mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice

HIV mRNA Vaccines—Progress and Future Paths

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Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

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Immunogenicity of stabilized HIV-1 Env trimers delivered by self-amplifying mRNA

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Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

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Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

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A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques

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Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

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Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

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Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

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COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

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B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

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Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

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SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation

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Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers

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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

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eCD4-Ig limits HIV-1 escape more effectively than CD4-Ig or a broadly neutralizing antibody

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A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA

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Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles

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A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses

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Multiple roles for HIV broadly neutralizing antibodies

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Targeted selection of HIV-specific antibody mutations by engineering B cell maturation

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Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development

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Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer

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Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

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Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

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The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen

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Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

(2018) Norbert Pardi et al.   Nature Communications

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

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Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth

(2018) Kshitij Wagh et al.   Cell Reports

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure

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The HIV-1 envelope glycoprotein structure: nailing down a moving target

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Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem

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Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

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Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529

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Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies

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Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models

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Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages

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Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

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Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

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Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

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Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site

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Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

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Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

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Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers

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Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

(2015) Young Do Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

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Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

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Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies

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Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection

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Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

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Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

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Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

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Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

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Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

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Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

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Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

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A Short Segment of the HIV-1 gp120 V1/V2 Region Is a Major Determinant of Resistance to V1/V2 Neutralizing Antibodies

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B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

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Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation

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