Visualization of early events in mRNA vaccine delivery in non-human primates via PET–CT and near-infrared imaging

Unifying in vitro and in vivo IVT mRNA expression discrepancies in skeletal muscle via mechanotransduction

(2018) Sushma M. Bhosle et al.   BIOMATERIALS

Routing dependent immune responses after experimental R848-adjuvated vaccination

(2018) Susan van Aalst et al.   VACCINE

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

(2017) Matthias Pauthner et al.   IMMUNITY

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: Restoring the immunogenicity of immunosilent mRNA

(2017) Rein Verbeke et al.   JOURNAL OF CONTROLLED RELEASE

Self-assembling complexes between binary mixtures of lipids with different linkers and nucleic acids promote universal mRNA, DNA and siRNA delivery

(2017) Thibault Colombani et al.   JOURNAL OF CONTROLLED RELEASE

Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques

(2017) Frank Liang et al.   MOLECULAR THERAPY

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

(2017) Norbert Pardi et al.   NATURE

The 'anti-hype' vaccine

(2017) Laura DeFrancesco   NATURE BIOTECHNOLOGY

Characterizing exogenous mRNA delivery, trafficking, cytoplasmic release and RNA–protein correlations at the level of single cells

(2017) Jonathan L. Kirschman et al.   NUCLEIC ACIDS RESEARCH

Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake

(2017) Frank Liang et al.   Science Translational Medicine

Implications of Lymphatic Transport to Lymph Nodes in Immunity and Immunotherapy

(2016) Susan N. Thomas et al.   Annual Review of Biomedical Engineering

Design of Ionizable Lipids To Overcome the Limiting Step of Endosomal Escape: Application in the Intracellular Delivery of mRNA, DNA, and siRNA

(2016) Damien Habrant et al.   JOURNAL OF MEDICINAL CHEMISTRY

Imaging viral RNA using multiply labeled tetravalent RNA imaging probes in live cells

(2016) Eric Alonas et al.   METHODS

Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon

(2016) Katrijn Broos et al.   Molecular Therapy-Nucleic Acids

Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naïve subjects

(2015) Sharon E. Frey et al.   VACCINE

Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines

(2014) Raquel P Deering et al.   Expert Opinion on Drug Delivery

mRNA-based dendritic cell vaccines

(2014) Daphné Benteyn et al.   Expert Review of Vaccines

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Targeting co-stimulatory pathways: transplantation and autoimmunity

(2013) Mandy L. Ford et al.   Nature Reviews Nephrology

Kinetics of the inflammatory response following intramuscular injection of aluminum adjuvant

(2013) Fangjia Lu et al.   VACCINE

Cationic lipids activate intracellular signaling pathways

(2012) Caroline Lonez et al.   ADVANCED DRUG DELIVERY REVIEWS

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

(2012) Charlotte Pollard et al.   MOLECULAR THERAPY

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

(2012) Benjamin Petsch et al.   NATURE BIOTECHNOLOGY

Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

(2011) M Diken et al.   GENE THERAPY

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes

(2011) Samuele Calabro et al.   VACCINE

Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity

(2010) Mariola Fotin-Mleczek et al.   JOURNAL OF IMMUNOTHERAPY

Fundamental limits of spatial resolution in PET

(2010) William W. Moses   NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Evaluating a surrogate endpoint at three levels, with application to vaccine development

(2007) Peter B. Gilbert et al.   STATISTICS IN MEDICINE