Article
Endocrinology & Metabolism
Selina Wrublewsky, Thimoteus Speer, Lisa Nalbach, Anne S. Boewe, Mandy Pack, Dalia Alansary, Leticia P. Roma, Markus D. A. Hoffmann, Beate M. Schmitt, Andrea Weinzierl, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo
Summary: The inhibition of NLRP3 improves the survival and endocrine function of pancreatic islet grafts by enhancing revascularization and inducing insulin gene expression. This inhibition has significant therapeutic potential in pancreatic islet transplantation.
Editorial Material
Cell Biology
Laura Crisa, Vincenzo Cirulli
Summary: In their recent paper, Chang and colleagues successfully achieved durable mixed hematopoietic chimerism that promotes the engraftment and long-term function of pancreatic islet allotransplants in fully immunocompetent mice without the need for immunosuppression.
Article
Surgery
Maria M. Coronel, Stephen W. Linderman, Karen E. Martin, Michael D. Hunckler, Juan D. Medina, Graham Barber, Kayle Riley, Esma S. Yolcu, Haval Shirwan, Andres J. Garcia
Summary: The induction of operational immune tolerance is a major goal in beta-cell replacement strategies for the treatment of type 1 diabetes. Biomaterial-mediated PD-L1 immunotherapy can prolong graft survival and metabolic function in islet transplantation and delay allograft rejection in diabetic NOD mice.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Biochemistry & Molecular Biology
Serena Barachini, Letizia Biso, Shivakumar Kolachalam, Lacopo Petrini, Roberto Maggio, Marco Scarselli, Biancamaria Longoni
Summary: Pancreatic islet transplantation is a treatment for Type 1 diabetic patients, and mesenchymal stem cells (MSCs) have shown potential in controlling graft rejection. MSCs can interact with immune system cells through direct contact or their secretome. This review discusses the role of MSCs in controlling the immune system and promoting repair in pancreatic islet transplantation, as well as challenges such as oxidative stress and impaired vasculogenesis. Preconditioning MSCs with hypoxia exposure or using stem cells with angiogenic potential in organoids may help improve transplant outcomes.
Review
Medicine, General & Internal
Beata Jablonska, Slawomir Mrowiec
Summary: Total pancreatectomy with autologous islet transplantation is a complex surgical procedure with potential benefits for patients with pancreatic conditions, but careful consideration of postoperative safety and long-term outcomes is necessary.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Selina Wrublewsky, Julia Glas, Christopher Carlein, Lisa Nalbach, Markus Daniel Alexander Hoffmann, Mandy Pack, Eloisa Aparecida Vilas-Boas, Nathan Ribot, Reinhard Kappl, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo, Leticia Prates Roma
Summary: Islet transplantation is a promising treatment for type 1 diabetes mellitus. This study found that suppressing the activity of NADPH oxidase 2 (NOX2) in islets improves their engraftment and function, suggesting it as a potential therapeutic strategy.
Article
Nanoscience & Nanotechnology
Gilbert Aaron Lee, Wan-Li Lin, Duen-Pang Kuo, Yi-Tien Li, Yu-Wei Chang, Yung-Chie Chen, Shiu-Wen Huang, Justin Bo-Kai Hsu, Cheng-Yu Chen
Summary: Lipid-coated SPIO nanoparticles conjugated with PD-L1 antibodies can specifically target PD-L1 expression in glioblastoma, including temozolomide-resistant cases, as demonstrated in this study through characterizations such as dynamic light scattering and in vivo T2* map MRI analysis. This approach shows promise for early diagnosis and predicting responses to targeted PD-L1 immunotherapy in glioblastoma patients.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Cell & Tissue Engineering
Ruth E. McDowell, Khawla F. Ali, Saloni Lad, Vicente T. San Martin, Rita Bottino, Matthew Walsh, Tyler Stevens, William Wilke, John P. Kirwan, Betul Hatipoglu
Summary: In patients undergoing total pancreatectomy and autologous islet transplantation (TPAIT) for chronic pancreatitis, pretreatment with the FDA-approved anti-inflammatory hydroxychloroquine (HCQ) may improve spare respiratory capacity (SRC) of islet preparations. Glycolytic metabolism of islet preparations may be a better indicator of in vivo islet function, and overnight culture should be avoided as it affects bioenergetic function of islet preparations.
CELL TRANSPLANTATION
(2021)
Article
Cell Biology
Jared M. Campbell, Stacey N. Walters, Abbas Habibalahi, Saabah B. Mahbub, Ayad G. Anwer, Shannon Handley, Shane T. Grey, Ewa M. Goldys
Summary: In this study, hyperspectral fluorescent microscopy was used to evaluate the spectral signals of islets, successfully distinguishing islet damage caused by oxidative stress, hypoxia, cytokine injury, and warm ischemia. An autofluorescent score for ischemic islets was defined, which accurately predicted the restoration of glucose control in diabetic recipients following transplantation.
Review
Endocrinology & Metabolism
Dian R. Arifin, Jeff W. M. Bulte
Summary: Pancreatic islet transplantation has the potential to provide life-long blood glucose management for diabetic patients, with imaging technology playing a crucial role in monitoring and evaluating the success of cell implants in vivo. Various imaging modalities are being developed to improve the precision and efficacy of islet therapy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Engineering, Biomedical
Alexandra M. Smink, Katarzyna Skrzypek, Jolanda A. L. Liefers-Visser, Rei Kuwabara, Bart J. de Haan, Paul de Vos, Dimitrios Stamatialis
Summary: Islet encapsulation in membrane-based devices provides a promising approach for transplanting donor islet tissue without the need for immunosuppression. Recent advancements in device design have led to improved support for islet survival and vascularization, showcasing the potential of this technology for islet transplantation.
BIOMEDICAL MATERIALS
(2021)
Review
Endocrinology & Metabolism
Fritz Cayabyab, Lina R. Nih, Eiji Yoshihara
Summary: Diabetes is a complex global disease affecting over 400 million people, with pancreatic islet transplantation showing promise in treating type 1 diabetes but facing challenges such as immune rejection. Current research focuses on finding optimal transplantation sites and methods to improve islet graft survival, with the aim of translating these studies into successful clinical therapies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Jordan Mattke, Srividya Vasu, Carly M. M. Darden, Kenjiro Kumano, Michael C. C. Lawrence, Bashoo Naziruddin
Summary: Exosomes play a crucial role in studying diagnostic markers for islet cell viability and function in islet transplantation. They may have an impact on the success of islet transplantation and could potentially be used as a therapeutic tool.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Daniel Brandhorst, Heide Brandhorst, Samuel Acreman, Anju Abraham, Paul R. Johnson
Summary: The study found that 5 μg/mL of Etanercept is the most effective dose for preserving the morphological and functional integrity of human islets during culture, with higher doses showing detrimental effects. Culturing human islets in clinically relevant hypoxia with 5 μg/mL of Etanercept significantly improved post-culture islet survival and in vitro function.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Medicine, General & Internal
Akiko Inagaki, Takehiro Imura, Yasuhiro Nakamura, Kazuo Ohashi, Masafumi Goto
Summary: The study investigated a novel method of liver surface transplantation using a syngeneic keratinocyte sheet to improve the transplant efficiency for curing diabetic rats. Although this approach showed effectiveness in curing diabetic rats, the transplant efficiency did not reach that of intraportal transplantation, indicating the need for further refinements to enhance the overall effectiveness of the procedure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Giovanni Peretto, Marco Merlo, Piero Gentile, Aldostefano Porcari, Anna Palmisano, Davide Vignale, Paola Sormani, Stefania Rizzo, Monica De Gaspari, Cristina Basso, Paolo Della Bella, Simone Sala, Enrico Ammirati, Gianfranco Sinagra, Antonio Esposito, Patrizia Pedrotti
Summary: This study evaluated the diagnostic sensitivity of cardiac magnetic resonance imaging based on Lake Louise criteria in patients with acute myocarditis. The results showed that using updated Lake Louise criteria increased the sensitivity of the diagnosis. It was also found that septal abnormalities were more common in patients with complicated acute myocarditis.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Silvia Pica, Gabriele Crimi, Serenella Castelvecchio, Vittorio Pazzanese, Anna Palmisano, Massimo Lombardi, Lara Tondi, Antonio Esposito, Pietro Ameri, Claudia Canale, Alberto Cappelletti, Luca P. Alberti, Davide Tavano, Rita Camporotondo, Ilaria Costantino, Jenness Campodonico, Gianluca Pontone, Alessandra Villani, Gianluca Pio Gallone, Rocco A. Montone, Giampaolo Niccoli, Paola Gargiulo, Bruna Punzo, Marco Vicenzi, Stefano Carugo, Lorenzo Menicanti, Giuseppe Ambrosio, Paolo G. Camici
Summary: This study investigated the presence of left ventricular (LV) remodelling after ST-elevation myocardial infarction (STEMI) using cardiac magnetic resonance (CMR) imaging. The results showed that LV remodelling in the subacute phase may not be detrimental, but rather a compensatory response associated with improved LV ejection fraction (EF) at follow-up. However, LV remodelling accompanied by an increase in end-systolic volume index (LV-REMESV) was associated with a decrease in LV-EF, driven by the infarct size.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Health Care Sciences & Services
Bruno Bernardini, Luigi Baratto, Costanza Pizzi, Annibale Biggeri, Giovanna Cerina, Viviana Colantonio, Carla Corsini, Sara Ghirmai, Marco Pagani, Stefania Fracchia, Marisa Gardella, Dolores Catelan, Maria Luisa Malosio, Elisa Malagamba
Summary: Objective: To develop and validate the Functional Risk Index for Dependence in Ambulation (FRIDA) score, a nomogram for predicting individual risk of dependence in ambulation at rehabilitation discharge. Results: The FRIDA score demonstrated good discrimination and calibration in predicting dependence in ambulation, both temporally and spatially. It is a clinically useful tool for predicting individual risk of dependence in ambulation and reflecting the case-mix composition of rehabilitation facilities.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Acoustics
Anna Palmisano, Davide Vignale, Elisa Bruno, Giovanni Peretto, Giacomo De Luca, Corrado Campochiaro, Alessandro Tomelleri, Eustachio Agricola, Matteo Montorfano, Antonio Esposito
Summary: In this study, CMR findings in patients with myocarditis-like syndrome during the acute and post-acute phase of COVID-19 were reported. The majority of cases were confirmed as myocarditis by CMR, with mild extent of lesions. Additionally, some patients had myocardial infarction and cardiomyopathies. CMR can improve diagnostic accuracy and evaluate subclinical cardiomyopathies.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Medicine, General & Internal
Gioia Piersanti, Giovanni Landoni, Tommaso Scquizzato, Alberto Zangrillo, Lorenzo Piemonti
Summary: A meta-analysis of nine studies involving 733 patients showed that the anti-inflammatory drug Reparixin improved survival in critically ill or transplant patients (including both COVID-19 and non-COVID-19 patients) without increasing the risk of infection.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Francesco Piroli, Antonio Boccellino, Giacomo Ingallina, Marco Rolando, Francesco Melillo, Francesco Ancona, Stefano Stella, Federico Biondi, Anna Palmisano, Antonio Esposito, Paolo Denti, Matteo Montorfano, Francesco Maisano, Alessandro Castiglioni, Eustachio Agricola
Summary: This study evaluated the feasibility and reliability of comprehensive 3D-TOE screening in TMVR candidates. The results showed that 3D-TOE measurements were highly correlated with CT measurements and accurately predicted TMVR screening success.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Davide Vignale, Anna Palmisano, Chiara Gnasso, Davide Margonato, Davide Romagnolo, Simone Barbieri, Giacomo Ingallina, Stefano Stella, Marco Bruno Ancona, Matteo Montorfano, Francesco Maisano, Eustachio Agricola, Antonio Esposito
Summary: The prognostic value of the interstitial fibrosis marker ECV measured at planning CT before TAVI was assessed. The study found that ECV higher than 31.3% was associated with an increased risk of heart failure hospitalization or death.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Giulia Grazzini, Silvia Pradella, Alice Rossi, Rocco Pio Basile, Matteo Ruggieri, Daniele Galli, Anna Palmisano, Pierpaolo Palumbo, Antonio Esposito, Vittorio Miele
Summary: It is important to evaluate and characterize cardiac masses using non-invasive imaging methods following their accidental discovery during an echocardiographic examination. Echocardiography, CT, CMR, and PET are the main imaging modalities used for their evaluation. Among them, CMR is the best technique for non-invasive tissue characterization, aided by its different MR sequences. This article provides detailed descriptions of each CMR sequence employed in the evaluation of cardiac masses, offering useful guidance to radiologists.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Rheumatology
Giacomo De Luca, Corrado Campochiaro, Anna Palmisano, Elisa Bruno, Davide Vignale, Giovanni Peretto, Simone Sala, Arianna Ferlito, Maria Bernardette Cilona, Antonio Esposito, Marco Matucci-Cerinic, Lorenzo Dagna
Summary: Myocarditis is a common manifestation in patients with anti-synthetase syndrome (ASS), especially at the clinical onset. Patients with ASS myocarditis often present with fever and an inflammatory phenotype. The use of cardiac MRI (CMRI) mapping techniques can improve the diagnostic sensitivity for myocarditis in ASS.
Article
Oncology
Sabrina Gloria Giulia Testoni, Claudia Minici, Elisa Benetti, Francesca Clemente, Daniela Boselli, Clara Sciorati, Lucia De Monte, Maria Chiara Petrone, Markus Enderle, Walter Linzenbold, Maria Pia Protti, Angelo Manfredi, Francesco De Cobelli, Michele Reni, Massimo Falconi, Gabriele Capurso, Paolo Giorgio Arcidiacono, Emanuel Della-Torre
Summary: Thermal ablation under endoscopic ultrasound (EUS)-guidance has shown potential to enhance immune response in pancreatic ductal adenocarcinoma (PDAC). In a recent trial, EUS-guided ablation with HybridTherm Probe (HTP) in combination with chemotherapy improved disease progression compared to chemotherapy alone. This study explored the effects of EUS-HTP on systemic immune response in PDAC and found that it selectively affected immunological predictors of poor outcome.
Letter
Radiology, Nuclear Medicine & Medical Imaging
Davide Vignale, Anna Palmisano, Caterina Colantoni, Lisa Brunetti, Valeria Nicoletti, Chiara Gnasso, Antonio Esposito
Article
Cardiac & Cardiovascular Systems
Guido Ascione, Nicolo Azzola Guicciardi, Roberto Lorusso, Antonio Boccellino, Elisabetta Lapenna, Benedetto Del Forno, Davide Carino, Arturo Bisogno, Anna Palmisano, Giuseppe D'Angelo, Paolo Della Bella, Antonio Esposito, Eustachio Agricola, Ottavio Alfieri, Alessandro Castiglioni, Francesco Maisano, Pasquale Vergara, Michele De Bonis
Summary: The objective of this study was to evaluate the arrhythmic burden in patients with Barlow's disease and significant mitral regurgitation, and to assess the impact of mitral repair on ventricular arrhythmias. The study found that one-third of the patients had arrhythmic burden at baseline, and about half of them became arrhythmia-free after mitral surgery. However, a minority of patients without arrhythmic burden at baseline experienced significant ventricular arrhythmias at follow-up.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)