Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

HCMV glycoprotein B nucleoside-modified mRNA vaccine elicits antibody responses with greater durability and breadth than MF59-adjuvanted gB protein immunization

(2020) Cody S. Nelson et al.   JOURNAL OF VIROLOGY

Landscapes of binding antibody and T-cell responses to pox-protein HIV vaccines in Thais and South Africans

(2020) Lue Ping Zhao et al.   PLoS One

Another HIV vaccine strategy fails in large-scale study

(2020) Jon Cohen   SCIENCE

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

(2020) Rory Henderson et al.   Nature Communications

Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19

(2020) Gregory D. Sempowski et al.   CELL

Army Liposome Formulation (ALF) family of vaccine adjuvants

(2020) Carl R. Alving et al.   Expert Review of Vaccines

A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice

(2020) Alec W. Freyn et al.   MOLECULAR THERAPY

The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation

(2020) Jieliang Wang et al.   AAPS PHARMSCITECH

Recent advances in mRNA vaccine technology

(2020) Norbert Pardi et al.   CURRENT OPINION IN IMMUNOLOGY

A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

(2020) Dorottya Laczkó et al.   IMMUNITY

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

(2020) Mark J. Mulligan et al.   NATURE

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

(2020) Cheryl Keech et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of HIV-1 nucleoside-modified mRNA vaccines in rabbits and rhesus macaques

(2019) Norbert Pardi et al.   Molecular Therapy-Nucleic Acids

Protein and Glycan Mimicry in HIV Vaccine Design

(2019) Gemma E. Seabright et al.   JOURNAL OF MOLECULAR BIOLOGY

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

(2019) Celia C. LaBranche et al.   PLoS Pathogens

Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes

(2019) Sita Awasthi et al.   Science Immunology

Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein Against Lethal Nipah virus Challenge in Syrian Hamsters

(2019) Michael K Lo et al.   JOURNAL OF INFECTIOUS DISEASES

Multiple roles for HIV broadly neutralizing antibodies

(2019) Barton F. Haynes et al.   Science Translational Medicine

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

Targeted selection of HIV-specific antibody mutations by engineering B cell maturation

(2019) Kevin O. Saunders et al.   SCIENCE

A phase 1 antigen dose escalation trial to evaluate safety, tolerability and immunogenicity of the leprosy vaccine candidate LepVax (LEP-F1 + GLA–SE) in healthy adults

(2019) Malcolm S. Duthie et al.   VACCINE

Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development

(2018) Kevin Wiehe et al.   Cell Host & Microbe

Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer

(2018) Peng Zhang et al.   Cell Host & Microbe

HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure

(2018) Peter D. Kwong et al.   IMMUNITY

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

(2018) Norbert Pardi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees

(2018) Nicole L. Yates et al.   JOURNAL OF VIROLOGY

Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19)

(2018) Dan H Barouch et al.   LANCET

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV

(2018) Margaret E. Ackerman et al.   NATURE MEDICINE

Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers

(2018) Yoann Aldon et al.   Cell Reports

Germline-targeting immunogens

(2017) Leonidas Stamatatos et al.   IMMUNOLOGICAL REVIEWS

HIV-1 gp120 and Modified Vaccinia Virus Ankara (MVA) gp140 Boost Immunogens Increase Immunogenicity of a DNA/MVA HIV-1 Vaccine

(2017) Xiaoying Shen et al.   JOURNAL OF VIROLOGY

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

(2017) Norbert Pardi et al.   NATURE

Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies

(2017) Mattia Bonsignori et al.   Science Translational Medicine

Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge

(2017) Todd Bradley et al.   Nature Communications

Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations

(2017) Wilton B. Williams et al.   Nature Communications

Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains

(2017) M. Gordon Joyce et al.   Cell Reports

Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates

(2017) Kevin O. Saunders et al.   Cell Reports

Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models

(2017) Kevin O. Saunders et al.   Cell Reports

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

(2017) Tongqing Zhou et al.   Cell Reports

Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors

(2016) Beatriz Pacheco et al.   JOURNAL OF VIROLOGY

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses

(2016) Matthew Zirui Tay et al.   PLoS Pathogens

Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity

(2016) Todd Bradley et al.   EBioMedicine

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

(2015) Steven W. de Taeye et al.   CELL

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost

(2015) Sandrine L. Hulot et al.   JOURNAL OF VIROLOGY

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

(2015) Andreas Thess et al.   MOLECULAR THERAPY

Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies

(2014) Feng Gao et al.   CELL

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials

(2014) Anna Sambor et al.   JOURNAL OF IMMUNOLOGICAL METHODS

HIV-1 Vaccine-Induced C1 and V2 Env-Specific Antibodies Synergize for Increased Antiviral Activities

(2014) Justin Pollara et al.   JOURNAL OF VIROLOGY

Vaccine-Induced IgG Antibodies to V1V2 Regions of Multiple HIV-1 Subtypes Correlate with Decreased Risk of HIV-1 Infection

(2014) Susan Zolla-Pazner et al.   PLoS One

Host Controls of HIV Neutralizing Antibodies

(2014) B. F. Haynes et al.   SCIENCE

Epitope Specificity of Human Immunodeficiency Virus-1 Antibody Dependent Cellular Cytotoxicity [ADCC] Responses

(2013) Justin Pollara et al.   CURRENT HIV RESEARCH

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

(2013) Hua-Xin Liao et al.   IMMUNITY

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

(2013) Martin A Maier et al.   MOLECULAR THERAPY

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

(2013) Hua-Xin Liao et al.   NATURE

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antigenicity and Immunogenicity of RV144 Vaccine AIDSVAX Clade E Envelope Immunogen Is Enhanced by a gp120 N-Terminal Deletion

(2012) S. Munir Alam et al.   JOURNAL OF VIROLOGY

Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: a post-hoc analysis of the Thai phase 3 efficacy trial RV 144

(2012) Merlin L Robb et al.   LANCET INFECTIOUS DISEASES

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

(2012) Morgane Rolland et al.   NATURE

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

(2012) Dan H. Barouch et al.   NATURE

B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

(2012) Barton F Haynes et al.   NATURE BIOTECHNOLOGY

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses

(2011) Justin Pollara et al.   CYTOMETRY PART A

An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 Serum

(2011) G. Ferrari et al.   JOURNAL OF VIROLOGY

Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors

(2011) M. Bonsignori et al.   JOURNAL OF VIROLOGY

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples

(2010) Margaret E. Ackerman et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY