Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene–environment interactions across the lifespan

Association between very to moderate preterm births, lung function deficits, and COPD at age 53 years: analysis of a prospective cohort study

(2022) Dinh S Bui et al.   Lancet Respiratory Medicine

Chronic obstructive pulmonary disease in never-smokers: risk factors, pathogenesis, and implications for prevention and treatment

(2022) Ian A Yang et al.   Lancet Respiratory Medicine

Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder

(2022) Michael H Cho et al.   Lancet Respiratory Medicine

DNA methylation perturbations may link altered development and aging in the lung

(2021) Priyadarshini Kachroo et al.   Aging-US

High eosinophil counts predict decline in FEV1: Results from the CanCOLD study

(2021) Wan C. Tan et al.   EUROPEAN RESPIRATORY JOURNAL

Genes, Environments, and Time: The Biology of Adversity and Resilience

(2021) W. Thomas Boyce et al.   PEDIATRICS

Pre-adolescence DNA methylation is associated with lung function trajectories from pre-adolescence to adulthood

(2021) Shadia Khan Sunny et al.   Clinical Epigenetics

Chromosome 17q12-21 Variants are Associated with Multiple Wheezing Phenotypes in Childhood

(2021) Brian Hallmark et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Transitioning from infancy to adulthood: a black box full of opportunities

(2021) Alvar Agusti et al.   EUROPEAN RESPIRATORY JOURNAL

Low birth weight as a potential risk factor for severe COVID-19 in adults

(2021) Fàtima Crispi et al.   Scientific Reports

The Relevance of a Physical Active Lifestyle and Physical Fitness on Immune Defense: Mitigating Disease Burden, With Focus on COVID-19 Consequences

(2021) Tayrine Ordonio Filgueira et al.   Frontiers in Immunology

Sex and Gender Omic Biomarkers in Men and Women With COPD

(2021) Dawn L. DeMeo   CHEST

Spirometry: A practical lifespan predictor of global health and chronic respiratory and non-respiratory diseases

(2021) Alvar Agusti et al.   European Journal of Internal Medicine

The coexistence of asthma and COPD: risk factors, clinical history and lung function trajectories

(2021) Alessandro Marcon et al.   EUROPEAN RESPIRATORY JOURNAL

Blood eosinophil counts and the development of obstructive lung disease: the Kangbuk Samsung Health Study

(2021) Hye Yun Park et al.   EUROPEAN RESPIRATORY JOURNAL

Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach

(2021) Simone Accordini et al.   EUROPEAN RESPIRATORY JOURNAL

Causal Effects of Body Mass Index on Airflow Obstruction and Forced Mid-Expiratory Flow: A Mendelian Randomization Study Taking Interactions and Age-Specific Instruments Into Consideration Toward a Life Course Perspective

(2021) Nicole Probst-Hensch et al.   Frontiers in Public Health

Dysanapsis and the Spirometric Response to Inhaled Bronchodilator

(2021) Motahareh Vameghestahbanati et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Treatment Trials in Young Patients with Chronic Obstructive Pulmonary Disease and Pre–Chronic Obstructive Pulmonary Disease Patients: Time to Move Forward

(2021) Fernando J. Martinez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The exposome and health: Where chemistry meets biology

(2020) Roel Vermeulen et al.   SCIENCE

Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome

(2020) Enrico Maiorino et al.   Nature Communications

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

(2020) Simon Kebede Merid et al.   Genome Medicine

Factors Associated with Low Lung Function in Different Age Bins in the General Population

(2020) Robab Breyer-Kohansal et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lung Function Trajectories Leading to Chronic Obstructive Pulmonary Disease as Predictors of Exacerbations and Mortality

(2020) Jacob Louis Marott et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

Asthma genetics revisited: understanding disease mechanisms by studying ethnically diverse groups

(2020) Erik Melén   Lancet Respiratory Medicine

On Genetics, Lung Developmental Biology and Adult Lung Function

(2020) Erik Melén et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD

(2020) Priyadarshini Kachroo et al.   EUROPEAN RESPIRATORY JOURNAL

Time for a change: anticipating the diagnosis and treatment of COPD

(2020) Alvar Agusti et al.   EUROPEAN RESPIRATORY JOURNAL

Association of Dysanapsis With Chronic Obstructive Pulmonary Disease Among Older Adults

(2020) Benjamin M. Smith et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts

(2020) Matthew Moll et al.   Lancet Respiratory Medicine

Endo-phenotyping of COPD patients

(2020) Peter J. Barnes   Expert Review of Respiratory Medicine

“Epigenetic clocks”: Theory and applications in human biology

(2020) Calen P. Ryan   AMERICAN JOURNAL OF HUMAN BIOLOGY

Lung DNA Methylation in COPD: Relationship with Smoking Status and Airflow Limitation Severity

(2020) Sandra Casas-Recasens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sex-specific associations with DNA methylation in lung tissue demonstrate smoking interactions

(2020) Hyeon-Kyoung Koo et al.   Epigenetics

Genes and environments, development and time

(2020) W. Thomas Boyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study

(2020) Stephen Milne et al.   THORAX

Early-life respiratory syncytial virus lower respiratory tract infection in a South African birth cohort: epidemiology and effect on lung health

(2020) Heather J Zar et al.   Lancet Global Health

Small airway loss in the physiologically ageing lung: a cross-sectional study in unused donor lungs

(2020) Stijn E Verleden et al.   Lancet Respiratory Medicine

From Gold 0 to Pre-COPD

(2020) MeiLan K Han et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Relationship between supernormal lung function and long-term risk of hospitalisations and mortality: a population-based cohort study

(2020) Yunus Çolak et al.   EUROPEAN RESPIRATORY JOURNAL

COPD-Associated miR-145-5p is Downregulated in Early Decline FEV1 Trajectories in Childhood Asthma

(2020) Anshul Tiwari et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD

(2020) John T. Benjamin et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of Parental Exposure on Offspring Health in Humans

(2020) Ali Jawaid et al.   TRENDS IN GENETICS

Preconception paternal alcohol exposure exerts sex-specific effects on offspring growth and long-term metabolic programming

(2019) Richard C. Chang et al.   Epigenetics & Chromatin

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

(2019) Nick Shrine et al.   NATURE GENETICS

Chronic Airway Diseases Early Stratification (CADSET): a new ERS Clinical Research Collaboration

(2019) Alvar Agusti et al.   EUROPEAN RESPIRATORY JOURNAL

Genomic interactions with exposure to inhaled pollutants

(2019) Stephanie J. London et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Linking COPD epidemiology with pediatric asthma care; implications for the patient and the physician

(2019) Erik Melén et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

(2019) Leanne K. Küpers et al.   Nature Communications

Lung function trajectories in health and disease

(2019) Alvar Agusti et al.   Lancet Respiratory Medicine

Expiratory airflow in late adolescence and early adulthood in individuals born very preterm or with very low birthweight compared with controls born at term or with normal birthweight: a meta-analysis of individual participant data

(2019) Lex W Doyle et al.   Lancet Respiratory Medicine

Adult Life-Course Trajectories of Lung Function and the Development of Emphysema: The CARDIA Lung Study

(2019) GR Washko et al.   AMERICAN JOURNAL OF MEDICINE

Genetic underpinnings of lung function and COPD

(2019) Astha Ranjan et al.   JOURNAL OF GENETICS

Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease

(2019) Alvar Agustí et al.   NEW ENGLAND JOURNAL OF MEDICINE

After asthma: redefining airways diseases

(2018) Ian D Pavord et al.   LANCET

The Key Role of Epigenetics in Human Disease Prevention and Mitigation

(2018) Andrew P. Feinberg   NEW ENGLAND JOURNAL OF MEDICINE

CC16 levels correlate with cigarette smoke exposure in bronchial epithelial cells and with lung function decline in smokers

(2018) David Chi-Leung Lam et al.   BMC Pulmonary Medicine

COPD beyond smoking: new paradigm, novel opportunities

(2018) Alvar Agustí et al.   Lancet Respiratory Medicine

Small airways disease in mild and moderate chronic obstructive pulmonary disease: a cross-sectional study

(2018) Hyun-Kyoung Koo et al.   Lancet Respiratory Medicine

Lung function trajectories from pre-school age to adulthood and their associations with early life factors: a retrospective analysis of three population-based birth cohort studies

(2018) Danielle C M Belgrave et al.   Lancet Respiratory Medicine

Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life

(2018) Dinh S Bui et al.   Lancet Respiratory Medicine

Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis

(2018) Saifon Chawanpaiboon et al.   Lancet Global Health

Epigenetic signatures of starting and stopping smoking

(2018) Daniel L. McCartney et al.   EBioMedicine

The LEAD (Lung, Heart, Social, Body) Study: Objectives, Methodology, and External Validity of the Population-Based Cohort Study

(2018) Robab Breyer-Kohansal et al.   JOURNAL OF EPIDEMIOLOGY

Premature birth affects the degree of airway dysanapsis and mechanical ventilatory constraints

(2017) Joseph W. Duke et al.   EXPERIMENTAL PHYSIOLOGY

Epigenetics and noncommunicable diseases

(2017) Gemma C Sharp et al.   Epigenomics

Lung function in early adulthood and health in later life: a transgenerational cohort analysis

(2017) Alvar Agustí et al.   Lancet Respiratory Medicine

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

(2016) Bonnie R. Joubert et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Network Analysis of Lung Transcriptomics Reveals a Distinct B-Cell Signature in Emphysema

(2016) Rosa Faner et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Presence of Chronic Mucus Hypersecretion across Adult Life in Relation to Chronic Obstructive Pulmonary Disease Development

(2016) James P. Allinson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

DNA methylation profiling in human lung tissue identifies genes associated with COPD

(2016) Jarrett D. Morrow et al.   Epigenetics

Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study

(2016) Natalie Terzikhan et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Early-Life Origins of Chronic Obstructive Pulmonary Disease

(2016) Fernando D. Martinez   NEW ENGLAND JOURNAL OF MEDICINE

Network analysis: a way forward for understanding COPD multimorbidity

(2015) Rosa Faner et al.   EUROPEAN RESPIRATORY JOURNAL

Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation

(2015) Florence Guida et al.   HUMAN MOLECULAR GENETICS

Current concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised management

(2015) Prescott G Woodruff et al.   LANCET

Drug development for airway diseases: looking forward

(2015) Stephen Holgate et al.   NATURE REVIEWS DRUG DISCOVERY

Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease

(2015) Peter Lange et al.   NEW ENGLAND JOURNAL OF MEDICINE

Developmental determinants in non-communicable chronic diseases and ageing

(2015) J Bousquet et al.   THORAX

Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study

(2015) Stefano Guerra et al.   Lancet Respiratory Medicine

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

(2015) Louise V Wain et al.   Lancet Respiratory Medicine

Network Analysis in the Investigation of Chronic Respiratory Diseases. From Basics to Application

(2014) Diego Diez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Blood Exposome and Its Role in Discovering Causes of Disease

(2014) Stephen M. Rappaport et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Vitamin C Supplementation for Pregnant Smoking Women and Pulmonary Function in Their Newborn Infants

(2014) Cindy T. McEvoy et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The exposome: a new paradigm to study the impact of environment on health

(2014) Martine Vrijheid   THORAX

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study

(2013) Shu-Yi Liao et al.   Environmental Health

Immune response in chronic obstructive pulmonary disease

(2013) Rosa Faner et al.   Expert Review of Clinical Immunology

Lessons from ECLIPSE: a review of COPD biomarkers

(2013) Rosa Faner et al.   THORAX

Abnormal Lung Aging in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

(2012) Rosa Faner et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epigenetic Influences That Modulate Infant Growth, Development, and Disease

(2012) Naveed Hussain   ANTIOXIDANTS & REDOX SIGNALING

Biomarkers intersect with the exposome

(2012) Stephen M. Rappaport   BIOMARKERS

The exposome: from concept to utility

(2012) Christopher Paul Wild   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Stephen S Lim et al.   LANCET

Pulmonary Fibrosis Induced by  -Herpesvirus in Aged Mice Is Associated With Increased Fibroblast Responsiveness to Transforming Growth Factor- 

(2011) P. N. Naik et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

(2011) John E. McDonough et al.   NEW ENGLAND JOURNAL OF MEDICINE

Changes in Forced Expiratory Volume in 1 Second over Time in COPD

(2011) Jørgen Vestbo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Addressing the Complexity of Chronic Obstructive Pulmonary Disease

(2010) Alvar Agusti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Maternal Vitamin A Supplementation and Lung Function in Offspring

(2010) William Checkley et al.   NEW ENGLAND JOURNAL OF MEDICINE

COPD in young patients: A pre-specified analysis of the four-year trial of tiotropium (UPLIFT)

(2010) A.H. Morice et al.   RESPIRATORY MEDICINE

Prediction of asthma in symptomatic preschool children using exhaled nitric oxide, Rint and specific IgE

(2010) D. Caudri et al.   THORAX

The Natural History of Chronic Airflow Obstruction Revisited

(2009) Robab Kohansal et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evidence for dysanapsis using computed tomographic imaging of the airways in older ex-smokers

(2009) A. William Sheel et al.   JOURNAL OF APPLIED PHYSIOLOGY

Chronic obstructive pulmonary disease in non-smokers

(2009) Sundeep S Salvi et al.   LANCET

A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease

(2008) Donald P. Tashkin et al.   NEW ENGLAND JOURNAL OF MEDICINE