Spexin alleviates hypertension, hyperuricaemia, dyslipidemia and insulin resistance in high fructose diet induced metabolic syndrome in rats via enhancing PPAR-ɣ and AMPK and inhibiting IL-6 and TNF-α

Linking cellular energy state to atrial fibrillation pathogenesis: Potential role of adenosine monophosphate–activated protein kinase

(2020) Praloy Chakraborty et al.   HEART RHYTHM

“Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice”

(2020) Sabrina Eliana Gambaro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Short-term administration of spexin in rats reduces obesity by affecting lipolysis and lipogenesis: An in vivo and in vitro study

(2020) Ewa Pruszynska-Oszmalek et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction

(2019) Yang Liu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Elevated Triglycerides (≥150 mg/dL) and High Triglycerides (200–499 mg/dL) Are Significant Predictors of Hospitalization for New-Onset Kidney Disease: A Real-World Analysis of High-Risk Statin-Treated Patients

(2019) Peter P. Toth et al.   CardioRenal Medicine

The effects of l-Carnosine on development of metabolic syndrome in rats

(2019) Nour A. Al-Sawalha et al.   LIFE SCIENCES

Dietary Fructose and the Metabolic Syndrome

(2019) Taskinen et al.   Nutrients

Oxidative Stress-Related Endothelial Damage in Vascular Depression and Vascular Cognitive Impairment: Beneficial Effects of Aerobic Physical Exercise

(2019) Maria Luca et al.   Oxidative Medicine and Cellular Longevity

PPAR Agonists and Metabolic Syndrome: An Established Role?

(2018) Margherita Botta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Spexin Modulates Functions of Rat Endocrine Pancreatic Cells

(2018) Maciej Sassek et al.   PANCREAS

Spexin Acts as Novel Regulator for Bile Acid Synthesis

(2018) Cheng-yuan Lin et al.   Frontiers in Physiology

Spexin Levels Are Associated with Metabolic Syndrome Components

(2018) Nasser M. Al-Daghri et al.   DISEASE MARKERS

High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model

(2018) Silvia Moreno-Fernández et al.   Nutrients

Regulation of Hepatocellular Fatty Acid Uptake in Mouse Models of Fatty Liver Disease with and without Functional Leptin Signaling: Roles of NfKB and SREBP-1C and the Effects of Spexin

(2016) Jasmine Ge et al.   SEMINARS IN LIVER DISEASE

Targeting inflammation in metabolic syndrome

(2016) Francine K. Welty et al.   Translational Research

PPARγ Regulation in Hypertension and Metabolic Syndrome

(2015) Madeliene Stump et al.   CURRENT HYPERTENSION REPORTS

Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes

(2015) Liping Gu et al.   PEPTIDES

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

(2014) Nathalie Esser et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity

(2014) José L. Walewski et al.   Obesity

A Comprehensive Review on Metabolic Syndrome

(2014) Jaspinder Kaur   Cardiology Research and Practice

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Fructose-Fed Rhesus Monkeys: A Nonhuman Primate Model of Insulin Resistance, Metabolic Syndrome, and Type 2 Diabetes

(2011) Andrew A. Bremer et al.   CTS-Clinical and Translational Science

Spexin Expression in Normal Rat Tissues

(2010) Andrea Porzionato et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Fructose and metabolic diseases: New findings, new questions

(2010) Luc Tappy et al.   NUTRITION

AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

(2009) Bei B. Zhang et al.   Cell Metabolism

The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension

(2009) Linda T. Tran et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY