Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer

saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription

(2016) Victoria Portnoy et al.   CELL RESEARCH

Time trends in the health care burden and mortality of acute on chronic liver failure in the United States

(2016) Alina M. Allen et al.   HEPATOLOGY

Treatment of Patients with Cirrhosis

(2016) Phillip S. Ge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up

(2015) Mattias Ekstedt et al.   HEPATOLOGY

Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide

(2014) Wendi V. Rodrigueza et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

C/EBPα inhibits hepatocellular carcinoma by reducing Notch3/Hes1/p27 cascades

(2013) Yi-Chao Shi et al.   DIGESTIVE AND LIVER DISEASE

Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesisin vivo

(2013) Vikash Reebye et al.   HEPATOLOGY

Age-associated Change of C/EBP Family Proteins Causes Severe Liver Injury and Acceleration of Liver Proliferation after CCl4Treatments

(2013) Il-Hwa Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C/EBP-α ameliorates CCl4-induced liver fibrosis in mice through promoting apoptosis of hepatic stellate cells with little apoptotic effect on hepatocytes in vitro and in vivo

(2012) Li-Li Tao et al.   APOPTOSIS

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

Small RNA and transcriptional upregulation

(2011) Victoria Portnoy et al.   Wiley Interdisciplinary Reviews-RNA

C/EBPα Is Up-regulated in a Subset of Hepatocellular Carcinomas and Plays a Role in Cell Growth and Proliferation

(2010) Guo–Dong Lu et al.   GASTROENTEROLOGY

Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection

(2010) Brad Q. Starley et al.   HEPATOLOGY