4.7 Article

Meta-analysis of the clinical effectiveness of traditional Chinese medicine formula Chaihu-Shugan-San in depression

Journal

JOURNAL OF ETHNOPHARMACOLOGY
Volume 141, Issue 2, Pages 571-577

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2011.08.079

Keywords

Chaihu-Shugan-San; Depression; Meta-analysis; Clinical effectiveness

Funding

  1. Natural Science Foundation of China [81072967]
  2. SATCM

Ask authors/readers for more resources

Aim of study: Depression is a psychiatric disorder. Chaihu-Shugan-San (CSS) is a traditional Chinese medicine formula suggested in the treatment of depression, but its effectiveness and safety are not well defined. This meta-analysis aimed to assess the effectiveness and safety of CSS in depression therapy. Materials and methods: The databases including MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, CNKI database, Wanfang Data and VIP Information were searched. Papers were reviewed systematically by two researchers and were analyzed using Cochrane software Revman 5.0. Results: Ten randomized controlled trials comparing 835 subjects were included. Of these studies, seven studies used fluoxetine (20 mg, once a day), two used paroxetine (20 mg, once a day) and one used doxepin (25 mg, two times a day) as the antidepressant drugs. Meta-analyses revealed that CSS in combination with antidepressant drugs treatment significantly improved depressive symptoms (WMD = -3.56; 95% Cl -5.09 to -2.03) and significantly increased effective rate (OR = 3.31; 95% Cl 1.80-6.10) and recovery rate (OR = 2.32; 95% Cl 1.61-3.34) compared with antidepressant drugs therapy. In addition, the efficacy of CSS as monotherapy was significantly better than antidepressants in improving depressive symptoms (WMD = -3.09; 95% CI -5.13 to -1.06) and in creasing effective rate (OR = 2.61; 95% CI 1.23-5.53). csS was comparable to antidepressants in increasing recovery rate (OR= 1.83; 95% Cl 0.84-3.98). No serious adverse events were reported in any of the included trials. Conclusion: The present work supported that CSS was effective and safe in treating depressed patients. More full-scale randomized clinical trials with reliable designs are recommended to further evaluate the clinical benefit and long-term effectiveness of CSS for the treatment of depression. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available