Determinants and dynamics of pancreatic islet architecture

Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes

(2021) Louise Cottle et al.   DIABETOLOGIA

Proteome-wide and matrisome-specific alterations during human pancreas development and maturation

(2021) Zihui Li et al.   Nature Communications

PDX1LOW MAFALOW β-cells contribute to islet function and insulin release

(2021) Daniela Nasteska et al.   Nature Communications

Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells

(2021) Melissa T Adams et al.   eLife

A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion

(2020) Aharon Helman et al.   Cell Metabolism

The extracellular matrix in development

(2020) David A. Cruz Walma et al.   DEVELOPMENT

Pancreatic Islets and Gestalt Principles

(2020) Michael P. Dybala et al.   DIABETES

A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation

(2020) Corinna Cozzitorto et al.   DEVELOPMENTAL CELL

Tracing the cellular basis of islet specification in mouse pancreas

(2020) Magdalena K. Sznurkowska et al.   Nature Communications

Reconstructing human pancreatic islet architectures using computational optimization

(2020) Gerardo J. Félix-Martínez et al.   Islets

Assessing the origin and velocity of Ca2+ waves in three-dimensional tissue: Insights from a mathematical model and confocal imaging in mouse pancreas tissue slices

(2020) Marko Šterk et al.   Communications in Nonlinear Science and Numerical Simulation

A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets

(2019) Nadav Sharon et al.   CELL

Pancreatic pericytes originate from the embryonic pancreatic mesenchyme

(2019) Neta Harari et al.   DEVELOPMENTAL BIOLOGY

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes

(2019) Yue J. Wang et al.   Cell Metabolism

Heterogeneity of the Human Pancreatic Islet

(2019) Michael P. Dybala et al.   DIABETES

Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing

(2019) Francesco Volta et al.   Nature Communications

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

(2018) Xiangwei Xiao et al.   Cell Stem Cell

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges

(2018) Julie B. Sneddon et al.   Cell Stem Cell

Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca 2+ Sensitivity of Insulin Secretion Vesicles

(2018) Chen Huang et al.   DEVELOPMENTAL CELL

New Understanding of β-Cell Heterogeneity and In Situ Islet Function

(2018) Richard K.P. Benninger et al.   DIABETES

Endocrine cell type sorting and mature architecture in the islets of Langerhans require expression of Roundabout receptors in β cells

(2018) Melissa T. Adams et al.   Scientific Reports

A new mode of pancreatic islet innervation revealed by live imaging in zebrafish

(2018) Yu Hsuan Carol Yang et al.   eLife

Lineage dynamics of murine pancreatic development at single-cell resolution

(2018) Lauren E. Byrnes et al.   Nature Communications

Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas

(2018) Lydia Farack et al.   DEVELOPMENTAL CELL

Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature

(2018) Alexis M Ceasrine et al.   eLife

δ-cells and β-cells are electrically coupled and regulate α-cell activity via somatostatin

(2017) L. J. B. Briant et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice

(2017) Haruka Okamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular and morphogenetic basis of pancreas organogenesis

(2017) Hjalte List Larsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

αE-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation

(2017) Antonio J. Jimenez-Caliani et al.   Cell Reports

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site

(2017) Andrew R. Pepper et al.   Stem Cell Reports

Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells

(2017) Aimée Bastidas-Ponce et al.   Molecular Metabolism

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation

(2016) Marta Szabat et al.   Cell Metabolism

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Cell rearrangement in transplanted human islets

(2016) Vanessa Lavallard et al.   FASEB JOURNAL

Precommitment low-levelNeurog3expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells

(2016) Matthew E. Bechard et al.   GENES & DEVELOPMENT

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

Impact of islet architecture on β-cell heterogeneity, plasticity and function

(2016) Sara S. Roscioni et al.   Nature Reviews Endocrinology

A comparison of the anatomical structure of the pancreas in experimental animals

(2016) Minoru Tsuchitani et al.   Journal of Toxicologic Pathology

Design Principles of Pancreatic Islets: Glucose-Dependent Coordination of Hormone Pulses

(2016) Danh-Tai Hoang et al.   PLoS One

Pancreatic Mesenchyme Regulates Islet Cellular Composition in a Patched/Hedgehog-Dependent Manner

(2016) Daniel Hibsher et al.   Scientific Reports

Matrix Metalloproteinase-9 Is Essential for Physiological Beta Cell Function and Islet Vascularization in Adult Mice

(2015) Gustaf Christoffersson et al.   AMERICAN JOURNAL OF PATHOLOGY

MesenchymalHox6function is required for mouse pancreatic endocrine cell differentiation

(2015) Brian M. Larsen et al.   DEVELOPMENT

Weaning Triggers a Maturation Step of Pancreatic β Cells

(2015) Miri Stolovich-Rain et al.   DEVELOPMENTAL CELL

New insights into the architecture of the islet of Langerhans: a focused cross-species assessment

(2015) Rafael Arrojo e Drigo et al.   DIABETOLOGIA

Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic  -cell function

(2015) S. Jia et al.   EMBO JOURNAL

Human Islet Morphology Revisited

(2015) Susan Bonner-Weir et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Alpha-, Delta- and PP-cells

(2015) Melissa F. Brereton et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes

(2015) Leslie S. Satin et al.   MOLECULAR ASPECTS OF MEDICINE

Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism

(2015) Danny Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Edges of Pancreatic Islet β Cells Constitute Adhesive and Signaling Microdomains

(2015) Erez Geron et al.   Cell Reports

A 3D map of the islet routes throughout the healthy human pancreas

(2015) Constantin Ionescu-Tirgoviste et al.   Scientific Reports

Intrinsic Islet Heterogeneity and Gap Junction Coupling Determine Spatiotemporal Ca2+ Wave Dynamics

(2014) Richard K.P. Benninger et al.   BIOPHYSICAL JOURNAL

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Islet Microenvironment, Modulated by Vascular Endothelial Growth Factor-A Signaling, Promotes β Cell Regeneration

(2014) Marcela Brissova et al.   Cell Metabolism

Cdc42/N-WASP signaling links actin dynamics to pancreatic   cell delamination and differentiation

(2014) G. Kesavan et al.   DEVELOPMENT

Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding

(2014) R. B. Reinert et al.   DEVELOPMENT

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth

(2014) Yan Hang et al.   DIABETES

Fluorescence recovery after photobleaching reveals regulation and distribution of connexin36 gap junction coupling within mouse islets of Langerhans

(2014) Nikki L. Farnsworth et al.   JOURNAL OF PHYSIOLOGY-LONDON

Incretin-Modulated Beta Cell Energetics in Intact Islets of Langerhans

(2014) David J. Hodson et al.   MOLECULAR ENDOCRINOLOGY

Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells

(2014) Weida Li et al.   NATURE BIOTECHNOLOGY

A Conserved Rule for Pancreatic Islet Organization

(2014) Danh-Tai Hoang et al.   PLoS One

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

(2014) Melissa F. Brereton et al.   Nature Communications

Phase Transitions in the Multi-cellular Regulatory Behavior of Pancreatic Islet Excitability

(2014) Thomas H. Hraha et al.   PLoS Computational Biology

α-Cells are dispensable in postnatal morphogenesis and maturation of mouse pancreatic islets

(2013) Chiyo Shiota et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pancreas Organogenesis: From Lineage Determination to Morphogenesis

(2013) Hung Ping Shih et al.   Annual Review of Cell and Developmental Biology

Vascular Endothelial Growth Factor-A and Islet Vascularization Are Necessary in Developing, but Not Adult, Pancreatic Islets

(2013) R. B. Reinert et al.   DIABETES

Molecular basis for the regulation of islet beta cell mass in mice: the role of E-cadherin

(2013) N. Wakae-Takada et al.   DIABETOLOGIA

Sympathetic Innervation during Development Is Necessary for Pancreatic Islet Architecture and Functional Maturation

(2013) Philip Borden et al.   Cell Reports

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation

(2012) Qing Cai et al.   DEVELOPMENTAL BIOLOGY

Markedly Decreased Blood Perfusion of Pancreatic Islets Transplanted Intraportally Into the Liver: Disruption of Islet Integrity Necessary for Islet Revascularization

(2012) J. Henriksnas et al.   DIABETES

Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling

(2012) A. V. Matveyenko et al.   DIABETES

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Dysregulation of Dicer1 in Beta Cells Impairs Islet Architecture and Glucose Metabolism

(2012) Amitai D. Mandelbaum et al.   Experimental Diabetes Research

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

(2012) Barak Blum et al.   NATURE BIOTECHNOLOGY

Deconstructing Pancreas Developmental Biology

(2012) C. M. Benitez et al.   Cold Spring Harbor Perspectives in Biology

Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development

(2011) Mathieu Gouzi et al.   DEVELOPMENTAL DYNAMICS

Pancreas organogenesis: From bud to plexus to gland

(2011) Fong Cheng Pan et al.   DEVELOPMENTAL DYNAMICS

Glucose- and Hormone-Induced cAMP Oscillations in  - and  -Cells Within Intact Pancreatic Islets

(2011) G. Tian et al.   DIABETES

Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet

(2011) R. K. P. Benninger et al.   JOURNAL OF PHYSIOLOGY-LONDON

Altered Islet Composition and Disproportionate Loss of Large Islets in Patients with Type 2 Diabetes

(2011) German Kilimnik et al.   PLoS One

Pancreatic Mesenchyme Regulates Epithelial Organogenesis throughout Development

(2011) Limor Landsman et al.   PLOS BIOLOGY

Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

(2010) Chunyan Gu et al.   Cell Metabolism

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

N-cadherin is dispensable for pancreas development but required for β-cell granule turnover

(2010) Jenny K. Johansson et al.   GENESIS

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Islet architecture: A comparative study

(2010) Abraham Kim et al.   Islets

Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition

(2010) Donald J. Steiner et al.   Islets

Rac1 regulates pancreatic islet morphogenesis

(2009) Thomas U Greiner et al.   BMC DEVELOPMENTAL BIOLOGY

No mantle formation in rodent islets—The prototype of islet revisited

(2009) Michael Kharouta et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Endocrine Cell Clustering During Human Pancreas Development

(2009) Jongmin Jeon et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and β-Cell Proliferation during Embryogenesis

(2009) Laura A. Crawford et al.   MOLECULAR ENDOCRINOLOGY

Islet Formation during the Neonatal Development in Mice

(2009) Kevin Miller et al.   PLoS One

Newcomer insulin secretory granules as a highly calcium-sensitive pool

(2009) M. G. Pedersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of β-cell mass in response to pregnancy

(2009) Sebastian Rieck et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inhibition of Ca2+ signaling and glucagon secretion in mouse pancreatic α-cells by extracellular ATP and purinergic receptors

(2008) Eva Tudurí et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Gap Junction Coupling and Calcium Waves in the Pancreatic Islet

(2008) Richard K.P. Benninger et al.   BIOPHYSICAL JOURNAL

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY