalyst showed higher activity and ethylene yield compared to PtCo due to its higher unoccupied Pt d-orbital density. This indicates that alloying Pt with Cu is more promising for industrial relevant SHA catalyst.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Guowei Chen, Wen-Cheng Chen, Yaozu Su, Ruicheng Wang, Jia-Ming Jin, Hui Liang, Bingxue Tan, Dehua Hu, Shaomin Ji, Hao-Li Zhang, Yanping Huo, Yuguang Ma
Summary: This study proposes an intramolecular dual-locking design for organic luminescent materials, achieving high luminescence efficiency and performance for deep-blue organic light-emitting diodes. The material also exhibits unique mechanochromic luminescence behavior and strong fatigue resistance.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Joren van Stee, Gregory Hermans, Jinu Joseph John, Koen Binnemans, Tom Van Gerven
Summary: This work presents a continuous solvent extraction method for the separation of cobalt and nickel in a millifluidic system using Cyphos IL 101 (C101) as the extractant. The optimal conditions for extraction performance and solvent properties were determined by investigating the effects of channel length, flow rate, and temperature. The performance of a developed manifold structure was compared to a single-channel system, and excellent separation results were achieved. The continuous separation process using the manifold structure resulted in high purity cobalt and nickel products.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Yan Xu, Jingai Jiang, Xinyi Lv, Hui Li, Dongliang Yang, Wenjun Wang, Yanling Hu, Longcai Liu, Xiaochen Dong, Yu Cai
Summary: A programmed gas release nanoparticle was developed to address the challenges in treating diabetic infected wounds. It effectively removes drug-resistant pathogens and remodels the wound microenvironment using NO and H2S. The nanoparticle can eliminate bacteria and promote wound healing through antibacterial and anti-inflammatory effects.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Tong Xia, Zhilin Xi, Lianquan Suo, Chen Wang
Summary: This study investigated a highly efficient coal dust suppressant with low initial viscosity and high adhesion-solidification properties. The results demonstrated that the dust suppressant formed a network of multiple hydrogen bonding cross-linking and achieved effective adhesion and solidification of coal dust through various chemical reactions.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Jinzhi Cai, Zhenshan Li
Summary: A density functional theory-based rate equation was developed to predict the gas-solid reaction kinetics of CaO carbonation with CO2 in calcium looping. The negative activation energy of CaO carbonation close to equilibrium was accurately predicted through experimental validation.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Jianxiong Chen, Fuhao Ren, Ningning Yin, Jie Mao
Summary: This study presents an economically efficient and easily implementable surface modification approach to enhance the high-temperature electrical insulation and energy storage performance of polymer dielectrics. The self-assembly of high-insulation-performance boron nitride nanosheets (BNNS) on the film surface through electrostatic interactions effectively impedes charge injection from electrodes while promoting charge dissipation and heat transfer.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Zijian Li, Zhaohui Yang, Shao Wang, Hongxia Luo, Zhimin Xue, Zhenghui Liu, Tiancheng Mu
Summary: This study reports a strategy for upgrading polyester plastics into value-added chemicals using electrocatalytic methods. By inducing the targeted transfer of *OH species, polyethylene terephthalate was successfully upgraded into potassium diformate with high purity. This work not only develops an excellent electrocatalyst, but also provides guidance for the design of medium entropy metal oxides.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Navneet Singh Shekhawat, Surendra Kumar Patra, Ashok Kumar Patra, Bamaprasad Bag
Summary: This study primarily focuses on developing a sulphur dyeing process at room temperature using bacterial Lysate, which is environmentally friendly, energy and cost effective, and sustainable. The process shows promising improvements in dye uptake and fastness properties.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Dengjia Shen, Hongyang Ma, Madani Khan, Benjamin S. Hsiao
Summary: This study developed cationic PVC nanofibrous membranes with high filtration and adsorption capability for the removal of bacteria and hexavalent chromium ions from wastewater. The membranes demonstrated remarkable performance in terms of filtration efficiency and maximum adsorption capacity. Additionally, modified nanofibrous membranes were produced using recycled materials and showed excellent retention rates in dynamic adsorption processes.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Xiaoyan Wang, Zhikun Wang, Ben Jia, Chunling Li, Shuangqing Sun, Songqing Hu
Summary: Inspired by photosystem II, self-supported Fe-doped NiCoP nanowire arrays modified with carboxylate were constructed to boost industrial-level overall water splitting by employing the concerted proton-coupled electron transfer mechanism. The introduction of Fe and carboxyl ligand led to improved catalytic activity for HER and OER, and NCFCP@NF exhibited long-term durability for overall water splitting.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Pengyao Yu, Ge Yang, Yongming Chai, Lubomira Tosheva, Chunzheng Wang, Heqing Jiang, Chenguang Liu, Hailing Guo
Summary: Thin LTA zeolite membranes were prepared through secondary growth of nano LTA seeds in a highly reactive gel, resulting in membranes with superior permeability and selectivity in gas separation applications.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Baiqin Zhou, Huiping Li, Ziyu Wang, Hui Huang, Yujun Wang, Ruichun Yang, Ranran Huo, Xiaoyan Xu, Ting Zhou, Xiaochen Dong
Summary: The use of machine learning to predict the performance of specific adsorbents in phosphate adsorption shows great promise in saving time and revealing underlying mechanisms. However, the small size of the dataset and insufficient detailed information limits the model training process and the accuracy of results. To address this, the study employs a fuzzing strategy that replaces detailed numeric information with descriptive text messages on the physiochemical properties of adsorbents. This strategy allows the recovery of discarded samples with limited information, leading to accurate prediction of adsorption amount, capacity, and kinetics. The study also finds that phosphate uptake by adsorbents is generally through physisorption, with some involvement of chemisorption. The framework established in this study provides a practical approach for quickly predicting phosphate adsorption performance in urgent scenarios, using easily accessible information.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Paula Alejandra Lamprea Pineda, Joren Bruneel, Kristof Demeestere, Lisa Deraedt, Tex Goetschalckx, Herman Van Langenhove, Christophe Walgraeve
Summary: This study evaluates the use of four esterified fatty acids and three vegetable oils as absorption liquids for hydrophobic VOCs. The experimental results show that isopropyl myristate is the most efficient liquid for absorbing the target VOCs.
CHEMICAL ENGINEERING JOURNAL
(2024)
