VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice

Brain‐derived neurotrophic factor fused with a collagen‐binding domain inhibits neuroinflammation and promotes neurological recovery of traumatic brain injury mice via TrkB signalling

(2020) Rui Yin et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells

(2019) Hui Shi et al.   MOLECULES

Tetramethylpyrazine ameliorates depression by inhibiting TLR4-NLRP3 inflammasome signal pathway in mice

(2019) Songnian Fu et al.   PSYCHOPHARMACOLOGY

The role of microglial inflammasome activation in pyroptotic cell death following penetrating traumatic brain injury

(2019) Stephanie W. Lee et al.   Journal of Neuroinflammation

HIV infection modulates IL‐1β response to LPS stimulation through a TLR4‐NLRP3 pathway in human liver macrophages

(2019) Lumin Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cardiovascular protective effect of pioglitazone on oxidative stress in rats with metabolic syndrome

(2019) Ayca Bilginoglu   Journal of the Chinese Medical Association

The extent of pyroptosis varies in different stages of apical periodontitis

(2018) Ran Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neuroprotective effect of docosahexaenoic acid in rat traumatic brain injury model via regulation of TLR4/NF-Kappa B signaling pathway

(2018) Ri Tang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inflammasome: Its role in traumatic brain and spinal cord injury

(2018) Keywan Mortezaee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo

(2018) Wei Liu et al.   Journal of Neuroinflammation

Microglial Inflammasome Activation in Penetrating Ballistic-Like Brain Injury

(2018) Stephanie W. Lee et al.   JOURNAL OF NEUROTRAUMA

Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury

(2018) Xin Xu et al.   NEUROBIOLOGY OF DISEASE

Isosteviol sodium injection improves outcomes by modulating TLRs/NF-κB-dependent inflammatory responses following experimental traumatic brain injury in rats

(2018) Jie Zan et al.   NEUROREPORT

Inflammasome biology, molecular pathology and therapeutic implications

(2018) Fawaz Awad et al.   PHARMACOLOGY & THERAPEUTICS

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction

(2018) Yam Nath Paudel et al.   Frontiers in Neuroscience

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Anti-inflammatory and immunomodulatory mechanisms of atorvastatin in a murine model of traumatic brain injury

(2017) Xin Xu et al.   Journal of Neuroinflammation

Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue

(2017) Zhenjiang Liu et al.   JOURNAL OF PINEAL RESEARCH

DRα1-MOG-35-55 treatment reduces lesion volumes and improves neurological deficits after traumatic brain injury

(2017) Liu Yang et al.   METABOLIC BRAIN DISEASE

Cordycepin confers neuroprotection in mice models of intracerebral hemorrhage via suppressing NLRP3 inflammasome activation

(2017) Yijun Cheng et al.   METABOLIC BRAIN DISEASE

Hyperbaric oxygen alleviates the activation of NLRP-3-inflammasomes in traumatic brain injury

(2017) Huihui Qian et al.   Molecular Medicine Reports

The far-reaching scope of neuroinflammation after traumatic brain injury

(2017) Dennis W. Simon et al.   Nature Reviews Neurology

Protective Role of Apocynin via Suppression of Neuronal Autophagy and TLR4/NF-κB Signaling Pathway in a Rat Model of Traumatic Brain Injury

(2017) Yan Feng et al.   NEUROCHEMICAL RESEARCH

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

(2017) Robin A. Aglietti et al.   TRENDS IN IMMUNOLOGY

Multimodal Imaging of Neurometabolic Pathology due to Traumatic Brain Injury

(2017) John Darrell Van Horn et al.   TRENDS IN NEUROSCIENCES

Resveratrol attenuates neuronal autophagy and inflammatory injury by inhibiting the TLR4/NF-κB signaling pathway in experimental traumatic brain injury

(2016) YAN FENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Posttraumatic therapeutic hypothermia alters microglial and macrophage polarization toward a beneficial phenotype

(2016) Jessie S Truettner et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury

(2016) Alok Kumar et al.   JOURNAL OF NEUROTRAUMA

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Inflammatory neuroprotection following traumatic brain injury

(2016) M. V. Russo et al.   SCIENCE

Emerging Roles for the Immune System in Traumatic Brain Injury

(2016) Celia A. McKee et al.   Frontiers in Immunology

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

(2016) Bin Ma et al.   Frontiers in Immunology

VEGI attenuates the inflammatory injury and disruption of blood–brain barrier partly by suppressing the TLR4/NF-κB signaling pathway in experimental traumatic brain injury

(2015) Weiwei Gao et al.   BRAIN RESEARCH

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

(2015) José A. García et al.   FASEB JOURNAL

NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation

(2015) Y. Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma

(2015) Wei Chi et al.   Journal of Neuroinflammation

bFGF Protects Against Blood-Brain Barrier Damage Through Junction Protein Regulation via PI3K-Akt-Rac1 Pathway Following Traumatic Brain Injury

(2015) Zhou-Guang Wang et al.   MOLECULAR NEUROBIOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Ethanol-Induced TLR4/NLRP3 Neuroinflammatory Response in Microglial Cells Promotes Leukocyte Infiltration Across the BBB

(2015) Silvia Alfonso-Loeches et al.   NEUROCHEMICAL RESEARCH

LncRNA BCAR4 wires up signaling transduction in breast cancer

(2015) Zhen Xing et al.   RNA Biology

The Blood–Brain Barrier as a Target in Traumatic Brain Injury Treatment

(2014) Serge C. Thal et al.   ARCHIVES OF MEDICAL RESEARCH

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Macrophagic and microglial responses after focal traumatic brain injury in the female rat

(2014) L Turtzo et al.   Journal of Neuroinflammation

Thioredoxin-Interacting Protein: a Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice

(2014) Tauheed Ishrat et al.   MOLECULAR NEUROBIOLOGY

miR-21 improves the neurological outcome after traumatic brain injury in rats

(2014) Xin-Tong Ge et al.   Scientific Reports

Caspase-1: The inflammasome and beyond

(2013) Gabriel Sollberger et al.   Innate Immunity

Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury

(2013) Guohua Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and Reperfusion

(2013) Ying Wang et al.   MEDIATORS OF INFLAMMATION

Pyroptosis: An inflammatory cell death implicates in atherosclerosis

(2013) Wei Chang et al.   MEDICAL HYPOTHESES

Hyperbaric Oxygen Alleviates Experimental (Spinal Cord) Injury by Downregulating HMGB1/NF-κB Expression

(2013) Jing Yang et al.   SPINE

The Role of Markers of Inflammation in Traumatic Brain Injury

(2013) Thomas Woodcock et al.   Frontiers in Neurology

Incidence of traumatic brain injury in New Zealand: a population-based study

(2012) Valery L Feigin et al.   LANCET NEUROLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats

(2011) Jin-bing Zhao et al.   NEUROSCIENCE LETTERS

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutively Active Inflammasome in Human Melanoma Cells Mediating Autoinflammation via Caspase-1 Processing and Secretion of Interleukin-1β

(2009) Miyako Okamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY