Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase

(2017) Aiping Bai et al.   PLoS One

Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death

(2016) K. Sundaram et al.   BIOCHEMICAL JOURNAL

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in Cancer Cells Is Independent of the Adenine Nucleotide Translocator

(2016) Eduardo N. Maldonado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Glutamate signalling: A multifaceted modulator of oligodendrocyte lineage cells in health and disease

(2016) Sonia Spitzer et al.   NEUROPHARMACOLOGY

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

(2016) Angela V. Hafner et al.   Aging-US

NADPH Oxidase-2: Linking Glucose, Acidosis, and Excitotoxicity in Stroke

(2015) Angela M. Brennan-Minnella et al.   ANTIOXIDANTS & REDOX SIGNALING

Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases

(2015) Olga Gorelenkova Miller et al.   ARCHIVES OF TOXICOLOGY

Glutamate and GABA Imbalance Following Traumatic Brain Injury

(2015) Réjean M. Guerriero et al.   Current Neurology and Neuroscience Reports

SIRT3 Deacetylates Ceramide Synthases

(2015) Sergei A. Novgorodov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection

(2015) Paolo Bernardi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Essential Roles of Neutral Ceramidase and Sphingosine in Mitochondrial Dysfunction Due to Traumatic Brain Injury

(2014) Sergei A. Novgorodov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Die another way – non-apoptotic mechanisms of cell death

(2014) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer’s disease

(2014) Jong Kil Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons

(2014) Nadine Beckmann et al.   Frontiers in Physiology

Glutathione Depletion by L-Buthionine-S,R-Sulfoximine Induces Apoptosis of Cardiomyocytes through Activation of PKC-δ

(2013) Young-Ae Kim et al.   Biomolecules & Therapeutics

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Ablation of Ceramide Synthase 2 Causes Chronic Oxidative Stress Due to Disruption of the Mitochondrial Respiratory Chain

(2013) Hila Zigdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

(2013) Erich Gulbins et al.   NATURE MEDICINE

Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration

(2013) Brad Kincaid et al.   Frontiers in Aging Neuroscience

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase

(2012) A Degterev et al.   CELL DEATH AND DIFFERENTIATION

Oxidative Stress Triggers Ca2+-Dependent Lysosome Trafficking and Activation of Acid Sphingomyelinase

(2012) Xiang Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mechanisms of Oxidative Glutamate Toxicity: The Glutamate/Cystine Antiporter System xc¯ as a Neuroprotective Drug Target

(2012) Philipp Albrecht et al.   CNS & Neurological Disorders-Drug Targets

Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons

(2012) Terina N Martinez et al.   Molecular Neurodegeneration

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases

(2011) Daniel Canals et al.   BRITISH JOURNAL OF PHARMACOLOGY

System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

(2011) Richard J Bridges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Protein S-glutathiolation: Redox-sensitive regulation of protein function

(2011) Bradford G. Hill et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity

(2011) Lydia W. S. Finley et al.   PLoS One

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications

(2010) Johannes Kornhuber et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ceramide-rich platforms in transmembrane signaling

(2010) Branka Stancevic et al.   FEBS LETTERS

A Novel Mechanism of Lysosomal Acid Sphingomyelinase Maturation

(2010) Russell W. Jenkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Developmentally Regulated Ceramide Synthase 6 Increases Mitochondrial Ca2+Loading Capacity and Promotes Apoptosis

(2010) Sergei A. Novgorodov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair

(2010) Christina Tam et al.   JOURNAL OF CELL BIOLOGY

Quantitative Microplate-Based Respirometry with Correction for Oxygen Diffusion

(2009) Akos A. Gerencser et al.   ANALYTICAL CHEMISTRY

Potent and Selective Inhibition of Acid Sphingomyelinase by Bisphosphonates

(2009) Anke G. Roth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oligodendroglial impact on axonal function and survival – a hypothesis

(2009) Celia Michèle Kassmann et al.   CURRENT OPINION IN NEUROLOGY

Cyclophilin D Modulates Mitochondrial F0F1-ATP Synthase by Interacting with the Lateral Stalk of the Complex

(2009) Valentina Giorgio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sphingolipid salvage pathway in ceramide metabolism and signaling

(2008) Kazuyuki Kitatani et al.   CELLULAR SIGNALLING

Integrin-associated Lyn Kinase Promotes Cell Survival by Suppressing Acid Sphingomyelinase Activity

(2008) Daria A. Chudakova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuroprotection for ischemic stroke: Past, present and future

(2008) Myron D. Ginsberg   NEUROPHARMACOLOGY

A novel role for protein kinase Cδ-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury

(2007) Youssef H. Zeidan et al.   FASEB JOURNAL