Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection

The Trigeminovascular Pathway: Role of CGRP and CGRP Receptors in Migraine

(2017) Lars Edvinsson   HEADACHE

The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies

(2017) Aziz Bousfiha et al.   JOURNAL OF CLINICAL IMMUNOLOGY

International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity

(2017) Capucine Picard et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease

(2016) Julius A. Steinbeck et al.   Cell Stem Cell

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

(2016) Faranak Fattahi et al.   NATURE

Two Modes of the Axonal Interferon Response Limit Alphaherpesvirus Neuroinvasion

(2016) Ren Song et al.   mBio

Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants

(2016) Lisa Hoelting et al.   Stem Cells Translational Medicine

Derivation of Diverse Hormone-Releasing Pituitary Cells from Human Pluripotent Stem Cells

(2016) Bastian Zimmer et al.   Stem Cell Reports

Functional IRF3 deficiency in a patient with herpes simplex encephalitis

(2015) Line Lykke Andersen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation

(2015) Elizabeth L. Calder et al.   JOURNAL OF NEUROSCIENCE

Dynamic ubiquitination drives herpesvirus neuroinvasion

(2015) Nicholas J. Huffmaster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deciphering Human Cell-Autonomous Anti-HSV-1 Immunity in the Central Nervous System

(2015) Fabien G. Lafaille et al.   Frontiers in Immunology

Intrinsic Innate Immunity Fails To Control Herpes Simplex Virus and Vesicular Stomatitis Virus Replication in Sensory Neurons and Fibroblasts

(2014) P. C. Rosato et al.   JOURNAL OF VIROLOGY

Selective conversion of fibroblasts into peripheral sensory neurons

(2014) Joel W Blanchard et al.   NATURE NEUROSCIENCE

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts

(2014) Brian J Wainger et al.   NATURE NEUROSCIENCE

TLR3 deficiency in herpes simplex encephalitis: High allelic heterogeneity and recurrence risk

(2014) H. K. Lim et al.   NEUROLOGY

Reprogrammed Cells for Disease Modeling and Regenerative Medicine

(2013) Anne B.C. Cherry et al.   Annual Review of Medicine

An Inquiry into the Molecular Basis of HSV Latency and Reactivation

(2013) Bernard Roizman et al.   Annual Review of Microbiology

TLR3 immunity to infection in mice and humans

(2013) Shen-Ying Zhang et al.   CURRENT OPINION IN IMMUNOLOGY

Specification of Functional Cranial Placode Derivatives from Human Pluripotent Stem Cells

(2013) Zehra Dincer et al.   Cell Reports

Herpesvirus Transport to the Nervous System and Back Again

(2012) Gregory Smith   Annual Review of Microbiology

Neural Induction and Patterning in Mammalian Pluripotent Stem Cells

(2012) Fumitaka Osakada et al.   CNS & Neurological Disorders-Drug Targets

HeterozygousTBK1mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood

(2012) Melina Herman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

(2012) Fabien G. Lafaille et al.   NATURE

Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

(2012) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

(2011) Vanessa Sancho-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

(2011) Yiqi Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell-Surface Marker Signatures for the Isolation of Neural Stem Cells, Glia and Neurons Derived from Human Pluripotent Stem Cells

(2011) Shauna H. Yuan et al.   PLoS One

Birth of ophthalmic trigeminal neurons initiates early in the placodal ectoderm

(2009) Kathryn L. McCabe et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Host strain-dependent difference in susceptibility in a rat model of herpes simplex type 1 encephalitis

(2008) Biborka Bereczky-Veress et al.   JOURNAL OF NEUROVIROLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols