Advances and gaps in SARS-CoV-2 infection models

SARS-CoV-2 spike D614G change enhances replication and transmission

(2021) Bin Zhou et al.   NATURE

BNT162b vaccines protect rhesus macaques from SARS-CoV-2

(2021) Annette B. Vogel et al.   NATURE

Vaccine-associated enhanced disease: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data

(2021) Flor M. Munoz et al.   VACCINE

Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19

(2021) Francisco J. Salguero et al.   Nature Communications

SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates

(2021) Nikolaos C. Kyriakidis et al.   npj Vaccines

COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters

(2021) Guilherme Dias de Melo et al.   Science Translational Medicine

Vascular Inflammation Is Associated with Loss of Aquaporin 1 Expression on Endothelial Cells and Increased Fluid Leakage in SARS-CoV-2 Infected Golden Syrian Hamsters

(2021) Lisa Allnoch et al.   Viruses-Basel

Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model

(2021) Kyle Rosenke et al.   Nature Communications

Covid vaccine could be rolled out to children by autumn

(2021) Elisabeth Mahase   BMJ-British Medical Journal

Vasculitis and Neutrophil Extracellular Traps in Lungs of Golden Syrian Hamsters With SARS-CoV-2

(2021) Kathrin Becker et al.   Frontiers in Immunology

Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice

(2021) Kun Huang et al.   EBioMedicine

ChAdOx1 nCoV-19 (AZD1222) vaccine candidate significantly reduces SARS-CoV-2 shedding in ferrets

(2021) Glenn A. Marsh et al.   npj Vaccines

Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species

(2021) Ruoke Wang et al.   IMMUNITY

Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques

(2021) Jingyou Yu et al.   NATURE

SARS-CoV-2 Variants and Vaccines

(2021) Philip R. Krause et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prior infection with SARS-CoV-2 WA1/2020 partially protects rhesus macaques against re-infection with B.1.1.7 and B.1.351 variants

(2021) Abishek Chandrashekar et al.   Science Translational Medicine

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models

(2021) Neeltje van Doremalen et al.   Science Translational Medicine

SARS-CoV-2 Delta Variant Pathogenesis and Host Response in Syrian Hamsters

(2021) Sreelekshmy Mohandas et al.   Viruses-Basel

Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model

(2021) Santosh Dhakal et al.   mBio

CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

(2021) Donata Hoffmann et al.   Nature Communications

A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

(2021) Jiandong Huo et al.   Nature Communications

A highly potent antibody effective against SARS-CoV-2 variants of concern

(2021) Craig Fenwick et al.   Cell Reports

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

(2021) Ahmed O. Hassan et al.   Cell Reports

Immunological and pathological outcomes of SARS-CoV-2 challenge following formalin-inactivated vaccine in ferrets and rhesus macaques

(2021) Kevin R. Bewley et al.   Science Advances

Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters

(2021) Rana Abdelnabi et al.   EBioMedicine

Early cross-coronavirus reactive signatures of humoral immunity against COVID-19

(2021) Paulina Kaplonek et al.   Science Immunology

Predictive Value of Precision-Cut Lung Slices for the Susceptibility of Three Animal Species for SARS-CoV-2 and Validation in a Refined Hamster Model

(2021) Nora M. Gerhards et al.   Pathogens

COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models

(2021) Pauline Maisonnasse et al.   Nature Communications

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

(2021) Britton Boras et al.   Nature Communications

Nasal delivery of single-domain antibody improves symptoms of SARS-CoV-2 infection in an animal model

(2021) Kei Haga et al.   PLoS Pathogens

Structure-guided antibody cocktail for prevention and treatment of COVID-19

(2021) Shih-Chieh Su et al.   PLoS Pathogens

Generation and Effect Testing of a SARS-CoV-2 RBD-Targeted Polyclonal Therapeutic Antibody Based on a 2-D Airway Organoid Screening System

(2021) Yunjiao He et al.   Frontiers in Immunology

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

(2020) Tran Thi Nhu Thao et al.   NATURE

Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model

(2020) Barry Rockx et al.   SCIENCE

COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives

(2020) Masataka Nishiga et al.   Nature Reviews Cardiology

Age-Dependent Progression of SARS-CoV-2 Infection in Syrian Hamsters

(2020) Nikolaus Osterrieder et al.   Viruses-Basel

A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology

(2020) Andrew Rambaut et al.   Nature Microbiology

In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2

(2020) Andrés Pizzorno et al.   ANTIVIRAL RESEARCH

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

(2020) Sarah R. Leist et al.   CELL

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

(2020) Carolyn Rydyznski Moderbacher et al.   CELL

Animal models for COVID-19

(2020) César Muñoz-Fontela et al.   NATURE

Sex differences in immune responses that underlie COVID-19 disease outcomes

(2020) Takehiro Takahashi et al.   NATURE

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

(2020) Emma S. Winkler et al.   NATURE IMMUNOLOGY

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity

(2020) Suzanne J. F. Kaptein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients

(2020) S. G. P. Funnell et al.   Nature Communications

Correlates of protection against SARS-CoV-2 in rhesus macaques

(2020) Katherine McMahan et al.   NATURE

Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets

(2020) Dhiraj Kumar Singh et al.   Nature Microbiology

Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets

(2020) Robert M. Cox et al.   Nature Microbiology

Acute Respiratory Distress in Aged, SARS-CoV-2–Infected African Green Monkeys but Not Rhesus Macaques

(2020) Robert V. Blair et al.   AMERICAN JOURNAL OF PATHOLOGY

Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques

(2020) Hirohito Ishigaki et al.   VIROLOGY

Critical role of phospholipase A2group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection

(2015) Rahul Vijay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

(2012) Chien-Te Tseng et al.   PLoS One

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

(2011) M. Bolles et al.   JOURNAL OF VIROLOGY

SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism

(2010) Matthew B. Frieman et al.   PLoS Pathogens