Label-free and homogeneous detection of flap endonuclease 1 by ligation-promoted hyperbranched rolling circle amplification platform

Dual-Mode FEN1 Activity Detection Based on Nt.BstNBI-Induced Tandem Signal Amplification

(2021) Haitang Yang et al.   ANALYTICAL CHEMISTRY

Simple Mix-and-Read Assay with Multiple Cyclic Enzymatic Repairing Amplification for Rapid and Sensitive Detection of DNA Glycosylase

(2021) Juan Hu et al.   ANALYTICAL CHEMISTRY

Hairpin DNA-Mediated isothermal amplification (HDMIA) techniques for nucleic acid testing

(2021) Idorenyin A. Iwe et al.   TALANTA

Lab in a tube: Isolation, extraction, and isothermal amplification detection of exosomal long noncoding RNA of gastric cancer

(2021) Qiuyuan Lin et al.   TALANTA

Precision Spherical Nucleic Acids Enable Sensitive FEN1 Imaging and Controllable Drug Delivery for Cancer-Specific Therapy

(2021) Shuang Li et al.   ANALYTICAL CHEMISTRY

Photothermal mediated rolling circle amplification toward specific and direct in situ mRNA detection

(2021) Dongdong Liu et al.   BIOSENSORS & BIOELECTRONICS

Combination of bidirectional strand displacement amplification with single-molecule detection for multiplexed DNA glycosylases assay

(2021) Yan Zhang et al.   TALANTA

Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma

(2020) Yingying Zhang et al.   DISEASE MARKERS

Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer

(2020) Koen D. Flach et al.   CANCER RESEARCH

Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation

(2020) Lei Wei et al.   Nature Microbiology

FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination

(2020) Elaine Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hybridization-based in situ sequencing (HybISS) for spatially resolved transcriptomics in human and mouse brain tissue

(2020) Daniel Gyllborg et al.   NUCLEIC ACIDS RESEARCH

Construction of a sensitive protease sensor with DNA-peptide conjugates for single-molecule detection of multiple matrix metalloproteinases

(2020) Yueying Li et al.   BIOSENSORS & BIOELECTRONICS

Enzyme-free electrochemical biosensor based on amplification of proximity-dependent surface hybridization chain reaction for ultrasensitive mRNA detection

(2020) Yu-Hong Cheng et al.   TALANTA

A trifunctional split dumbbell probe coupled with ligation-triggered isothermal rolling circle amplification for label-free and sensitive detection of nicotinamide adenine dinucleotide

(2020) Ya-ru Meng et al.   TALANTA

Discovery of Myricetin as a Potent Inhibitor of Human Flap Endonuclease 1, Which Potentially Can Be Used as Sensitizing Agent against HT-29 Human Colon Cancer Cells

(2019) Long Ma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

RNA Strand Displacement Responsive CRISPR/Cas9 System for mRNA Sensing

(2019) Yue Li et al.   ANALYTICAL CHEMISTRY

MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer

(2019) Xiao Lu et al.   ONCOGENE

On-chip RT-LAMP and colorimetric detection of the prostate cancer 3 biomarker with an integrated thermal and imaging box

(2019) Lin-Xiang Wang et al.   TALANTA

A terminal extension-actuated isothermal exponential amplification strategy toward the ultrasensitive and versatile detection of enzyme activity in a single cell

(2019) Weimin Tian et al.   TALANTA

Overexpression of Flap Endonuclease 1 Correlates with Enhanced Proliferation and Poor Prognosis of Non–Small-Cell Lung Cancer

(2018) Keqiang Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Missed cleavage opportunities by FEN1 lead to Okazaki fragment maturation via the long-flap pathway

(2018) Manal S Zaher et al.   NUCLEIC ACIDS RESEARCH

Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus

(2018) Kouichi Kitamura et al.   PLoS Pathogens

An electrochemical biosensor based on the enhanced quasi-reversible redox signal of prussian blue generated by self-sacrificial label of iron metal-organic framework

(2018) Lin Cui et al.   BIOSENSORS & BIOELECTRONICS

Versatile Types of DNA-Based Nanobiosensors for Specific Detection of Cancer Biomarker FEN1 in Living Cells and Cell-Free Systems

(2018) Hao Zhang et al.   NANO LETTERS

FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer

(2017) Lingfeng He et al.   Molecular Oncology

Control of structure-specific endonucleases to maintain genome stability

(2017) Pierre-Marie Dehé et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Resolving individual steps of Okazaki-fragment maturation at a millisecond timescale

(2016) Joseph L Stodola et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Replication stress: getting back on track

(2016) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Resolving individual steps of Okazaki-fragment maturation at a millisecond timescale

(2016) Joseph L Stodola et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Replication stress: getting back on track

(2016) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression

(2016) Lingfeng He et al.   EBioMedicine

Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell proliferation and apoptosis

(2014) KEJIA WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

(2014) Tarek M.A. Abdel-Fatah et al.   Molecular Oncology

FEN1 Ensures Telomere Stability by Facilitating Replication Fork Re-initiation

(2010) Abhishek Saharia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity

(2010) Dorjbal Dorjsuren et al.   NUCLEIC ACIDS RESEARCH

Interaction of aurintricarboxylic acid (ATA) with four nucleic acid binding proteins DNase I, RNase A, reverse transcriptase and Taq polymerase

(2009) Utpal Ghosh et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Flap Endonuclease 1 Contributes to Telomere Stability

(2008) Abhishek Saharia et al.   CURRENT BIOLOGY

Nucleolar Localization and Dynamic Roles of Flap Endonuclease 1 in Ribosomal DNA Replication and Damage Repair

(2008) Z. Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

Loop-mediated isothermal amplification (LAMP) of gene sequences and simple visual detection of products

(2008) Norihiro Tomita et al.   Nature Protocols