Glycan-metabolizing enzymes in microbe-host interactions: the Streptococcus pneumoniae paradigm

Structural characterization of the PTS IIA and IIB proteins associated with pneumococcal fucose utilization

(2017) Melanie A. Higgins et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural Basis for Regulation and Specificity of Fructooligosaccharide Import in Streptococcus pneumoniae

(2017) Simone Culurgioni et al.   STRUCTURE

A bacterial ABC transporter enables import of mammalian host glycosaminoglycans

(2017) Sayoko Oiki et al.   Scientific Reports

Deacetylation of sialic acid by esterases potentiates pneumococcal neuraminidase activity for mucin utilization, colonization and virulence

(2017) Hasan F. Kahya et al.   PLoS Pathogens

Molecular Characterization of N-glycan Degradation and Transport in Streptococcus pneumoniae and Its Contribution to Virulence

(2017) Melissa Robb et al.   PLoS Pathogens

Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity

(2017) Greiciely O. Andre et al.   Frontiers in Microbiology

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

The Interaction between Respiratory Pathogens and Mucus

(2016) Mark Zanin et al.   Cell Host & Microbe

Metabolic traits of pathogenic streptococci

(2016) Jörg Willenborg et al.   FEBS LETTERS

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization

(2016) Krystle A. Blanchette et al.   INFECTION AND IMMUNITY

Lectin-Glycan Interaction Network-Based Identification of Host Receptors of Microbial Pathogenic Adhesins

(2016) Francesco S. Ielasi et al.   mBio

Evidence and Role for Bacterial Mucin Degradation in Cystic Fibrosis Airway Disease

(2016) Jeffrey M. Flynn et al.   PLoS Pathogens

Surface Proteoglycans as Mediators in Bacterial Pathogens Infections

(2016) Beatriz García et al.   Frontiers in Microbiology

Sequence diversity of NanA manifests in distinct enzyme kinetics and inhibitor susceptibility

(2016) Zhongli Xu et al.   Scientific Reports

Salmonella Degrades the Host Glycocalyx Leading to Altered Infection and Glycan Remodeling

(2016) Narine Arabyan et al.   Scientific Reports

Blood Groups in Infection and Host Susceptibility

(2015) Laura Cooling   CLINICAL MICROBIOLOGY REVIEWS

Metabolic Fate of Unsaturated Glucuronic/Iduronic Acids from Glycosaminoglycans

(2015) Yukie Maruyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Analysis of a Family 101 Glycoside Hydrolase in Complex with Carbohydrates Reveals Insights into Its Mechanism

(2015) Katie J. Gregg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Second β-Hexosaminidase Encoded in theStreptococcus pneumoniaeGenome Provides an Expanded Biochemical Ability to Degrade Host Glycans

(2015) Melissa Robb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Streptococcus pneumoniaeNanC

(2015) C. David Owen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fucose-Mediated Transcriptional Activation of the fcs Operon by FcsR in Streptococcus pneumoniae

(2015) Irfan Manzoor et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism

(2015) Fiona Cuskin et al.   NATURE

Structural characterization of the carbohydrate-binding module of NanA sialidase, a pneumococcal virulence factor

(2015) Lei Yang et al.   BMC STRUCTURAL BIOLOGY

Mucin glycan foraging in the human gut microbiome

(2015) Louise E. Tailford et al.   Frontiers in Genetics

Host Glycan Sugar-Specific Pathways in Streptococcus pneumonia: Galactose as a Key Sugar in Colonisation and Infection

(2015) Laura Paixão et al.   PLoS One

Conformational Analysis of theStreptococcus pneumoniaeHyaluronate Lyase and Characterization of Its Hyaluronan-specific Carbohydrate-binding Module

(2014) Michael D. L. Suits et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient utilization of complex N-linked glycans is a selective advantage for Bacteroides fragilis in extraintestinal infections

(2014) Y. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevention of influenza by targeting host receptors using engineered proteins

(2014) H. Connaris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unravelling the Multiple Functions of the Architecturally Intricate Streptococcus pneumoniae β-galactosidase, BgaA

(2014) Anirudh K. Singh et al.   PLoS Pathogens

Advances in understanding the molecular basis of plant cell wall polysaccharide recognition by carbohydrate-binding modules

(2013) Harry J Gilbert et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural Insights into the Substrate Specificity of a 6-Phospho-β-glucosidase BglA-2 fromStreptococcus pneumoniaeTIGR4

(2013) Wei-Li Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Analysis of Fucose-Processing Enzymes from Streptococcus pneumoniae

(2013) Melanie A. Higgins et al.   JOURNAL OF MOLECULAR BIOLOGY

The carbohydrate-active enzymes database (CAZy) in 2013

(2013) Vincent Lombard et al.   NUCLEIC ACIDS RESEARCH

Inhibition of the family 20 glycoside hydrolase catalytic modules in the Streptococcus pneumoniae exo-β-d-N-acetylglucosaminidase, StrH

(2013) Benjamin Pluvinage et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Pneumococcus: Epidemiology, Microbiology, and Pathogenesis

(2013) B. Henriques-Normark et al.   Cold Spring Harbor Perspectives in Medicine

Glycomic Analysis of Human Respiratory Tract Tissues and Correlation with Influenza Virus Infection

(2013) Trevenan Walther et al.   PLoS Pathogens

Necrotizing pneumonia caused by nanC-carrying serotypes is associated with pneumococcal haemolytic uraemic syndrome in children

(2012) R.-P. Janapatla et al.   CLINICAL MICROBIOLOGY AND INFECTION

Insights into the recognition of the human glycome by microbial carbohydrate-binding modules

(2012) Elizabeth Ficko-Blean et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Streptococcus pneumoniae Can Utilize Multiple Sources of Hyaluronic Acid for Growth

(2012) Carolyn Marion et al.   INFECTION AND IMMUNITY

The ABC Transporter Encoded at the Pneumococcal Fructooligosaccharide Utilization Locus Determines the Ability To Utilize Long- and Short-Chain Fructooligosaccharides

(2012) C. M. Linke et al.   JOURNAL OF BACTERIOLOGY

Structural Insights into the Substrate Specificity ofStreptococcus pneumoniaeβ(1,3)-Galactosidase BgaC

(2012) Wang Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Analysis of StrH, the Surface-Attached exo-β-d-N-Acetylglucosaminidase from Streptococcus pneumoniae

(2012) Benjamin Pluvinage et al.   JOURNAL OF MOLECULAR BIOLOGY

Pneumococcal neuraminidase A: an essential upper airway colonization factor for Streptococcus pneumoniae

(2012) J.L. Brittan et al.   Molecular Oral Microbiology

Pneumococcal surface proteins: when the whole is greater than the sum of its parts

(2012) I. Pérez-Dorado et al.   Molecular Oral Microbiology

How glycan metabolism shapes the human gut microbiota

(2012) Nicole M. Koropatkin et al.   NATURE REVIEWS MICROBIOLOGY

A Functional Genomics Approach to Establish the Complement of Carbohydrate Transporters in Streptococcus pneumoniae

(2012) Alessandro Bidossi et al.   PLoS One

Pneumococcal carbohydrate transport: food for thought

(2012) Carolyn M. Buckwalter et al.   TRENDS IN MICROBIOLOGY

Leukocyte Inflammatory Responses Provoked by Pneumococcal Sialidase

(2012) Y.-C. Chang et al.   mBio

Increased Nasopharyngeal Bacterial Titers and Local Inflammation Facilitate Transmission of Streptococcus pneumoniae

(2012) K. R. Short et al.   mBio

Structural analysis of a putative family 32 carbohydrate-binding module from theStreptococcus pneumoniaeenzyme EndoD

(2011) D. Wade Abbott et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Structure of the fucose mutarotase fromStreptococcus pneumoniaein complex withL-fucose

(2011) Melanie A. Higgins et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Identification of an ATPase, MsmK, Which Energizes Multiple Carbohydrate ABC Transporters in Streptococcus pneumoniae

(2011) Carolyn Marion et al.   INFECTION AND IMMUNITY

Role of Dihydrolipoamide Dehydrogenase in Regulation of Raffinose Transport in Streptococcus pneumoniae

(2011) R. E. Tyx et al.   JOURNAL OF BACTERIOLOGY

Analysis of a New Family of Widely Distributed Metal-independent α-Mannosidases Provides Unique Insight into the Processing ofN-Linked Glycans

(2011) Katie J. Gregg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Overall Architecture and Receptor Binding of Pneumococcal Carbohydrate-Antigen-Hydrolyzing Enzymes

(2011) Melanie A. Higgins et al.   JOURNAL OF MOLECULAR BIOLOGY

ThreeStreptococcus pneumoniaeSialidases: Three Different Products

(2011) Guogang Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CelR-mediated activation of the cellobiose-utilization gene cluster in Streptococcus pneumoniae

(2011) S. Shafeeq et al.   MICROBIOLOGY-SGM

BgaA acts as an adhesin to mediate attachment of some pneumococcal strains to human epithelial cells

(2011) D. H. Limoli et al.   MICROBIOLOGY-SGM

The genome and surface proteome of Capnocytophaga canimorsus reveal a key role of glycan foraging systems in host glycoproteins deglycosylation

(2011) Pablo Manfredi et al.   MOLECULAR MICROBIOLOGY

Inhibition of the Pneumococcal Virulence Factor StrH and Molecular Insights into N-Glycan Recognition and Hydrolysis

(2011) Benjamin Pluvinage et al.   STRUCTURE

The Conformation and Function of a Multimodular Glycogen-Degrading Pneumococcal Virulence Factor

(2011) Alicia Lammerts van Bueren et al.   STRUCTURE

Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database

(2011) George A. Khoury et al.   Scientific Reports

The N-glycan Glycoprotein Deglycosylation Complex (Gpd) from Capnocytophaga canimorsus Deglycosylates Human IgG

(2011) Francesco Renzi et al.   PLoS Pathogens

Activation of brain endothelium by pneumococcal neuraminidase NanA promotes bacterial internalization

(2010) Anirban Banerjee et al.   CELLULAR MICROBIOLOGY

Proteoglycans in host–pathogen interactions: molecular mechanisms and therapeutic implications

(2010) Allison H. Bartlett et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Three Surface Exoglycosidases from Streptococcus pneumoniae, NanA, BgaA, and StrH, Promote Resistance to Opsonophagocytic Killing by Human Neutrophils

(2010) A. B. Dalia et al.   INFECTION AND IMMUNITY

Sialic Acid Transport Contributes to Pneumococcal Colonization

(2010) Carolyn Marion et al.   INFECTION AND IMMUNITY

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

The molecular basis of glycogen breakdown and transport in Streptococcus pneumoniae

(2010) D. Wade Abbott et al.   MOLECULAR MICROBIOLOGY

Pneumococcal modification of host sugars: a major contributor to colonization of the human airway?

(2010) S.J. King   Molecular Oral Microbiology

Structure and Kinetic Investigation of Streptococcus pyogenes Family GH38 α-Mannosidase

(2010) Michael D. L. Suits et al.   PLoS One

Crystal structures of respiratory pathogen neuraminidases

(2009) Yu-Shan Hsiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanistic Investigation of the Endo-α-N-acetylgalactosaminidase fromStreptococcus pneumoniaeR6

(2009) Lisa M. Willis et al.   BIOCHEMISTRY

Characterization of Novel  -Galactosidase Activity That Contributes to Glycoprotein Degradation and Virulence in Streptococcus pneumoniae

(2009) V. S. Terra et al.   INFECTION AND IMMUNITY

Identification of a Pneumococcal Glycosidase That Modifies O-Linked Glycans

(2009) C. Marion et al.   INFECTION AND IMMUNITY

The NanA Neuraminidase of Streptococcus pneumoniae Is Involved in Biofilm Formation

(2009) D. Parker et al.   INFECTION AND IMMUNITY

Characterization of the Streptococcus pneumoniae BgaC Protein as a Novel Surface  -Galactosidase with Specific Hydrolysis Activity for the Gal 1-3GlcNAc Moiety of Oligosaccharides

(2009) J. K. Jeong et al.   JOURNAL OF BACTERIOLOGY

Substrate Specificity of Streptococcal Unsaturated Glucuronyl Hydrolases for Sulfated Glycosaminoglycan

(2009) Yukie Maruyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Streptococcus pneumoniaeEndohexosaminidase D, Structural and Mechanistic Insight into Substrate-assisted Catalysis in Family 85 Glycoside Hydrolases

(2009) D. Wade Abbott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Recognition and Hydrolysis of Host Carbohydrate Antigens byStreptococcus pneumoniaeFamily 98 Glycoside Hydrolases

(2009) Melanie A. Higgins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion

(2009) Satoshi Uchiyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pattern of Accessory Regions and Invasive Disease Potential inStreptococcus pneumoniae

(2009) C. Blomberg et al.   JOURNAL OF INFECTIOUS DISEASES

Sialic Acid: A Preventable Signal for Pneumococcal Biofilm Formation, Colonization, and Invasion of the Host

(2009) Claudia Trappetti et al.   JOURNAL OF INFECTIOUS DISEASES

Blood Group Antigen Recognition by a Solute-Binding Protein from a Serotype 3 Strain of Streptococcus pneumoniae

(2009) Melanie A. Higgins et al.   JOURNAL OF MOLECULAR BIOLOGY

EstA protein, a novel virulence factor of Streptococcus pneumoniae, induces nitric oxide and pro-inflammatory cytokine production in RAW 264.7 macrophages through NF-κB/MAPK

(2009) Eun Hee Kang et al.   MICROBIAL PATHOGENESIS

Streptococcus Adherence and Colonization

(2009) A. H. Nobbs et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Structure of the catalytic domain ofStreptococcus pneumoniaesialidase NanA

(2008) Guogang Xu et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Molecular cloning, expression, and characterization of a novel endo-α-N-acetylgalactosaminidase from Enterococcus faecalis

(2008) Hatsumi M. Goda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Structure of Glycosaminoglycans and their Interactions with Proteins

(2008) Neha S. Gandhi et al.   Chemical Biology & Drug Design

Structural and functional studies ofStreptococcus pneumoniaeneuraminidase B: An intramoleculartrans-sialidase

(2008) Heinz Gut et al.   FEBS LETTERS

The ability to utilize mucin affects the regulation of virulence gene expression inStreptococcus pneumoniae

(2008) Hasan Yesilkaya et al.   FEMS MICROBIOLOGY LETTERS

The Structural Basis for T-antigen Hydrolysis byStreptococcus pneumoniae

(2008) Matthew E. C. Caines et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the NanB Sialidase from Streptococcus pneumoniae

(2008) Guogang Xu et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems

(2008) A. L. Davidson et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Molecular characterization of group AStreptococcusmaltodextrin catabolism and its role in pharyngitis

(2008) Samuel A. Shelburne et al.   MOLECULAR MICROBIOLOGY

Genetic Requirement for Pneumococcal Ear Infection

(2008) Huaiqing Chen et al.   PLoS One

Domain motions of hyaluronan lyase underlying processive hyaluronan translocation

(2008) Harshad V. Joshi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS