FXR in the dorsal vagal complex is sufficient and necessary for upper small intestinal microbiome-mediated changes of TCDCA to alter insulin action in rats

Central KATP Channels Modulate Glucose Effectiveness in Humans and Rodents

(2020) Michelle Carey et al.   DIABETES

A hindbrain inhibitory microcircuit mediates vagally-coordinated glucose regulation

(2019) Carie R. Boychuk et al.   Scientific Reports

Systemic bile acids induce insulin resistance in a TGR5-independent manner

(2019) Kristen E Syring et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lactobacillus gasseri in the Upper Small Intestine Impacts an ACSL3-Dependent Fatty Acid-Sensing Pathway Regulating Whole-Body Glucose Homeostasis

(2018) Paige V. Bauer et al.   Cell Metabolism

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

Diet-induced obesity and weight loss alter bile acid concentrations and bile acid–sensitive gene expression in insulin target tissues of C57BL/6J mice

(2017) Michael R. La Frano et al.   NUTRITION RESEARCH

Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action

(2017) Beatrice M. Filippi et al.   Cell Reports

Characterization of Bile Salt Hydrolase from Lactobacillus gasseri FR4 and Demonstration of Its Substrate Specificity and Inhibitory Mechanism Using Molecular Docking Analysis

(2017) Rizwana Parveen Rani et al.   Frontiers in Microbiology

Bile Acid Signaling Pathways from the Enterohepatic Circulation to the Central Nervous System

(2017) Kim L. Mertens et al.   Frontiers in Neuroscience

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Identification of functional farnesoid X receptors in brain neurons

(2016) Chao Huang et al.   FEBS LETTERS

Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity

(2016) Jessica T. Y. Yue et al.   Nature Communications

Suppression of the HPA Axis During Cholestasis Can Be Attributed to Hypothalamic Bile Acid Signaling

(2015) Matthew McMillin et al.   MOLECULAR ENDOCRINOLOGY

Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network

(2015) Clémence D Côté et al.   NATURE MEDICINE

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

(2015) Mohamed-Sami Trabelsi et al.   Nature Communications

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

Extensive Identification of Bacterial Riboflavin Transporters and Their Distribution across Bacterial Species

(2015) Ana Gutiérrez-Preciado et al.   PLoS One

cAMP-dependent insulin modulation of synaptic inhibition in neurons of the dorsal motor nucleus of the vagus is altered in diabetic mice

(2014) Camille B. Blake et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Central Insulin Administration Improves Whole-Body Insulin Sensitivity via Hypothalamus and Parasympathetic Outputs in Men

(2014) M. Heni et al.   DIABETES

Intranasal Insulin Suppresses Endogenous Glucose Production in Humans Compared With Placebo in the Presence of Similar Venous Insulin Concentrations

(2014) Satya Dash et al.   DIABETES

Fasting Serum Taurine-Conjugated Bile Acids Are Elevated in Type 2 Diabetes and Do Not Change With Intensification of Insulin

(2014) Marlene Wewalka et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bacterial Bile Metabolising Gene Abundance in Crohn's, Ulcerative Colitis and Type 2 Diabetes Metagenomes

(2014) Alain Labbé et al.   PLoS One

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Human Insulin Resistance Is Associated With Increased Plasma Levels of 12 -Hydroxylated Bile Acids

(2013) R. A. Haeusler et al.   DIABETES

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Insulin reduces excitation in gastric-related neurons of the dorsal motor nucleus of the vagus

(2012) Camille B. Blake et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Lipid Sensing and Insulin Resistance in the Brain

(2012) Jessica T.Y. Yue et al.   Cell Metabolism

Insulin Activates Erk1/2 Signaling in the Dorsal Vagal Complex to Inhibit Glucose Production

(2012) Beatrice M. Filippi et al.   Cell Metabolism

Bile Acids Acutely Stimulate Insulin Secretion of Mouse  -Cells via Farnesoid X Receptor Activation and KATP Channel Inhibition

(2012) M. Dufer et al.   DIABETES

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass

(2012) M. Simonen et al.   OBESITY SURGERY

Activation of KATP channels suppresses glucose production in humans

(2011) Preeti Kishore et al.   JOURNAL OF CLINICAL INVESTIGATION