- Home
- Publications
- Publication Search
- Publication Details
Title
Microglial metabolic flexibility: emerging roles for lactate
Authors
Keywords
lactate, metabolism, microglia, synaptic function, CNS disease
Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 33, Issue 3, Pages 186-195
Publisher
Elsevier BV
Online
2022-01-05
DOI
10.1016/j.tem.2021.12.001
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF
- (2021) Federica Buffolo et al. Cell Death & Disease
- TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease
- (2021) Jia Lu et al. EMBO REPORTS
- Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system
- (2021) Sheng Yang et al. NEUROBIOLOGY OF DISEASE
- Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia
- (2021) Jana Krystofova Mike et al. Cells
- Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury
- (2020) Arif Yurdagul et al. Cell Metabolism
- Glioblastoma hijacks microglial gene expression to support tumor growth
- (2020) Sybren L. N. Maas et al. Journal of Neuroinflammation
- Microglial metabolic flexibility supports immune surveillance of the brain parenchyma
- (2020) Louis-Philippe Bernier et al. Nature Communications
- A Novel, Multi-Faceted Perception of Lactate in Neurology
- (2020) Shayne Mason Frontiers in Neuroscience
- Lactate dehydrogenase expression modulates longevity and neurodegeneration in Drosophila melanogaster
- (2020) Dani M. Long et al. Aging-US
- Functions of lactate in the brain of rat with intracerebral hemorrhage evaluated with MRI/MRS and in vitro approaches
- (2020) Yue Liu et al. CNS Neuroscience & Therapeutics
- Neuronal and astroglial monocarboxylate transporters play key but distinct roles in hippocampus-dependent learning and memory formation
- (2020) Citlalli Netzahualcoyotzi et al. PROGRESS IN NEUROBIOLOGY
- Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling
- (2020) Kun Yang et al. Frontiers in Immunology
- Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo
- (2019) Syam Nair et al. GLIA
- Involvement of lactate transport in two object recognition tasks that require either the hippocampus or striatum.
- (2019) Donna L. Korol et al. BEHAVIORAL NEUROSCIENCE
- Unappreciated Role of LDHA and LDHB to Control Apoptosis and Autophagy in Tumor Cells
- (2019) Kaja Urbańska et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Dual Functions of Microglia in Ischemic Stroke
- (2019) Chuan Qin et al. Neuroscience Bulletin
- A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease
- (2019) Sung Hoon Baik et al. Cell Metabolism
- Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling
- (2019) Arnaud Tauffenberger et al. Cell Death & Disease
- Monocarboxylate transporter 1 promotes classical microglial activation and pro-inflammatory effect via 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3
- (2019) Liang Kong et al. Journal of Neuroinflammation
- Metabolic regulation of gene expression by histone lactylation
- (2019) Di Zhang et al. NATURE
- Can the emerging field of immunometabolism provide insights into neuroinflammation?
- (2019) Marina A. Lynch PROGRESS IN NEUROBIOLOGY
- Cien Años de Microglía: Milestones in a Century of Microglial Research
- (2019) Amanda Sierra et al. TRENDS IN NEUROSCIENCES
- Versatility of microglial bioenergetic machinery under starving conditions
- (2018) Adam M. Nagy et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Lactate metabolism: historical context, prior misinterpretations, and current understanding
- (2018) Brian S. Ferguson et al. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
- Lactate in the brain: from metabolic end-product to signalling molecule
- (2018) Pierre J. Magistretti et al. NATURE REVIEWS NEUROSCIENCE
- Age related rise in lactate and its correlation with lactate dehydrogenase (LDH) status in post-mitochondrial fractions isolated from different regions of brain in mice
- (2018) Siddhartha Datta et al. NEUROCHEMISTRY INTERNATIONAL
- Microglia in neurodegeneration
- (2018) Suzanne Hickman et al. NATURE NEUROSCIENCE
- Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection
- (2018) P. Jourdain et al. Scientific Reports
- Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes
- (2018) Timothy R. Hammond et al. IMMUNITY
- Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage
- (2018) Mao Zhang et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Brain Glucose Metabolism: Integration of Energetics with Function
- (2018) Gerald A. Dienel PHYSIOLOGICAL REVIEWS
- Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity
- (2017) Richa Hanamsagar et al. GLIA
- An environment-dependent transcriptional network specifies human microglia identity
- (2017) David Gosselin et al. SCIENCE
- Macrophage Immunometabolism: Where Are We (Going)?
- (2017) Jan Van den Bossche et al. TRENDS IN IMMUNOLOGY
- Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer
- (2016) Lucie Brisson et al. CANCER CELL
- Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis
- (2016) Camille Lehuédé et al. CANCER RESEARCH
- Uniform distributions of glucose oxidation and oxygen extraction in gray matter of normal human brain: No evidence of regional differences of aerobic glycolysis
- (2016) Fahmeed Hyder et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Normal lactate concentration range in the neonatal brain
- (2016) Moyoko Tomiyasu et al. MAGNETIC RESONANCE IMAGING
- New tools for studying microglia in the mouse and human CNS
- (2016) Mariko L. Bennett et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade
- (2016) P. Jourdain et al. Scientific Reports
- The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia
- (2016) Kimberle Shen et al. Cell Reports
- Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner
- (2016) Agustina Errea et al. PLoS One
- Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization
- (2015) Abhishek K. Jha et al. IMMUNITY
- Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression
- (2015) Johannes Meiser et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Functional differences between microglia and monocytes after ischemic stroke
- (2015) Rodney M. Ritzel et al. Journal of Neuroinflammation
- Lactate is always the end product of glycolysis
- (2015) Matthew J. Rogatzki et al. Frontiers in Neuroscience
- Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions
- (2014) Philip G. Nijland et al. GLIA
- Metabolic Reprogramming of Macrophages
- (2014) Alex J. Freemerman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
- (2014) Y. Zhang et al. JOURNAL OF NEUROSCIENCE
- Glucose pathways adaptation supports acquisition of activated microglia phenotype
- (2014) J. Gimeno-Bayón et al. JOURNAL OF NEUROSCIENCE RESEARCH
- A hypothetical astrocyte–microglia lactate shuttle derived from a 1H NMR metabolomics analysis of cerebrospinal fluid from a cohort of South African children with tuberculous meningitis
- (2014) Shayne Mason et al. Metabolomics
- Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
- (2014) Oscar R. Colegio et al. NATURE
- Microglial CR3 Activation Triggers Long-Term Synaptic Depression in the Hippocampus via NADPH Oxidase
- (2014) Jingfei Zhang et al. NEURON
- Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin
- (2013) Ludmila A. Voloboueva et al. FEBS LETTERS
- ROS production in phagocytes: why, when, and where?
- (2013) Sophie Dupré-Crochet et al. JOURNAL OF LEUKOCYTE BIOLOGY
- The SLC16 gene family – Structure, role and regulation in health and disease
- (2013) Andrew P. Halestrap MOLECULAR ASPECTS OF MEDICINE
- Neuroprotective effects of lactate in brain ischemia: Dependence on anesthetic drugs
- (2013) Tobias Horn et al. NEUROCHEMISTRY INTERNATIONAL
- Catabolism of Exogenous Lactate Reveals It as a Legitimate Metabolic Substrate in Breast Cancer
- (2013) Kelly M. Kennedy et al. PLoS One
- Early Decline in Glucose Transport and Metabolism Precedes Shift to Ketogenic System in Female Aging and Alzheimer's Mouse Brain: Implication for Bioenergetic Intervention
- (2013) Fan Ding et al. PLoS One
- New Evidence of Neuroprotection by Lactate after Transient Focal Cerebral Ischaemia: Extended Benefit after Intracerebroventricular Injection and Efficacy of Intravenous Administration
- (2012) Carole Berthet et al. CEREBROVASCULAR DISEASES
- Mechanisms of triglyceride accumulation in activated macrophages
- (2012) Kenneth R. Feingold et al. JOURNAL OF LEUKOCYTE BIOLOGY
- The Neuroprotective Effect of Lactate Is Not Due to Improved Glutamate Uptake after Controlled Cortical Impact in Rats
- (2012) Beat Alessandri et al. JOURNAL OF NEUROTRAUMA
- Oligodendroglia metabolically support axons and contribute to neurodegeneration
- (2012) Youngjin Lee et al. NATURE
- An Abundant Tissue Macrophage Population in the Adult Murine Heart with a Distinct Alternatively-Activated Macrophage Profile
- (2012) Alexander R. Pinto et al. PLoS One
- Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
- (2011) Akinobu Suzuki et al. CELL
- Regulation of Oligodendrocyte Development and Myelination by Glucose and Lactate
- (2011) J. E. Rinholm et al. JOURNAL OF NEUROSCIENCE
- CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity
- (2011) J. T. Rogers et al. JOURNAL OF NEUROSCIENCE
- Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing
- (2011) Lori A. Newman et al. PLoS One
- Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
- (2011) R. C. Paolicelli et al. SCIENCE
- High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio
- (2010) J. M. Ross et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enhanced Cerebral Expression of MCT1 and MCT2 in a Rat Ischemia Model Occurs in Activated Microglial Cells
- (2009) Tiago JTP Moreira et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Cell-cell and intracellular lactate shuttles
- (2009) George A. Brooks JOURNAL OF PHYSIOLOGY-LONDON
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now