30-Day spexin treatment of mice with diet-induced obesity (DIO) and type 2 diabetes (T2DM) increases insulin sensitivity, improves liver functions and metabolic status

Short-term administration of spexin in rats reduces obesity by affecting lipolysis and lipogenesis: An in vivo and in vitro study

(2020) Ewa Pruszynska-Oszmalek et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Favorable Changes in Fasting Glucose in a 6-month Self-Monitored Lifestyle Modification Programme Inversely Affects Spexin Levels in Females with Prediabetes

(2019) Nasser M. Al-Daghri et al.   Scientific Reports

Different Spexin level in Obese vs Normal Weight Children and Its Relationship with Obesity Related Risk Factors

(2019) Maryam Behrooz et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Circulating spexin levels are influenced by the presence or absence of gestational diabetes

(2018) Nasser M. Al-Daghri et al.   CYTOKINE

The Role of Glucagon in the Pathophysiology and Treatment of Type 2 Diabetes

(2018) Sofie Hædersdal et al.   MAYO CLINIC PROCEEDINGS

Spexin Modulates Functions of Rat Endocrine Pancreatic Cells

(2018) Maciej Sassek et al.   PANCREAS

Associations of Spexin and cardiometabolic parameters among women with and without gestational diabetes mellitus

(2018) Nasser M. Al-Daghri et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Astragaloside IV Inhibits Adipose Lipolysis and Reduces Hepatic Glucose Production via Akt Dependent PDE3B Expression in HFD-Fed Mice

(2018) Qun Du et al.   Frontiers in Physiology

Spexin: A novel regulator of adipogenesis and fat tissue metabolism

(2018) Pawel A. Kolodziejski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Decreased Spexin Levels in Patients with Type 1 and Type 2 Diabetes

(2018) Anara Karaca et al.   MEDICAL PRINCIPLES AND PRACTICE

Nonalcoholic fatty liver disease promotes hepatocellular carcinoma through direct and indirect effects on hepatocytes

(2017) Chi Ma et al.   FEBS Journal

Targeting hepatic glucose metabolism in the treatment of type 2 diabetes

(2016) Amy K. Rines et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of Hepatocellular Fatty Acid Uptake in Mouse Models of Fatty Liver Disease with and without Functional Leptin Signaling: Roles of NfKB and SREBP-1C and the Effects of Spexin

(2016) Jasmine Ge et al.   SEMINARS IN LIVER DISEASE

RELATIONSHIP OF ADIPOKINES AND PROINFLAMMATORY CYTOKINES AMONG ASIAN INDIANS WITH OBESITY AND YOUTH ONSET TYPE 2 DIABETES

(2015) Kuppan Gokulakrishnan et al.   Endocrine Practice

Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes

(2015) Liping Gu et al.   PEPTIDES

Coevolution of the Spexin/Galanin/Kisspeptin Family: Spexin Activates Galanin Receptor Type II and III

(2014) Dong-Kyu Kim et al.   ENDOCRINOLOGY

Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity

(2014) José L. Walewski et al.   Obesity

Goldfish spexin: solution structure and novel function as a satiety factor in feeding control

(2013) Matthew K. H. Wong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Mixed Mirror-image DNA/RNA Aptamer Inhibits Glucagon and Acutely Improves Glucose Tolerance in Models of Type 1 and Type 2 Diabetes

(2013) Axel Vater et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel neuropeptide in suppressing luteinizing hormone release in goldfish, Carassius auratus

(2013) Yun Liu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

Role of cytokines and chemokines in non-alcoholic fatty liver disease

(2012) Vincent Braunersreuther   WORLD JOURNAL OF GASTROENTEROLOGY

Secondary causes of nonalcoholic fatty liver disease

(2011) Jacob M. Kneeman et al.   Therapeutic Advances in Gastroenterology

Spexin Expression in Normal Rat Tissues

(2010) Andrea Porzionato et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice

(2010) Kanji Yamaguchi et al.   LABORATORY INVESTIGATION

The Characterization of High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat Model

(2009) Ming Zhang et al.   Experimental Diabetes Research

Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses

(2009) M. Judith Radin et al.   VETERINARY CLINICAL PATHOLOGY

Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis

(2008) Anna Wieckowska et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats

(2008) J. Cacho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM