Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress

Bupleurum chinense DC improves CUMS-induced depressive symptoms in rats through upregulation of the cAMP/PKA/CREB signalling pathway

(2022) Baijin Chang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Xiaoyaosan Alleviates Hippocampal Glutamate-Induced Toxicity in the CUMS Rats via NR2B and PI3K/Akt Signaling Pathway

(2021) Xue-Ming Zhou et al.   Frontiers in Pharmacology

Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation

(2020) Jing Su et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Saikosaponin d downregulates microRNA-155 and upregulates FGF2 to improve depression-like behaviors in rats induced by unpredictable chronic mild stress by negatively regulating NF-κB

(2020) Bin Chao et al.   BRAIN RESEARCH BULLETIN

Farnesoid X receptor-mediated cytoplasmic translocation of CRTC2 disrupts CREB-BDNF signaling in hippocampal CA1 and leads to the development of depression-like behaviors in mice

(2020) Wenfeng Hu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Traditional Chinese Medicine in Depression Treatment: From Molecules to Systems

(2020) Chan Li et al.   Frontiers in Pharmacology

Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression

(2019) Lixing Xu et al.   NEUROPHARMACOLOGY

Esketamine for Treatment-Resistant Depression — First FDA-Approved Antidepressant in a New Class

(2019) Jean Kim et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased Homer1-mGluR5 mediates chronic stress-induced depressive-like behaviors and glutamatergic dysregulation via activation of PERK-eIF2α

(2019) Ming-Xing Li et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Xiaoyaosan Ameliorates Chronic Immobilization Stress-Induced Depression-Like Behaviors and Anorexia in Rats: The Role of the Nesfatin-1–Oxytocin–Proopiomelanocortin Neural Pathway in the Hypothalamus

(2019) Qingyu Ma et al.   Frontiers in Psychiatry

mGlu receptors as potential targets for novel antidepressants

(2018) Shigeyuki Chaki et al.   CURRENT OPINION IN PHARMACOLOGY

Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway

(2018) Mauren K. Tavares et al.   NEUROCHEMISTRY INTERNATIONAL

A Homer 1 gene variant influences brain structure and function, lithium effects on white matter, and antidepressant response in bipolar disorder: A multimodal genetic imaging study

(2018) Francesco Benedetti et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Associations of Homer Scaffolding Protein 1 gene and psychological correlates with suicide attempts in Chinese: A pilot study of multifactorial risk model

(2018) Shitao Rao et al.   GENE

Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression

(2018) Qiqi Song et al.   Journal of Neuroinflammation

Aqueous Extract of Mori Folium Exerts Bone Protective Effect Through Regulation of Calcium and Redox Homeostasis via PTH/VDR/CaBP and AGEs/RAGE/Nox4/NF-κB Signaling in Diabetic Rats

(2018) Chenyue Liu et al.   Frontiers in Pharmacology

Targeting glutamate signalling in depression: progress and prospects

(2017) James W. Murrough et al.   NATURE REVIEWS DRUG DISCOVERY

Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis

(2017) Hong-Yan Li et al.   PSYCHOPHARMACOLOGY

Depression-Related Increases and Decreases in Appetite: Dissociable Patterns of Aberrant Activity in Reward and Interoceptive Neurocircuitry

(2016) W. Kyle Simmons et al.   AMERICAN JOURNAL OF PSYCHIATRY

New perspectives on the involvement of mTOR in depression as well as in the action of antidepressant drugs

(2016) Zuleide M. Ignácio et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Kai-Xin-San, a standardized traditional Chinese medicine formula, up-regulates the expressions of synaptic proteins on hippocampus of chronic mild stress induced depressive rats and primary cultured rat hippocampal neuron

(2016) Yue Zhu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Potential roles for Homer1 and Spinophilin in the preventive effect of electroconvulsive seizures on stress-induced CA3c dendritic retraction in the hippocampus

(2015) Heidi Kaastrup Müller et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Glutamate Stimulates Local Protein Synthesis in the Axons of Rat Cortical Neurons by Activating α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors and Metabotropic Glutamate Receptors

(2015) Wei-Lun Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC2/Rictor Signaling Disrupts Dopamine-Dependent Behaviors via Defects in Striatal Dopamine Neurotransmission

(2015) O. I. Dadalko et al.   JOURNAL OF NEUROSCIENCE

Alteration by p11 of mGluR5 localization regulates depression-like behaviors

(2015) K-W Lee et al.   MOLECULAR PSYCHIATRY

Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a

(2015) Tsvetan Serchov et al.   NEURON

mTOR in Brain Physiology and Pathologies

(2015) Joël Bockaert et al.   PHYSIOLOGICAL REVIEWS

Nimodipine Activates TrkB Neurotrophin Receptors and Induces Neuroplastic and Neuroprotective Signaling Events in the Mouse Hippocampus and Prefrontal Cortex

(2014) Janne Koskimäki et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Homer1/mGluR5 Activity Moderates Vulnerability to Chronic Social Stress

(2014) Klaus V Wagner et al.   NEUROPSYCHOPHARMACOLOGY

Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling

(2014) Peng Zhong et al.   NEUROPSYCHOPHARMACOLOGY

Neuroprotective effects of Total Saikosaponins of Bupleurum yinchowense on corticosterone-induced apoptosis in PC12 cells

(2013) Zong-Yang Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Bacterial Cytolysin during Meningitis Disrupts the Regulation of Glutamate in the Brain, Leading to Synaptic Damage

(2013) Carolin Wippel et al.   PLoS Pathogens

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Targeting the Glutamatergic System to Treat Major Depressive Disorder

(2012) Daniel C. Mathews et al.   DRUGS

Calcium-Dependent Networks in Dopamine–Glutamate Interaction: The Role of Postsynaptic Scaffolding Proteins

(2012) Andrea de Bartolomeis et al.   MOLECULAR NEUROBIOLOGY

mGlu2/3 and mGlu5 receptors: Potential targets for novel antidepressants

(2012) Shigeyuki Chaki et al.   NEUROPHARMACOLOGY

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

(2012) R. S. Duman et al.   SCIENCE

Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [11C]ABP688 PET and Postmortem Study

(2011) Alexandra Deschwanden et al.   AMERICAN JOURNAL OF PSYCHIATRY

mTOR signaling in disease

(2011) Eva Dazert et al.   CURRENT OPINION IN CELL BIOLOGY

Meta-analysis of the clinical effectiveness of traditional Chinese medicine formula Chaihu-Shugan-San in depression

(2011) Yang Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

(2011) Maurizio Popoli et al.   NATURE REVIEWS NEUROSCIENCE

Signaling pathways underlying the rapid antidepressant actions of ketamine

(2011) Ronald S. Duman et al.   NEUROPHARMACOLOGY

CA1 neurons in the human hippocampus are critical for autobiographical memory, mental time travel, and autonoetic consciousness

(2011) T. Bartsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Association-, Replication-, and Neuroimaging Study Implicates HOMER1 in the Etiology of Major Depression

(2010) Marcella Rietschel et al.   BIOLOGICAL PSYCHIATRY

Metabotropic Glutamate Receptor 5/Homer Interactions Underlie Stress Effects on Fear

(2010) Natalie C. Tronson et al.   BIOLOGICAL PSYCHIATRY

Premorbid sleep, appetite, energy, and cognitive circadian profile in patients with depressive disorders

(2010) G. Bersani et al.   EUROPEAN PSYCHIATRY

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

A Genomewide Association Study Points to Multiple Loci That Predict Antidepressant Drug Treatment Outcome in Depression

(2009) Marcus Ising et al.   ARCHIVES OF GENERAL PSYCHIATRY