Targeted selection of HIV-specific antibody mutations by engineering B cell maturation
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Title
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation
Authors
Keywords
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Journal
SCIENCE
Volume 366, Issue 6470, Pages eaay7199
Publisher
American Association for the Advancement of Science (AAAS)
Online
2019-12-06
DOI
10.1126/science.aay7199
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Note: Only part of the references are listed.- Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies
- (2019) Rory Henderson et al. Nature Communications
- Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance
- (2019) Kimberly M. Cirelli et al. CELL
- Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques
- (2019) Amelia Escolano et al. NATURE
- Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies
- (2019) Celia C. LaBranche et al. PLoS Pathogens
- Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development
- (2018) Kevin Wiehe et al. Cell Host & Microbe
- Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens
- (2018) Robert K. Abbott et al. IMMUNITY
- Cancer immunotherapy using checkpoint blockade
- (2018) Antoni Ribas et al. SCIENCE
- HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope
- (2018) Daniela Fera et al. Nature Communications
- Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen
- (2018) Weston B. Struwe et al. Cell Reports
- Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design
- (2018) Chaim A. Schramm et al. Frontiers in Immunology
- Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier
- (2018) Mattia Bonsignori et al. IMMUNITY
- Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers
- (2018) Talar Tokatlian et al. SCIENCE
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach
- (2017) Paola Martinez-Murillo et al. IMMUNITY
- Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches
- (2017) Matthias Pauthner et al. IMMUNITY
- The quest for an antibody-based HIV vaccine
- (2017) Barton F. Haynes et al. IMMUNOLOGICAL REVIEWS
- Glycosylation Benchmark Profile for HIV-1 Envelope Glycoprotein Production Based on Eleven Env Trimers
- (2017) Eden P. Go et al. JOURNAL OF VIROLOGY
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies
- (2017) Joyce K. Hwang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Developing an HIV vaccine
- (2017) Barton F. Haynes et al. SCIENCE
- Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide
- (2017) S. Munir Alam et al. Science Translational Medicine
- Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies
- (2017) Mattia Bonsignori et al. Science Translational Medicine
- Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers
- (2017) Charles D. Morris et al. mBio
- Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations
- (2017) Wilton B. Williams et al. Nature Communications
- Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization
- (2017) Alba Torrents de la Peña et al. Cell Reports
- Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates
- (2017) Kevin O. Saunders et al. Cell Reports
- Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models
- (2017) Kevin O. Saunders et al. Cell Reports
- A Formulated TLR7/8 Agonist is a Flexible, Highly Potent and Effective Adjuvant for Pandemic Influenza Vaccines
- (2017) Neal Van Hoeven et al. Scientific Reports
- Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody
- (2016) Mattia Bonsignori et al. CELL
- Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice
- (2016) Amelia Escolano et al. CELL
- Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires
- (2016) Ming Tian et al. CELL
- HIV-Host Interactions: Implications for Vaccine Design
- (2016) Barton F. Haynes et al. Cell Host & Microbe
- Men and mice: Relating their ages
- (2016) Sulagna Dutta et al. LIFE SCIENCES
- In vitro reconstitution of B cell receptor–antigen interactions to evaluate potential vaccine candidates
- (2016) Grant C Weaver et al. Nature Protocols
- Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages
- (2016) Ruijun Zhang et al. Science Translational Medicine
- Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles
- (2016) Linling He et al. Nature Communications
- High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells
- (2016) Jidnyasa Ingale et al. Cell Reports
- Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection
- (2016) Zizhang Sheng et al. PLoS Computational Biology
- Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes
- (2015) Steven W. de Taeye et al. CELL
- Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection
- (2015) Xueling Wu et al. CELL
- CTFFIND4: Fast and accurate defocus estimation from electron micrographs
- (2015) Alexis Rohou et al. JOURNAL OF STRUCTURAL BIOLOGY
- Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost
- (2015) Sandrine L. Hulot et al. JOURNAL OF VIROLOGY
- Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140
- (2015) Eden P. Go et al. JOURNAL OF VIROLOGY
- Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement
- (2015) Frank DiMaio et al. NATURE METHODS
- EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy
- (2015) Benjamin A Barad et al. NATURE METHODS
- Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
- (2015) Young Do Kwon et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity
- (2015) Kwinten Sliepen et al. Retrovirology
- Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
- (2015) Young Do Kwon et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6
- (2015) Timothy Grant et al. eLife
- Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies
- (2014) Feng Gao et al. CELL
- Glycosylation and Disulfide Bond Analysis of Transiently and Stably Expressed Clade C HIV-1 gp140 Trimers in 293T Cells Identifies Disulfide Heterogeneity Present in Both Proteins and Differences in O-Linked Glycosylation
- (2014) Eden P. Go et al. JOURNAL OF PROTEOME RESEARCH
- Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation
- (2014) Thomas B. Kepler et al. Frontiers in Immunology
- Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization
- (2013) Florian Klein et al. CELL
- Immune Tolerance Negatively Regulates B Cells in Knock-In Mice Expressing Broadly Neutralizing HIV Antibody 4E10
- (2013) C. Doyle-Cooper et al. JOURNAL OF IMMUNOLOGY
- Common Tolerance Mechanisms, but Distinct Cross-Reactivities Associated with gp41 and Lipids, Limit Production of HIV-1 Broad Neutralizing Antibodies 2F5 and 4E10
- (2013) Y. Chen et al. JOURNAL OF IMMUNOLOGY
- Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies
- (2013) Masaru Kanekiyo et al. NATURE
- Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
- (2013) Hua-Xin Liao et al. NATURE
- Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
- (2013) Leopold Kong et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Models of Somatic Hypermutation Targeting and Substitution Based on Synonymous Mutations from High-Throughput Immunoglobulin Sequencing Data
- (2013) Gur Yaari et al. Frontiers in Immunology
- B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study
- (2012) Barton F Haynes et al. NATURE BIOTECHNOLOGY
- Prevention of overfitting in cryo-EM structure determination
- (2012) Sjors H W Scheres et al. NATURE METHODS
- FLASH: fast length adjustment of short reads to improve genome assemblies
- (2011) T. Magoc et al. BIOINFORMATICS
- Sequential Immunization with a Subtype B HIV-1 Envelope Quasispecies Partially Mimics the In Vivo Development of Neutralizing Antibodies
- (2011) D. C. Malherbe et al. JOURNAL OF VIROLOGY
- Broad neutralization coverage of HIV by multiple highly potent antibodies
- (2011) Laura M. Walker et al. NATURE
- Analysis of the Disulfide Bond Arrangement of the HIV-1 Envelope Protein CON-S gp140 ΔCFI Shows Variability in the V1 and V2 Regions
- (2010) Eden P. Go et al. JOURNAL OF PROTEOME RESEARCH
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Glycosylation Site-Specific Analysis of Clade C HIV-1 Envelope Proteins
- (2009) Eden P. Go et al. JOURNAL OF PROTEOME RESEARCH
- High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies
- (2009) Hua-Xin Liao et al. JOURNAL OF VIROLOGICAL METHODS
- Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance
- (2009) L. Verkoczy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glycosylation Site-Specific Analysis of HIV Envelope Proteins (JR-FL and CON-S) Reveals Major Differences in Glycosylation Site Occupancy, Glycoform Profiles, and Antigenic Epitopesʼ Accessibility
- (2008) Eden P. Go et al. JOURNAL OF PROTEOME RESEARCH
- Comparison of HPLC/ESI-FTICR MS versus MALDI-TOF/TOF MS for glycopeptide analysis of a highly glycosylated HIV envelope glycoprotein
- (2008) Janet Irungu et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
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