Itaconate is a lysosomal inducer that promotes antibacterial innate immunity

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

(2022) Marah C. Runtsch et al.   Cell Metabolism

Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

(2022) Lei-Lei Chen et al.   NATURE CELL BIOLOGY

A NOVEL NOX/PHOX-CD38-NAADP-TFEB AXIS IMPORTANT FOR MACROPHAGE ACTIVATION DURING BACTERIAL PHAGOCYTOSIS

(2021) Mehran Najibi et al.   Autophagy

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

(2020) Alexander Hooftman et al.   Cell Metabolism

Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids

(2020) Eva Bartok et al.   IMMUNITY

Chemoproteomic Profiling of Itaconation by Bioorthogonal Probes in Inflammatory Macrophages

(2020) Wei Qin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology

(2020) Jade D. Bailey et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Macrophages and the maintenance of homeostasis

(2020) David M. Mosser et al.   Cellular & Molecular Immunology

A conserved cysteine‐based redox mechanism sustains TFEB/HLH‐30 activity under persistent stress

(2020) José A Martina et al.   EMBO JOURNAL

The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen Resistance

(2019) Leeanna El-Houjeiri et al.   Cell Reports

S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate

(2019) Wei Qin et al.   Nature Chemical Biology

Lysosomes as a therapeutic target

(2019) Srinivasa Reddy Bonam et al.   NATURE REVIEWS DRUG DISCOVERY

Restriction of intracellular Salmonella replication by restoring TFEB-mediated xenophagy

(2019) Veena Ammanathan et al.   Autophagy

Palmitoylation of NOD1 and NOD2 is required for bacterial sensing

(2019) Yan Lu et al.   SCIENCE

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

(2019) Shan-Ting Liao et al.   Nature Communications

Quantitative 1H NMR Metabolomics Reveal Distinct Metabolic Adaptations in Human Macrophages Following Differential Activation

(2019) Amanda L. Fuchs et al.   Metabolites

Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis

(2019) Hongfeng Wang et al.   Autophagy

Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation

(2019) Victoria E. B. Hipolito et al.   PLOS BIOLOGY

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

(2018) Rosa Puertollano et al.   EMBO JOURNAL

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

(2017) Xinjian Li et al.   MOLECULAR CELL

From bacterial killing to immune modulation: Recent insights into the functions of lysozyme

(2017) Stephanie A. Ragland et al.   PLoS Pathogens

TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages

(2016) Nunzia Pastore et al.   Autophagy

Phagocytosis Enhances Lysosomal and Bactericidal Properties by Activating the Transcription Factor TFEB

(2016) Matthew A. Gray et al.   CURRENT BIOLOGY

An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense

(2016) Mehran Najibi et al.   Cell Reports

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Innate Host Defense Requires TFEB-Mediated Transcription of Cytoprotective and Antimicrobial Genes

(2014) Orane Visvikis et al.   IMMUNITY

The Roles of Lysosomes in Inflammation and Autoimmune Diseases

(2014) Wei Ge et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation

(2011) Cheryl L. Strelko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Distinct Roles for the NF- B RelA Subunit during Antiviral Innate Immune Responses

(2011) S. H. Basagoudanavar et al.   JOURNAL OF VIROLOGY

Non-targeted metabolite profiling in activated macrophage secretion

(2011) Masahiro Sugimoto et al.   Metabolomics

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE