Article
Oncology
Steven P. Rowe, Martin G. Pomper
Summary: Molecular imaging, defined as visualizing, characterizing, and measuring biological processes at the molecular and cellular levels, has rapidly developed in recent years, with a particular focus on oncology for early detection and optimal disease management. The expansion of molecular imaging is driven by new animal models, sensitive imaging devices, high-throughput methods, genetic manipulation techniques, and cloud computing. Researchers and clinicians are utilizing molecular imaging for a variety of physiological processes, with a focus on oncology for its potential in detecting diseases at an early stage.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Review
Endocrinology & Metabolism
Takaaki Murakami, Hiroyuki Fujimoto, Nobuya Inagaki
Summary: Pancreatic beta-cell dysfunction and reduced mass are central in diabetes, but non-invasive evaluation of beta-cell mass remains elusive. Recent nuclear medical techniques using GLP-1R-targeted imaging probes show promise in evaluating beta-cell mass in diabetes management.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Oncology
Isabel Theresa Schobert, Lynn Jeanette Savic
Summary: Deregulated tumor metabolism in liver cancer leads to heterogeneous response rates to treatments, making personalized therapy selection crucial. Non-invasive imaging techniques focusing on the crosstalk between tumor cells and their microenvironment aim to improve tumor detection and guide personalized treatment regimens. Understanding tumor metabolism through imaging technologies may help identify suitable therapies and design targeted treatments to overcome resistance mechanisms in liver cancer.
Article
Biochemistry & Molecular Biology
Pierre Cheung, Olof Eriksson
Summary: Diabetes is a chronic metabolic disease that affects over 400 million people globally, with traditional diagnostic methods having limitations in accurately reflecting disease progression. Studying beta-cell mass is crucial for understanding disease processes, but invasive procedures are required. Nuclear medical imaging techniques offer a non-invasive approach for studying beta-cell mass, potentially leading to breakthroughs in diabetes research and therapies.
Review
Health Care Sciences & Services
Igino Simonetti, Piero Trovato, Vincenza Granata, Carmine Picone, Roberta Fusco, Sergio Venanzio Setola, Mauro Mattace Raso, Corrado Caraco, Paolo A. Ascierto, Fabio Sandomenico, Antonella Petrillo
Summary: Interval metastasis is a specific type of lymph node metastasis in patients with melanoma. Imaging techniques such as ultrasound, CT, MRI, lymphoscintigraphy, and PET are used for evaluation. Understanding these methods and collaborating with clinicians are essential for treatment and survival.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Valeria Romeo, Thomas H. Helbich, Katja Pinker
Summary: The recent introduction of hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) as a promising imaging modality for breast cancer assessment has sparked extensive research on its clinical applications. This state-of-the-art review provides an overview of advanced MRI techniques, PET tracers, and the use of radiomics and artificial intelligence techniques in hybrid breast PET/MRI. The strengths and limitations of hybrid PET/MRI in the real world are also discussed.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Masaya Kawaguchi, Hiroki Kato, Yoshifumi Noda, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Fuminori Hyodo, Masayuki Matsuo
Summary: Accurate preoperative diagnosis is crucial for malignant skin tumors (MSTs) due to the different clinical management required for each histological subtype. Radiological imaging plays a significant role in evaluating the extent of local invasion, nodal involvement, and distant metastasis in MSTs. Recent studies have identified characteristic radiological features that aid in the differential diagnosis of MSTs, such as configuration, intratumoral homogeneity, signal intensity, cyst formation, and hemorrhage. Clinical data, including age, gender, and site of occurrence, are also important for determining the histological subtype of MSTs.
INSIGHTS INTO IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Ponsiglione, Arnaldo Stanzione, Gaia Spadarella, Agah Baran, Luca Alessandro Cappellini, Kevin Groot Lipman, Peter Van Ooijen, Renato Cuocolo
Summary: The overall methodological rigor of radiomics studies in the ovarian field is not ideal, with a lack of prospective design and formal validation of results. This limits the reproducibility of results and potential translation to clinical setting.
EUROPEAN RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Trinh Nguyen, Akshya Gupta, Shweta Bhatt
Summary: Lymphomatous involvement of the genitourinary system, particularly the kidneys, is often underestimated and underreported on conventional diagnostic imaging. This is due to its variable imaging appearance and overlapping features with other conditions. By presenting a spectrum of typical and atypical appearances of renal lymphoma using multimodality imaging, this article highlights the importance of imaging in the detection, diagnosis, staging, and surveillance of patients with lymphoma.
INSIGHTS INTO IMAGING
(2022)
Review
Immunology
Wenxia Dong, Ning Wang, Zhe Qi
Summary: The prevalence of brain cancer is increasing and brings significant healthcare challenges. Immunotherapies present diagnostic imaging challenges for brain tumors. Effective neuroimaging techniques are necessary for diagnosing and monitoring brain tumors, but differentiating between tumors and necrotic lesions or inflamed tissues remains a challenge. This review summarizes recent advances in neuroimaging methods for enhancing brain tumor diagnosis and evaluating inflamed lesions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Thomas T. Poels, Floris A. Vuijk, Lioe-Fee de Geus-Oei, Alexander L. Vahrmeijer, Daniela E. Oprea-Lager, Rutger-Jan Swijnenburg
Summary: This review discusses the use of more specific diagnostic imaging modalities for pancreatic ductal adenocarcinoma (PDAC) that evaluate the presence of specific tumour tracers via positron emission tomography, as well as the available therapeutic applications of these tumour-specific tracers.
Article
Chemistry, Multidisciplinary
Sara F. F. Almeida, Alexandra Fonseca, Jose Sereno, Hugo R. S. Ferreira, Mariana Lapo-Pais, Tania Martins-Marques, Teresa Rodrigues, Rui C. Oliveira, Catarina Miranda, Luis P. Almeida, Henrique Girao, Amilcar Falcao, Antero J. Abrunhosa, Celia M. Gomes
Summary: This study develops an imaging tool using exosomes derived from osteosarcoma cells as natural nanocarriers for the noninvasive detection of lung micrometastasis. The results demonstrate that these exosomes accumulate specifically in metastatic lesions and primary tumors in vivo, showing excellent targeting ability. Optical imaging using exosomes is also able to detect lung metastasis. These findings suggest that tumor-derived exosomes have great potential as targeted imaging agents for the noninvasive detection of small lung metastasis using PET.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaofang Ban, Zhaoyue Li, Yuchen Duan, Ke Xu, Jie Xiong, Yingfeng Tu
Summary: This article reviews advanced techniques for coronary artery calcification imaging and their potential applications in both experimental and clinical settings, which provide the ability for early and accurate assessment of calcium content in atherosclerotic plaques.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Review
Biology
Kevin Hamzaraj, Andreas Kammerlander, Mariann Gyoengyoesi, Bernhard Frey, Klaus Distelmaier, Senta Graf
Summary: Percutaneous coronary intervention of chronic total occlusion (CTO PCI) is a challenging procedure with high complication rates and uncertain long-term clinical benefits. Relief of ischemic symptoms in high ischemic burden patients is the only established indication for CTO PCI. Non-invasive cardiac imaging techniques are crucial in selecting candidates for revascularization.
Article
Cardiac & Cardiovascular Systems
Aylina Glasenapp, Katja Derlin, Marcel Gutberlet, Annika Hess, Tobias L. Ross, Hans-Juergen Wester, Frank M. Bengel, James T. Thackeray
Summary: The study focused on investigating the interplay between ventricle loading conditions, tissue inflammation, and progressive fibrosis in pressure overload heart failure using noninvasive multimodality molecular imaging. Inflammation and fibrosis play crucial roles in the early response to pressure overload and can be sensitively monitored by multimodality imaging, which may guide novel treatment strategies in nonischemic heart failure.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Soo Lim, Gha Young Lee, Ho Seon Park, Dong-Hwa Lee, Oh Tae Jung, Kim Kyoung Min, Young-Bum Kim, Hee-Sook Jun, Hak Chul Jang, Kyong Soo Park
CARDIOVASCULAR RESEARCH
(2017)
Review
Biochemistry & Molecular Biology
Yoon Sin Oh, Hee-Sook Jun
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Chemistry, Organic
Wei Sun, Yue Yuan, Bit Lee, Hee-Sook Jun, Dongyun Shin, Seung-Yong Seo
Article
Biochemistry & Molecular Biology
Eunhui Seo, Hwansu Kang, Oh-Kyung Lim, Hee-Sook Jun
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biotechnology & Applied Microbiology
Se-Ra Park, Jae-Wan Kim, Hee-Sook Jun, Joo Young Roh, Hwa-Yong Lee, In-Sun Hong
Article
Multidisciplinary Sciences
Duy Trong Vien Diep, Kyungki Hong, Triyeng Khun, Mei Zheng, Asad ul-Haq, Hee-Sook Jun, Young-Bum Kim, Kwang-Hoon Chun
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Jitendra Shrestha, Sung Hwan Ki, Sang Mi Shin, Seon Woong Kim, Joo-Youn Lee, Hee-Sook Jun, Taeho Lee, Sanghee Kim, Dong Jae Baek, Eun-Young Park
Article
Cell Biology
Younghay Lee, Sun-Hye Shin, Kyung-Ah Cho, Yu-Hee Kim, So-Youn Woo, Han Su Kim, Sung-Chul Jung, Inho Jo, Hee-Sook Jun, Woo-Jae Park, Joo-Won Park, Kyung-Ha Ryu
Review
Biochemistry & Molecular Biology
Jong Han Lee, Donghee Kim, Yoon Sin Oh, Hee-Sook Jun
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Yun Jung Oh, Hyunsook Kim, Ae Jin Kim, Han Ro, Jae Hyun Chang, Hyun Hee Lee, Wookyung Chung, Hee-Sook Jun, Ji Yong Jung
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Donghee Kim, Hyo-Jin Kim, Jin-Ok Baek, Joo-Young Roh, Hee-Sook Jun
Summary: The study revealed that LPAR1/3 antagonist alleviates IMQ-induced psoriasis-like symptoms in mice, with LPAR1 signaling playing a crucial role in cell cycle progression in keratinocytes via the ROCK2/PI3K/AKT pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Geon-Ho Lee, Jayeon Cheon, Donghee Kim, Hee-Sook Jun
Summary: LPA promotes EMT and renal tubular fibrosis through LPAR1 signaling, downregulating E-cadherin and upregulating vimentin expression. This effect is mediated by regulation of KLF5 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ka-Yun Ban, Ga-Young Nam, Donghee Kim, Yoon Sin Oh, Hee-Sook Jun
Summary: Bavachin has a protective effect on lipopolysaccharide-induced acute kidney injury by inhibiting oxidative stress and inflammation through the downregulation of the PKC beta/MAPK/KLF5 axis.
Article
Biochemistry & Molecular Biology
Myeong-Hoon Yeon, Eunhui Seo, Jong-Han Lee, Hee-Sook Jun
Summary: Bavachin and corylifol A extracted from Psoralea corylifolia L. seeds can enhance muscle strength and mass, suppress inflammation, and improve mitochondrial function, thus potentially exerting therapeutic effects on muscle atrophy.
