Architecturally complex O-glycopeptidases are customized for mucin recognition and hydrolysis

Two putative zinc metalloproteases contribute to the virulence of Clostridium perfringens strains that cause avian necrotic enteritis

(2020) Ben Wade et al.   JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION

Mucins and the Microbiome

(2020) Gunnar C. Hansson   Annual Review of Biochemistry

An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins

(2020) D. Judy Shon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Glycoprotease CpaA Secreted by Medically Relevant Acinetobacter Species Targets Multiple O-Linked Host Glycoproteins

(2020) M. Florencia Haurat et al.   mBio

Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila

(2020) Beatriz Trastoy et al.   Nature Communications

The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins

(2019) Stacy A. Malaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The MUC5B mucin polymer is dominated by repeating structural motifs and its topology is regulated by calcium and pH

(2019) Gareth W. Hughes et al.   Scientific Reports

Deciphering Protein O-Glycosylation: Solid-Phase Chemoenzymatic Cleavage and Enrichment

(2018) Shuang Yang et al.   ANALYTICAL CHEMISTRY

Expression system for structural and functional studies of human glycosylation enzymes

(2017) Kelley W Moremen et al.   Nature Chemical Biology

Diverse modes of galacto-specific carbohydrate recognition by a family 31 glycoside hydrolase from Clostridium perfringens

(2017) Julie M. Grondin et al.   PLoS One

Recognition of protein-linked glycans as a determinant of peptidase activity

(2017) Ilit Noach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

(2016) Mahesh S. Desai et al.   CELL

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

Polysaccharide Degradation by the Intestinal Microbiota and Its Influence on Human Health and Disease

(2016) Darrell W. Cockburn et al.   JOURNAL OF MOLECULAR BIOLOGY

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Plasmid Characterization and Chromosome Analysis of Two netF+ Clostridium perfringens Isolates Associated with Foal and Canine Necrotizing Enteritis

(2016) Iman Mehdizadeh Gohari et al.   PLoS One

Automated refinement of macromolecular structures at low resolution using prior information

(2016) Oleg Kovalevskiy et al.   Acta Crystallographica Section D-Structural Biology

Twenty years of theMEROPSdatabase of proteolytic enzymes, their substrates and inhibitors

(2015) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Ambiguity assessment of small-angle scattering curves from monodisperse systems

(2015) Maxim V. Petoukhov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Prevalence of Clostridium perfringens , Clostridium perfringens enterotoxin and dysbiosis in fecal samples of dogs with diarrhea

(2014) Yasushi Minamoto et al.   VETERINARY MICROBIOLOGY

Advances in understanding the molecular basis of plant cell wall polysaccharide recognition by carbohydrate-binding modules

(2013) Harry J Gilbert et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Substrate Recognition and Hydrolysis by a Family 50exo-β-Agarase, Aga50D, from the Marine BacteriumSaccharophagus degradans

(2013) Benjamin Pluvinage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved low-resolution crystallographic refinement with Phenix and Rosetta

(2013) Frank DiMaio et al.   NATURE METHODS

Conformational Analysis of StrH, the Surface-Attached exo-β-d-N-Acetylglucosaminidase from Streptococcus pneumoniae

(2012) Benjamin Pluvinage et al.   JOURNAL OF MOLECULAR BIOLOGY

A Novel Extracellular Metallopeptidase Domain Shared by Animal Host-Associated Mutualistic and Pathogenic Microbes

(2012) Sirintra Nakjang et al.   PLoS One

Carbohydrate Recognition by an Architecturally Complex α-N-Acetylglucosaminidase from Clostridium perfringens

(2012) Elizabeth Ficko-Blean et al.   PLoS One

Structural Insight into the Bacterial Mucinase StcE Essential to Adhesion and Immune Evasion during Enterohemorrhagic E. coli Infection

(2012) Angel C.Y. Yu et al.   STRUCTURE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

(2011) Arren Bar-Even et al.   BIOCHEMISTRY

iMod: multipurpose normal mode analysis in internal coordinates

(2011) José Ramón Lopéz-Blanco et al.   BIOINFORMATICS

Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law

(2011) Robert P. Rambo et al.   BIOPOLYMERS

The Overall Architecture and Receptor Binding of Pneumococcal Carbohydrate-Antigen-Hydrolyzing Enzymes

(2011) Melanie A. Higgins et al.   JOURNAL OF MOLECULAR BIOLOGY

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

Experimental phasing withSHELXC/D/E: combining chain tracing with density modification

(2010) George M. Sheldrick   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

DAMMIF, a program for rapidab-initioshape determination in small-angle scattering

(2009) Daniel Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Divergent Modes of Glycan Recognition by a New Family of Carbohydrate-binding Modules

(2008) Katie J. Gregg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

(2008) Gerrit Langer et al.   Nature Protocols

Structural basis of Clostridium perfringens toxin complex formation

(2008) J. J. Adams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA