RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells

Aptamers against mouse and human tumor-infiltrating myeloid cells as reagents for targeted chemotherapy

(2020) Adriana De La Fuente et al.   Science Translational Medicine

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies

(2019) Evangeline M. Foster et al.   Frontiers in Neuroscience

Is it useful to use several “omics” for obtaining valuable results?

(2019) Magdalena Zapalska-Sozoniuk et al.   MOLECULAR BIOLOGY REPORTS

Brain clusterin protein isoforms and mitochondrial localization

(2019) Sarah K Herring et al.   eLife

Concentration-Dependency and Time Profile of Insulin Secretion: Dynamic Perifusion Studies With Human and Murine Islets

(2019) Oscar Alcazar et al.   Frontiers in Endocrinology

Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging

(2018) Gary W. Cline et al.   DIABETOLOGIA

Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer

(2018) Vikash Reebye et al.   ONCOGENE

A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT): POST (Prospective Observational Study of TPIAT)

(2018) Melena D. Bellin et al.   PANCREATOLOGY

The journey of islet cell transplantation and future development

(2018) Anissa Gamble et al.   Islets

XIAP at the crossroads of cell death and inflammation

(2018) Domagoj Vucic   Oncotarget

In Vivo Imaging of Transplanted Pancreatic Islets

(2018) Donghee Kim et al.   Frontiers in Endocrinology

Analyzing the Genotoxicity of Retroviral Vectors in Hematopoietic Cell Gene Therapy

(2018) Luca Biasco et al.   Molecular Therapy-Methods & Clinical Development

Predicting protein targets for drug-like compounds using transcriptomics

(2018) Nicolas A. Pabon et al.   PLoS Computational Biology

All mixed up: defining roles for β-cell subtypes in mature islets

(2017) Jennifer S.E. Liu et al.   GENES & DEVELOPMENT

Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer

(2017) Jon Voutila et al.   MOLECULAR THERAPY

FDA-Approved Oligonucleotide Therapies in 2017

(2017) Cy A. Stein et al.   MOLECULAR THERAPY

Islet Cell Yield Following Remote Total Pancreatectomy With Islet Autotransplant is Independent of Cold Ischemia Time

(2017) Samuel J. Kesseli et al.   PANCREAS

Effects of Composition of Alginate-Polyethylene Glycol Microcapsules and Transplant Site on Encapsulated Islet Graft Outcomes in Mice

(2017) Chiara Villa et al.   TRANSPLANTATION

Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis

(2017) Chunguang Chen et al.   Molecular Metabolism

Single-donor islet transplantation in type 1 diabetes: patient selection and special considerations

(2017) Jacob Tatum et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Radioiodinated Exendin-4 Is Superior to the Radiometal-Labelled Glucagon-Like Peptide-1 Receptor Probes Overcoming Their High Kidney Uptake

(2017) Tilman Läppchen et al.   PLoS One

Clusterin: full-length protein and one of its chains show opposing effects on cellular lipid accumulation

(2017) Suvarsha Rao Matukumalli et al.   Scientific Reports

PAA: an R/bioconductor package for biomarker discovery with protein microarrays

(2016) Michael Turewicz et al.   BIOINFORMATICS

saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription

(2016) Victoria Portnoy et al.   CELL RESEARCH

In vivo imaging of beta cells with radiotracers: state of the art, prospects and recommendations for development and use

(2016) Olof Eriksson et al.   DIABETOLOGIA

Targets and probes for non-invasive imaging of β-cells

(2016) Andreas Jodal et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Insulitis in the pathogenesis of type 1 diabetes

(2016) Alberto Pugliese   PEDIATRIC DIABETES

From selection hits to clinical leads: progress in aptamer discovery

(2016) Keith E Maier et al.   Molecular Therapy-Methods & Clinical Development

Sample preparation strategies for improving the identification of membrane proteins by mass spectrometry

(2015) Javier Alfonso-Garrido et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

MR Imaging Monitoring of Iron-Labeled Pancreatic Islets in a Small Series of Patients: Islet Fate in Successful, Unsuccessful, and Autotransplantation

(2015) Maria Luisa Malosio et al.   CELL TRANSPLANTATION

Immunocapture strategies in translational proteomics

(2015) Claudia Fredolini et al.   Expert Review of Proteomics

Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer’s Disease

(2015) Hui-Chung Liang et al.   JOURNAL OF PROTEOME RESEARCH

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

p24 family proteins: key players in the regulation of trafficking along the secretory pathway

(2015) Noelia Pastor-Cantizano et al.   PROTOPLASMA

Monitoring of Allogeneic Islet Grafts in Nonhuman Primates Using MRI

(2015) Ping Wang et al.   TRANSPLANTATION

Total Pancreatectomy with Islet Autologous Transplantation: The Cure for Chronic Pancreatitis?

(2015) Samuel J Kesseli et al.   Clinical and Translational Gastroenterology

Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A

(2015) Sindhu Rajan et al.   Molecular Metabolism

Non-invasive quantification of the beta cell mass by SPECT with 111In-labelled exendin

(2014) Maarten Brom et al.   DIABETOLOGIA

Glucagon-like-peptide-1 receptor expression in normal and diseased human thyroid and pancreas

(2014) Beatrice Waser et al.   MODERN PATHOLOGY

Targeting the pancreatic β-cell to treat diabetes

(2014) Amedeo Vetere et al.   NATURE REVIEWS DRUG DISCOVERY

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

(2014) J. Fadista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Donor Islet Transplantation and Long-term Insulin Independence in Select Patients With Type 1 Diabetes Mellitus

(2014) David P. Al-Adra et al.   TRANSPLANTATION

Beta cell imaging – a key tool in optimized diabetes prevention and treatment

(2014) Martin Gotthardt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

X-Linked Inhibitor of Apoptosis Protein – A Critical Death Resistance Regulator and Therapeutic Target for Personalized Cancer Therapy

(2014) Petra Obexer et al.   Frontiers in Oncology

Non-Secreted Clusterin Isoforms Are Translated in Rare Amounts from Distinct Human mRNA Variants and Do Not Affect Bax-Mediated Apoptosis or the NF-κB Signaling Pathway

(2013) Hans Prochnow et al.   PLoS One

In Vivo Imaging of Endogenous Pancreatic  -Cell Mass in Healthy and Type 1 Diabetic Subjects Using 18F-Fluoropropyl-Dihydrotetrabenazine and PET

(2012) M. D. Normandin et al.   JOURNAL OF NUCLEAR MEDICINE

Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk

(2012) I-Fang Ling et al.   PLoS One

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Thermal Stability of siRNA Modulates Aptamer- conjugated siRNA Inhibition

(2012) Alexey Berezhnoy et al.   Molecular Therapy-Nucleic Acids

Essential role of clusterin in pancreas regeneration

(2011) Song Lee et al.   DEVELOPMENTAL DYNAMICS

Semen Clusterin Is a Novel DC-SIGN Ligand

(2011) Juan Sabatte et al.   JOURNAL OF IMMUNOLOGY

Transmembrane Emp24 Protein Transport Domain 6 is Selectively Expressed in Pancreatic Islets and Implicated in Insulin Secretion and Diabetes

(2011) Xiaochun Wang et al.   PANCREAS

Apolipoprotein J/Clusterin Is a Novel Structural Component of Human Erythrocytes and a Biomarker of Cellular Stress and Senescence

(2011) Marianna H. Antonelou et al.   PLoS One

In Vivo Beta-Cell Imaging with VMAT 2 Ligands - Current State-of-the-Art and Future Perspectives

(2010) Rajakrishnan Veluthakal et al.   CURRENT PHARMACEUTICAL DESIGN

Overcoming Key Technological Challenges in Using Mass Spectrometry for Mapping Cell Surfaces in Tissues

(2010) Noelle M. Griffin et al.   MOLECULAR & CELLULAR PROTEOMICS

XIAP Gene Expression Protects β-Cells and Human Islets from Apoptotic Cell Death

(2010) Hao Wu et al.   MOLECULAR PHARMACEUTICS

Magnetic Resonance Imaging of Pancreatic Islets Transplanted Into the Liver in Humans

(2010) František Saudek et al.   TRANSPLANTATION

XIAP inhibition of β-cell apoptosis reduces the number of islets required to restore euglycemia in a syngeneic islet transplantation model

(2010) Annette Plesner et al.   Islets

11C-Dihydrotetrabenazine PET of the Pancreas in Subjects with Long-Standing Type 1 Diabetes and in Healthy Controls

(2009) R. Goland et al.   JOURNAL OF NUCLEAR MEDICINE

Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications

(2009) Frederic Leblond et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Clusterin, a Haploinsufficient Tumor Suppressor Gene in Neuroblastomas

(2009) Olesya Chayka et al.   JNCI-Journal of the National Cancer Institute

A Comprehensive Overview of the Vertebrate p24 Family: Identification of a Novel Tissue-Specifically Expressed Member

(2009) J. R.P.M. Strating et al.   MOLECULAR BIOLOGY AND EVOLUTION

Meta-analysis of gene expression in human pancreatic islets after in vitro expansion

(2009) B. Kutlu et al.   PHYSIOLOGICAL GENOMICS

Identification and characterization of glycosylation sites in human serum clusterin

(2009) James T. Kapron et al.   PROTEIN SCIENCE

Clinical Magnetic Resonance Imaging of Pancreatic Islet Grafts After Iron Nanoparticle Labeling

(2008) C. Toso et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Plasma–Fibroblast Gel as Scaffold for Islet Transplantation

(2008) Marcos Perez-Basterrechea et al.   TISSUE ENGINEERING PART A

Application of Proteomics in the Discovery of Candidate Protein Biomarkers in a Diabetes Autoantibody Standardization Program Sample Subset

(2007) Thomas O. Metz et al.   JOURNAL OF PROTEOME RESEARCH