A NOVEL NOX/PHOX-CD38-NAADP-TFEB AXIS IMPORTANT FOR MACROPHAGE ACTIVATION DURING BACTERIAL PHAGOCYTOSIS

NAADP ‐regulated two‐pore channels drive phagocytosis through endo‐lysosomal Ca 2+ nanodomains, calcineurin and dynamin

(2020) Lianne C Davis et al.   EMBO JOURNAL

DEBrowser: interactive differential expression analysis and visualization tool for count data

(2019) Alper Kucukural et al.   BMC GENOMICS

The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen Resistance

(2019) Leeanna El-Houjeiri et al.   Cell Reports

Purine Release, Metabolism, and Signaling in the Inflammatory Response

(2019) Joel Linden et al.   Annual Review of Immunology

Nutrient‐sensitive transcription factors TFEB and TFE3 couple autophagy and metabolism to the peripheral clock

(2019) Nunzia Pastore et al.   EMBO JOURNAL

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

(2019) Uku Raudvere et al.   NUCLEIC ACIDS RESEARCH

Pharmacological characterization of the seven human NOX isoforms and their inhibitors

(2019) Fiona Augsburger et al.   Redox Biology

Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis

(2019) Hongfeng Wang et al.   Autophagy

Antimycobacterial effect of IFNG (interferon gamma)-induced autophagy depends on HMOX1 (heme oxygenase 1)-mediated increase in intracellular calcium levels and modulation of PPP3/calcineurin-TFEB (transcription factor EB) axis

(2018) Nisha Singh et al.   Autophagy

TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis

(2018) Trent D. Evans et al.   Autophagy

TRPML1: The Ca (2+) retaker of the lysosome

(2018) Simone Di Paola et al.   CELL CALCIUM

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

(2018) Rosa Puertollano et al.   EMBO JOURNAL

CD38 produces nicotinic acid adenosine dinucleotide phosphate in the lysosome

(2018) Cheng Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress

(2018) José A. Martina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging

(2018) Eduardo N. Chini et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions

(2018) Stephanie A. Amici et al.   Frontiers in Immunology

Oxidative activation of type III CD38 by NADPH oxidase–derived hydrogen peroxide in Ca2+ signaling

(2018) Dae-Ryoung Park et al.   FASEB JOURNAL

Lysosomal Ion Channels as Decoders of Cellular Signals

(2018) Ping Li et al.   TRENDS IN BIOCHEMICAL SCIENCES

NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury

(2017) So-Young Rah et al.   FASEB JOURNAL

Chemical basis for the disparate neuroprotective effects of the anthocyanins, callistephin and kuromanin, against nitrosative stress

(2017) Aimee N. Winter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor γ2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice

(2017) Nunciada Salma et al.   MOLECULAR AND CELLULAR BIOLOGY

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

The Reactome Pathway Knowledgebase

(2017) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

(2017) Ismail Sergin et al.   Nature Communications

The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism

(2017) Jonathan Matalonga et al.   Cell Reports

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

(2016) Nina Raben et al.   Annual Review of Cell and Developmental Biology

TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages

(2016) Nunzia Pastore et al.   Autophagy

Intracellular CD38 Mediates Cardiac Synthesis of NAADP and CADPR

(2016) Wee Khang Lin et al.   BIOPHYSICAL JOURNAL

Phagocytosis Enhances Lysosomal and Bactericidal Properties by Activating the Transcription Factor TFEB

(2016) Matthew A. Gray et al.   CURRENT BIOLOGY

Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism

(2016) Mireille Ouimet et al.   NATURE IMMUNOLOGY

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

(2016) Xiaoli Zhang et al.   Nature Communications

An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense

(2016) Mehran Najibi et al.   Cell Reports

Determinants of the membrane orientation of a calcium signaling enzyme CD38

(2015) Yong Juan Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Activator of G-Protein Signaling 3–Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection

(2015) Ali Vural et al.   JOURNAL OF IMMUNOLOGY

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

CD38 Is Expressed on Inflammatory Cells of the Intestine and Promotes Intestinal Inflammation

(2015) Michael Schneider et al.   PLoS One

Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae

(2014) Roy Emanuel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Innate Host Defense Requires TFEB-Mediated Transcription of Cytoprotective and Antimicrobial Genes

(2014) Orane Visvikis et al.   IMMUNITY

A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis

(2013) Mohammad Samie et al.   DEVELOPMENTAL CELL

CD38 Controls the Innate Immune Response against Listeria monocytogenes

(2013) Timo Lischke et al.   INFECTION AND IMMUNITY

Apocynin: Chemical and Biophysical Properties of a NADPH Oxidase Inhibitor

(2013) Maicon Petrônio et al.   MOLECULES

Contribution of NADPH Oxidase to Membrane CD38 Internalization and Activation in Coronary Arterial Myocytes

(2013) Ming Xu et al.   PLoS One

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

(2012) C. Escande et al.   DIABETES

The Role of CD38 in Fcγ Receptor (FcγR)-mediated Phagocytosis in Murine Macrophages

(2012) John Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Salmonella Inhibits Retrograde Trafficking of Mannose-6-Phosphate Receptors and Lysosome Function

(2012) K. McGourty et al.   SCIENCE

Role of Protein Kinase D in Golgi Exit and Lysosomal Targeting of the Transmembrane Protein, Mcoln1

(2012) David L. Marks et al.   TRAFFIC

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

(2012) Dongbiao Shen et al.   Nature Communications

Flavonoids as inhibitors of human CD38

(2011) Esther Kellenberger et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

How does the oxidative burst of macrophages kill bacteria? Still an open question

(2011) James M. Slauch   MOLECULAR MICROBIOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Apigenin: A Promising Molecule for Cancer Prevention

(2010) Sanjeev Shukla et al.   PHARMACEUTICAL RESEARCH

Division of the Salmonella-Containing Vacuole and Depletion of Acidic Lysosomes in Salmonella-Infected Host Cells Are Novel Strategies of Salmonella enterica To Avoid Lysosomes

(2009) S. M. Eswarappa et al.   INFECTION AND IMMUNITY

Identification of a chemical probe for NAADP by virtual screening

(2009) Edmund Naylor et al.   Nature Chemical Biology

Inhibition of proteasome activity by anthocyanins and anthocyanidins

(2008) Andrea Dreiseitel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NAADP: A Universal Ca2+ Trigger

(2008) A. H. Guse et al.   Science Signaling

Cell-permeant NAADP: A novel chemical tool enabling the study of Ca2+ signalling in intact cells

(2007) Raman Parkesh et al.   CELL CALCIUM

Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant

(2007) Sabine Heumüller et al.   HYPERTENSION