Enterohepatic and non-canonical roles of farnesoid X receptor in controlling lipid and glucose metabolism

Farnesoid X receptor (FXR) agonist ameliorates systemic insulin resistance, dysregulation of lipid metabolism, and alterations of various organs in a type 2 diabetic kidney animal model

(2021) Sang Youb Han et al.   ACTA DIABETOLOGICA

Transcriptional Regulation of Metabolic Pathways via Lipid-Sensing Nuclear Receptors

(2021) Marica Cariello et al.   Cellular and Molecular Gastroenterology and Hepatology

Bile acids and their receptors in metabolic disorders

(2021) Stefano Fiorucci et al.   PROGRESS IN LIPID RESEARCH

FXR in liver physiology: Multiple faces to regulate liver metabolism

(2021) Katrin Panzitt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Knockout of farnesoid X receptor aggravates process of diabetic cardiomyopathy

(2020) Sujing Qiang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Farnesoid X receptor-mediated cytoplasmic translocation of CRTC2 disrupts CREB-BDNF signaling in hippocampal CA1 and leads to the development of depression-like behaviors in mice

(2020) Wenfeng Hu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle

(2020) Ai Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Promotion of lipogenesis by PPARγ-activated FXR expression in adipocytes

(2020) Saki Shinohara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs

(2020) Jose Miguel Ramos Pittol et al.   GASTROENTEROLOGY

Bile Acid Supplementation Improves Murine Pancreatitis in Association With the Gut Microbiota

(2020) You-Dong Wan et al.   Frontiers in Physiology

Fxr-alpha Skips Alternatively in Liver Metabolism

(2020) Sayeepriyadarshini Anakk et al.   GASTROENTEROLOGY

FXR in the dorsal vagal complex is sufficient and necessary for upper small intestinal microbiome-mediated changes of TCDCA to alter insulin action in rats

(2020) Song-Yang Zhang et al.   GUT

Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1

(2019) Lei Liu et al.   LIVER INTERNATIONAL

Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis

(2019) Sangwon Byun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chenodeoxycholic Acid Ameliorates AlCl3-Induced Alzheimer’s Disease Neurotoxicity and Cognitive Deterioration via Enhanced Insulin Signaling in Rats

(2019) Firas H. Bazzari et al.   MOLECULES

Farnesoid X Receptor alters adipose tissue architecture in mice and limits storage capacity leading to metabolic derangements

(2019) Tim van Zutphen et al.   JOURNAL OF LIPID RESEARCH

FXR Mediates Adenylyl Cyclase 8 Expression in Pancreatic β-Cells

(2019) Xiangchen Kong et al.   Journal of Diabetes Research

Roux-en-Y gastric bypass enhances insulin secretion in type 2 diabetes via FXR-mediated TRPA1 expression

(2019) Xiangchen Kong et al.   Molecular Metabolism

Farnesoid X receptor: A “homeostat” for hepatic nutrient metabolism

(2018) Vittoria Massafra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Adiponectin determines farnesoid X receptor agonism-mediated cardioprotection against post-infarction remodelling and dysfunction

(2018) Yunlong Xia et al.   CARDIOVASCULAR RESEARCH

Cholestasis-induced bile acid elevates estrogen level via farnesoid X receptor–mediated suppression of the estrogen sulfotransferase SULT1E1

(2018) Xijun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hippocampal FXR plays a role in the pathogenesis of depression: A preliminary study based on lentiviral gene modulation

(2018) Wei-Guan Chen et al.   PSYCHIATRY RESEARCH

Effects of farnesoid-X-receptor SUMOylation mutation on myocardial ischemia/reperfusion injury in mice

(2018) Yi Gao et al.   EXPERIMENTAL CELL RESEARCH

Farnesoid X receptor interacts with cAMP response element binding protein to modulate glucagon‐like peptide‐1 (7–36) amide secretion by intestinal L cell

(2018) Pengzhou Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice

(2017) Oludemilade Akinrotimi et al.   HEPATOLOGY

RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism

(2017) Elizabeth J. Tarling et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of FXR pathway does not alter glial cell function

(2017) Stefanie Albrecht et al.   Journal of Neuroinflammation

FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity

(2017) Xiaoxin X. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

(2017) Bérengère Benoit et al.   NATURE MEDICINE

Farnesoid X Receptor and Its Ligands Inhibit the Function of PlateletsHighlights

(2016) Leonardo A. Moraes et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bile acid receptor agonists INT747 and INT777 decrease oestrogen deficiency-related postmenopausal obesity and hepatic steatosis in mice

(2016) Monique C. de Oliveira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice

(2016) Cen Xie et al.   DIABETES

Identification of functional farnesoid X receptors in brain neurons

(2016) Chao Huang et al.   FEBS LETTERS

Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice

(2016) Yang Xu et al.   HEPATOLOGY

Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression

(2016) Qingli Liu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism

(2015) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance

(2015) Mohamed Sham Shihabudeen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

(2015) Mohamed-Sami Trabelsi et al.   Nature Communications

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

(2015) Jorge C. Correia et al.   Molecular Metabolism

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Farnesoid X receptor (FXR) gene deficiency impairs urine concentration in mice

(2014) Xiaoyan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells

(2014) Xiao-Min Xin   WORLD JOURNAL OF GASTROENTEROLOGY

Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition

(2013) Javier Vaquero et al.   BIOCHEMICAL PHARMACOLOGY

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis

(2013) Jiesi Xu et al.   HEPATOLOGY

FXR activation normalizes insulin sensitivity in visceral preadipocytes of a rabbit model of MetS

(2013) Elena Maneschi et al.   JOURNAL OF ENDOCRINOLOGY

Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor

(2013) Xiulong Song et al.   JOURNAL OF LIPID RESEARCH

Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice

(2013) Yanjun Jiang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Farnesoid X Receptor Inhibits the Transcriptional Activity of Carbohydrate Response Element Binding Protein in Human Hepatocytes

(2013) S. Caron et al.   MOLECULAR AND CELLULAR BIOLOGY

FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway

(2013) Dongju Jung et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Synthetic FXR Agonist GW4064 Prevents Diet-Induced Hepatic Steatosis and Insulin Resistance

(2013) Yongjie Ma et al.   PHARMACEUTICAL RESEARCH

Nuclear receptor atlas of female mouse liver parenchymal, endothelial, and Kupffer cells

(2013) Zhaosha Li et al.   PHYSIOLOGICAL GENOMICS

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

(2013) Fei Li et al.   Nature Communications

Bile Acids Acutely Stimulate Insulin Secretion of Mouse  -Cells via Farnesoid X Receptor Activation and KATP Channel Inhibition

(2012) M. Dufer et al.   DIABETES

Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury

(2012) Jun Pu et al.   EUROPEAN HEART JOURNAL

Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice

(2012) Bo Kong et al.   HEPATOLOGY

Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma

(2012) Yuan Chen et al.   HEPATOLOGY

Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause?

(2012) David van der Poorten et al.   HEPATOLOGY

FXR agonist GW4064 increases plasma glucocorticoid levels in C57BL/6 mice

(2012) Menno Hoekstra et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Fibroblast Growth Factor 19 Treatment Ameliorates Disruption of Hepatic Lipid Metabolism in Farnesoid X Receptor (Fxr)-Null Mice

(2011) Masaaki Miyata et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

(2011) Matthew J. Potthoff et al.   Cell Metabolism

Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

(2011) J. Prawitt et al.   DIABETES

Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure

(2011) Mitsuhiro Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FXR activation improves myocardial fatty acid metabolism in a rodent model of obesity-driven cardiotoxicity

(2011) A. Mencarelli et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

(2011) S. Kir et al.   SCIENCE

Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro☆

(2010) Deanna L. Howarth et al.   AQUATIC TOXICOLOGY

The bile acid sensor FXR regulates insulin transcription and secretion

(2010) Barbara Renga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The nuclear receptor FXR is expressed in pancreatic β-cells and protects human islets from lipotoxicity

(2010) Iuliana Ristea Popescu et al.   FEBS LETTERS

The Farnesoid X Receptor Regulates Adipocyte Differentiation and Function by Promoting Peroxisome Proliferator-activated Receptor-γ and Interfering with the Wnt/β-Catenin Pathways

(2010) Mouaadh Abdelkarim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR

(2010) Matthew D. Krasowski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Diversity of Bile Salts in Fish and Amphibians: Evolution of a Complex Biochemical Pathway

(2010) Lee R. Hagey et al.   PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY

Fibroblast Growth Factor-19, a Novel Factor That Inhibits Hepatic Fatty Acid Synthesis

(2009) Sushant Bhatnagar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bile salts of vertebrates: structural variation and possible evolutionary significance

(2009) Alan F. Hofmann et al.   JOURNAL OF LIPID RESEARCH

Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR−/−and apoE−/−mice

(2009) Helen B. Hartman et al.   JOURNAL OF LIPID RESEARCH

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

(2008) A. F. Hofmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Coordinated Nuclear Receptor Regulation of the Efflux Transporter, Mrp2, and the Phase-Ii Metabolizing Enzyme, GSTπ, at the Blood—Brain Barrier

(2008) Björn Bauer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Evolution of the bile salt nuclear receptor FXR in vertebrates

(2008) Erica J. Reschly et al.   JOURNAL OF LIPID RESEARCH

The farnesoid X receptor regulates transcription of 3β-hydroxysteroid dehydrogenase type 2 in human adrenal cells

(2008) Yewei Xing et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Immunolocalization of farnesoid X receptor (FXR) in mouse tissues using tissue microarray

(2007) Hiroyuki Higashiyama et al.   ACTA HISTOCHEMICA