Targeting glutamate signalling in depression: progress and prospects
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting glutamate signalling in depression: progress and prospects
Authors
Keywords
-
Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 16, Issue 7, Pages 472-486
Publisher
Springer Nature
Online
2017-03-17
DOI
10.1038/nrd.2017.16
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Change in cytokine levels is not associated with rapid antidepressant response to ketamine in treatment-resistant depression
- (2017) Minkyung Park et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Placebo-controlled pilot trial testing dose titration and intravenous, intramuscular and subcutaneous routes for ketamine in depression
- (2016) C. K. Loo et al. ACTA PSYCHIATRICA SCANDINAVICA
- A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression
- (2016) Jaskaran B. Singh et al. AMERICAN JOURNAL OF PSYCHIATRY
- Ketamine augmentation for outpatients with treatment-resistant depression: Preliminary evidence for two-step intravenous dose escalation
- (2016) Cristina Cusin et al. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
- Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study
- (2016) Jaskaran B. Singh et al. BIOLOGICAL PSYCHIATRY
- Ketamine-induced inhibition of glycogen synthase kinase-3 contributes to the augmentation of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor signaling
- (2016) Eléonore Beurel et al. BIPOLAR DISORDERS
- Oral ketamine for the treatment of pain and treatment-resistant depression
- (2016) Robert A. Schoevers et al. BRITISH JOURNAL OF PSYCHIATRY
- NMDA antagonist treatment of depression
- (2016) Nolan R Williams et al. CURRENT OPINION IN NEUROBIOLOGY
- Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate
- (2016) Darragh Downey et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder
- (2016) James W. Murrough et al. HUMAN BRAIN MAPPING
- Ketamine administration reduces amygdalo-hippocampal reactivity to emotional stimulation
- (2016) Milan Scheidegger et al. HUMAN BRAIN MAPPING
- An assessment of the anti-fatigue effects of ketamine from a double-blind, placebo-controlled, crossover study in bipolar disorder
- (2016) Leorey N. Saligan et al. JOURNAL OF AFFECTIVE DISORDERS
- A New Perspective on the Anti-Suicide Effects With Ketamine Treatment
- (2016) Yena Lee et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects
- (2016) G M I Chowdhury et al. MOLECULAR PSYCHIATRY
- NMDAR inhibition-independent antidepressant actions of ketamine metabolites
- (2016) Panos Zanos et al. NATURE
- Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
- (2016) Ronald S Duman et al. NATURE MEDICINE
- Deuterated drugs draw heavier backing
- (2016) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Efficacy and Safety of Basimglurant as Adjunctive Therapy for Major Depression
- (2016) Jorge A. Quiroz et al. JAMA Psychiatry
- ABCB1gene variants and antidepressant treatment outcome: A meta-analysis
- (2015) Barbara Breitenstein et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression
- (2015) D. Jeffrey Newport et al. AMERICAN JOURNAL OF PSYCHIATRY
- Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics
- (2015) Chadi G. Abdallah et al. Annual Review of Medicine
- Serum Interleukin-6 Is a Predictive Biomarker for Ketamine’s Antidepressant Effect in Treatment-Resistant Patients With Major Depression
- (2015) Jian-jun Yang et al. BIOLOGICAL PSYCHIATRY
- Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cortex
- (2015) Laura Jiménez-Sánchez et al. CEREBRAL CORTEX
- COGNITION-CHILDHOOD MALTREATMENT INTERACTIONS IN THE PREDICTION OF ANTIDEPRESSANT OUTCOMES IN MAJOR DEPRESSIVE DISORDER PATIENTS: RESULTS FROM THE iSPOT-D TRIAL
- (2015) Shefali Miller et al. DEPRESSION AND ANXIETY
- Single-Dose Ketamine Followed by Daily d-Cycloserine in Treatment-Resistant Bipolar Depression
- (2015) Joshua T. Kantrowitz et al. JOURNAL OF CLINICAL PSYCHIATRY
- Randomized Proof of Concept Trial of GLYX-13, an N-Methyl-D-Aspartate Receptor Glycine Site Partial Agonist, in Major Depressive Disorder Nonresponsive to a Previous Antidepressant Agent
- (2015) SHELDON PRESKORN et al. Journal of Psychiatric Practice
- Neural correlates of change in major depressive disorder anhedonia following open-label ketamine
- (2015) Níall Lally et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Sex differences in glutamate receptor gene expression in major depression and suicide
- (2015) A L Gray et al. MOLECULAR PSYCHIATRY
- A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder
- (2015) M S Milak et al. MOLECULAR PSYCHIATRY
- Towards new mechanisms: an update on therapeutics for treatment-resistant major depressive disorder
- (2015) G I Papakostas et al. MOLECULAR PSYCHIATRY
- The Genetics of Stress-Related Disorders: PTSD, Depression and Anxiety Disorders
- (2015) Jordan W Smoller NEUROPSYCHOPHARMACOLOGY
- Amygdala Reactivity to Emotional Faces in the Prediction of General and Medication-Specific Responses to Antidepressant Treatment in the Randomized iSPOT-D Trial
- (2015) Leanne M Williams et al. NEUROPSYCHOPHARMACOLOGY
- Altered thalamocortical rhythmicity and connectivity in mice lacking CaV3.1 T-type Ca2+channels in unconsciousness
- (2015) Soonwook Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Single i.v. ketamine augmentation of newly initiated escitalopram for major depression: results from a randomized, placebo-controlled 4-week study
- (2015) Y.-D. Hu et al. PSYCHOLOGICAL MEDICINE
- Ketamine for rapid reduction of suicidal ideation: a randomized controlled trial
- (2015) J. W. Murrough et al. PSYCHOLOGICAL MEDICINE
- Large-Scale Network Dysfunction in Major Depressive Disorder
- (2015) Roselinde H. Kaiser et al. JAMA Psychiatry
- R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects
- (2015) C Yang et al. Translational Psychiatry
- Regulation of neural responses to emotion perception by ketamine in individuals with treatment-resistant major depressive disorder
- (2015) J W Murrough et al. Translational Psychiatry
- Glutamate Metabolism in Major Depressive Disorder
- (2014) Chadi G. Abdallah et al. AMERICAN JOURNAL OF PSYCHIATRY
- A Randomized Controlled Trial of Intranasal Ketamine in Major Depressive Disorder
- (2014) Kyle A.B. Lapidus et al. BIOLOGICAL PSYCHIATRY
- Effects of Striatal ΔFosB Overexpression and Ketamine on Social Defeat Stress–Induced Anhedonia in Mice
- (2014) Rachel J. Donahue et al. BIOLOGICAL PSYCHIATRY
- Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States
- (2014) Katharina L. Dürr et al. CELL
- EFFECTS OF KETAMINE ON EXPLICIT AND IMPLICIT SUICIDAL COGNITION: A RANDOMIZED CONTROLLED TRIAL IN TREATMENT-RESISTANT DEPRESSION
- (2014) Rebecca B. Price et al. DEPRESSION AND ANXIETY
- Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression
- (2014) Michelle J. Chandley et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Neurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression
- (2014) Paulo R. Shiroma et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Do the dissociative side effects of ketamine mediate its antidepressant effects?
- (2014) David A. Luckenbaugh et al. JOURNAL OF AFFECTIVE DISORDERS
- Ketamine Safety and Tolerability in Clinical Trials for Treatment-Resistant Depression
- (2014) Le-Ben Wan et al. JOURNAL OF CLINICAL PSYCHIATRY
- A Targeted Multiplexed Proteomic Investigation Identifies Ketamine-Induced Changes in Immune Markers in Rat Serum and Expression Changes in Protein Kinases/Phosphatases in Rat Brain
- (2014) Hendrik Wesseling et al. JOURNAL OF PROTEOME RESEARCH
- Improvement in suicidal ideation after ketamine infusion: Relationship to reductions in depression and anxiety
- (2014) Elizabeth D. Ballard et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Neurocognitive Effects of Ketamine and Association with Antidepressant Response in Individuals with Treatment-Resistant Depression: A Randomized Controlled Trial
- (2014) James W Murrough et al. NEUROPSYCHOPHARMACOLOGY
- Organization, control and function of extrasynaptic NMDA receptors
- (2014) T. Papouin et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses
- (2014) E. S. Gideons et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Review of the Clinical, Economic, and Societal Burden of Treatment-Resistant Depression: 1996–2013
- (2014) David A. Mrazek et al. PSYCHIATRIC SERVICES
- A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes
- (2014) A. McGirr et al. PSYCHOLOGICAL MEDICINE
- Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression
- (2014) N Lally et al. Translational Psychiatry
- Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial
- (2013) James W. Murrough et al. AMERICAN JOURNAL OF PSYCHIATRY
- Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses
- (2013) Bhavya Voleti et al. BIOLOGICAL PSYCHIATRY
- Inhibition of Glycine Transporter-I as a Novel Mechanism for the Treatment of Depression
- (2013) Chih-Chia Huang et al. BIOLOGICAL PSYCHIATRY
- Glycine Transporter-I Inhibitors: A New Class of Antidepressant?
- (2013) Sanjay J. Mathew BIOLOGICAL PSYCHIATRY
- Neural Correlates of Rapid Antidepressant Response to Ketamine in Treatment-Resistant Unipolar Depression: A Preliminary Positron Emission Tomography Study
- (2013) Paul J. Carlson et al. BIOLOGICAL PSYCHIATRY
- From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders
- (2013) Gerard Sanacora et al. BIOLOGICAL PSYCHIATRY
- Neural correlates of rapid antidepressant response to ketamine in bipolar disorder
- (2013) Allison C Nugent et al. BIPOLAR DISORDERS
- PREDICTIVE SOCIOECONOMIC AND CLINICAL PROFILES OF ANTIDEPRESSANT RESPONSE AND REMISSION
- (2013) Felipe A. Jain et al. DEPRESSION AND ANXIETY
- Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression
- (2013) C. N. Haile et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Augmentation of response and remission to serial intravenous subanesthetic ketamine in treatment resistant depression
- (2013) Paulo R. Shiroma et al. JOURNAL OF AFFECTIVE DISORDERS
- Repeated S-ketamine Infusions in Therapy Resistant Depression: A Case Series
- (2013) Felix Segmiller et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Serial infusions of low-dose ketamine for major depression
- (2013) Keith G Rasmussen et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010
- (2013) Harvey A Whiteford et al. LANCET
- Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects
- (2013) G Sanacora et al. MOLECULAR PSYCHIATRY
- GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects
- (2013) Jeffrey Burgdorf et al. NEUROPSYCHOPHARMACOLOGY
- Conceptual Confluence: The Kynurenine Pathway as a Common Target for Ketamine and the Convergence of the Inflammation and Glutamate Hypotheses of Depression
- (2013) Andrew H Miller NEUROPSYCHOPHARMACOLOGY
- GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine
- (2013) Rong-Jian Liu et al. NEUROPSYCHOPHARMACOLOGY
- R (−)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine
- (2013) Ji-chun Zhang et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Neurocognitive effects of ketamine in treatment-resistant major depression: association with antidepressant response
- (2013) James W. Murrough et al. PSYCHOPHARMACOLOGY
- Maximum Tolerated Dose Evaluation of the AMPA Modulator Org 26576 in Healthy Volunteers and Depressed Patients
- (2013) Kari R. Nations et al. Drugs in research & development
- Does Intraoperative Ketamine Attenuate Inflammatory Reactivity Following Surgery? A Systematic Review and Meta-Analysis
- (2012) Ola Dale et al. ANESTHESIA AND ANALGESIA
- Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Antidepressant Efficacy of Ketamine in Depressed Patients
- (2012) Gonzalo Laje et al. BIOLOGICAL PSYCHIATRY
- Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial
- (2012) Carlos A. Zarate et al. BIOLOGICAL PSYCHIATRY
- A Randomized Trial of a Low-Trapping Nonselective N-Methyl-D-Aspartate Channel Blocker in Major Depression
- (2012) Carlos A. Zarate et al. BIOLOGICAL PSYCHIATRY
- Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression
- (2012) James W. Murrough et al. BIOLOGICAL PSYCHIATRY
- Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder
- (2012) Wallace C. Duncan et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- A randomized add-on trial of high-dose d-cycloserine for treatment-resistant depression
- (2012) Uriel Heresco-Levy et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- A Randomized, Placebo-Controlled, Crossover Pilot Trial of the Oral Selective NR2B Antagonist MK-0657 in Patients With Treatment-Resistant Major Depressive Disorder
- (2012) Lobna Ibrahim et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial
- (2012) Kari R Nations et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology
- (2012) J M Stone et al. MOLECULAR PSYCHIATRY
- Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression
- (2012) Z.A. Hughes et al. NEUROPHARMACOLOGY
- Chronic Ketamine Administration Modulates Midbrain Dopamine System in Mice
- (2012) Sijie Tan et al. PLoS One
- Synaptic Dysfunction in Depression: Potential Therapeutic Targets
- (2012) R. S. Duman et al. SCIENCE
- Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [11C]ABP688 PET and Postmortem Study
- (2011) Alexandra Deschwanden et al. AMERICAN JOURNAL OF PSYCHIATRY
- Too Many Cooks? Intrinsic and Synaptic Homeostatic Mechanisms in Cortical Circuit Refinement
- (2011) Gina Turrigiano Annual Review of Neuroscience
- Structural Neuroimaging Studies in Major Depressive Disorder
- (2011) Matthew J. Kempton ARCHIVES OF GENERAL PSYCHIATRY
- Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice
- (2011) E Beurel et al. MOLECULAR PSYCHIATRY
- Grand challenges in global mental health
- (2011) Pamela Y. Collins et al. NATURE
- NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
- (2011) Anita E. Autry et al. NATURE
- A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression
- (2010) Nancy Diazgranados et al. ARCHIVES OF GENERAL PSYCHIATRY
- Magnetic Resonance Spectroscopy Studies of Glutamate-Related Abnormalities in Mood Disorders
- (2010) Cagri Yüksel et al. BIOLOGICAL PSYCHIATRY
- Challenges for and current status of research into positive modulators of AMPA receptors
- (2010) Simon E Ward et al. BRITISH JOURNAL OF PHARMACOLOGY
- Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos
- (2010) Junbo Liu et al. NATURE CELL BIOLOGY
- Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
- (2010) Giles E. Hardingham et al. NATURE REVIEWS NEUROSCIENCE
- mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
- (2010) N. Li et al. SCIENCE
- Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression
- (2009) Rebecca B. Price et al. BIOLOGICAL PSYCHIATRY
- Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression
- (2009) Marije aan het Rot et al. BIOLOGICAL PSYCHIATRY
- Brain-Derived Neurotrophic Factor and Initial Antidepressant Response to anN-Methyl-D-Aspartate Antagonist
- (2009) Rodrigo Machado-Vieira et al. JOURNAL OF CLINICAL PSYCHIATRY
- Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity
- (2009) R. I. Stanika et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glutamate-based antidepressants: 20 years on
- (2009) Phil Skolnick et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Glutamate and the Neural Basis of the Subjective Effects of Ketamine
- (2008) J. F. William Deakin et al. ARCHIVES OF GENERAL PSYCHIATRY
- Elevated levels of NR2A and PSD-95 in the lateral amygdala in depression
- (2008) Beata Karolewicz et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder
- (2008) Sheldon H. Preskorn et al. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
- Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole
- (2008) M Banasr et al. MOLECULAR PSYCHIATRY
- The molecular neurobiology of depression
- (2008) Vaishnav Krishnan et al. NATURE
- Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
- (2008) Gerard Sanacora et al. NATURE REVIEWS DRUG DISCOVERY
- A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral–CA1 synapses in hippocampus
- (2008) Xiao-lei Zhang et al. NEUROPHARMACOLOGY
- Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression
- (2008) Anteneh M. Feyissa et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors
- (2007) Sungho Maeng et al. BIOLOGICAL PSYCHIATRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation