Treatment with spexin mitigates diet-induced hepatic steatosis in vivo and in vitro through activation of galanin receptor 2

Effect of spexin on renal dysfunction in experimentally obese rats: potential mitigating mechanisms via galanin receptor-2

(2021) Mervat H. El-Saka et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Spexin alleviates hypertension, hyperuricaemia, dyslipidemia and insulin resistance in high fructose diet induced metabolic syndrome in rats via enhancing PPAR-ɣ and AMPK and inhibiting IL-6 and TNF-α

(2021) Mona A. Said et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Metabolic-associated fatty liver disease and lipoprotein metabolism

(2021) Joerg Heeren et al.   Molecular Metabolism

Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus

(2021) Matthew K. H. Wong et al.   Frontiers in Endocrinology

Adipose tissue spexin in physical exercise and age-associated diseases

(2021) Penghua Fang et al.   AGEING RESEARCH REVIEWS

Spexin ameliorates skeletal muscle insulin resistance through activation of GAL2 receptor

(2021) Mei Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

30-Day spexin treatment of mice with diet-induced obesity (DIO) and type 2 diabetes (T2DM) increases insulin sensitivity, improves liver functions and metabolic status

(2021) Pawel A. Kolodziejski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Spexin Promotes the Proliferation and Differentiation of C2C12 Cells In Vitro—The Effect of Exercise on SPX and SPX Receptor Expression in Skeletal Muscle In Vivo

(2021) Natalia Leciejewska et al.   Genes

Non-alcoholic fatty liver disease and steatohepatitis: State of the art on effective therapeutics based on the gold standard method for diagnosis

(2020) Maryam Mahjoubin-Tehran et al.   Molecular Metabolism

Short-term administration of spexin in rats reduces obesity by affecting lipolysis and lipogenesis: An in vivo and in vitro study

(2020) Ewa Pruszynska-Oszmalek et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Palmitate differentially regulates Spexin, and its receptors Galr2 and Galr3, in GnRH neurons through mechanisms involving PKC, MAPKs, and TLR4

(2020) Lu Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight

(2019) Seongsik Yun et al.   Frontiers in Neuroscience

Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction

(2019) Yang Liu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Galanin peptide family regulation of glucose metabolism

(2019) Penghua Fang et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence?

(2018) Amedeo Lonardo et al.   JOURNAL OF HEPATOLOGY

Roux en-Y gastric bypass surgery in youth with severe obesity: 1-year longitudinal changes in spexin

(2018) Seema Kumar et al.   Surgery for Obesity and Related Diseases

Spexin: A novel regulator of adipogenesis and fat tissue metabolism

(2018) Pawel A. Kolodziejski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Spexin Levels Are Associated with Metabolic Syndrome Components

(2018) Nasser M. Al-Daghri et al.   DISEASE MARKERS

Decreased Spexin Levels in Patients with Type 1 and Type 2 Diabetes

(2018) Anara Karaca et al.   MEDICAL PRINCIPLES AND PRACTICE

Estrogen Signals Through Peroxisome Proliferator-Activated Receptor−γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease

(2017) Aurèle Besse-Patin et al.   GASTROENTEROLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Decreased Circulating Levels of Spexin in Obese Children

(2016) Seema Kumar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Gestational exercise protects adult male offspring from high-fat diet-induced hepatic steatosis

(2016) Ryan D. Sheldon et al.   JOURNAL OF HEPATOLOGY

Epidemiology and natural history of non-alcoholic fatty liver disease

(2016) Yousef Fazel et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Non-alcoholic fatty liver disease and diabetes

(2016) Jonathan M. Hazlehurst et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Regulation of Hepatocellular Fatty Acid Uptake in Mouse Models of Fatty Liver Disease with and without Functional Leptin Signaling: Roles of NfKB and SREBP-1C and the Effects of Spexin

(2016) Jasmine Ge et al.   SEMINARS IN LIVER DISEASE

Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes

(2015) Liping Gu et al.   PEPTIDES

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity

(2014) José L. Walewski et al.   Obesity

Reduced hepatic mitochondrial respiration following acute high-fat diet is prevented by PGC-1α overexpression

(2013) E. Matthew Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery

(2013) Markus Ahrens et al.   Cell Metabolism

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

PGC-1α overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion

(2012) E. Matthew Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice

(2011) Michal Aharoni-Simon et al.   LABORATORY INVESTIGATION

The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+

(2011) Zachary Gerhart-Hines et al.   MOLECULAR CELL

Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator-Activated Receptor-  Coactivator-1  Expression

(2009) J. L. Estall et al.   DIABETES

Adipocyte Accumulation of Long-Chain Fatty Acids in Obesity is Multifactorial, Resulting from Increased Fatty Acid Uptake and Decreased Activity of Genes Involved in Fat Utilization

(2009) José L. Walewski et al.   OBESITY SURGERY