Article
Cell Biology
Fei Li, Yifan Zhang, Zhoujun Lin, Lizhong Yan, Qiao Liu, Yin Li, Xiaolin Pei, Ya Feng, Xiao Han, Juan Yang, Fangxu Zheng, Tianjiao Li, Yupeng Zhang, Zhenkun Fu, Di Shao, Jane Yu, Chenggang Li
Summary: This study identified rapamycin-insensitive sphingosine metabolic signatures in LAM cells and demonstrated that therapeutic targeting of aberrant SPHK1/S1P/S1PR3 signaling may have potent therapeutic benefit for patients with TSC/LAM or other hyperactive mTOR neoplasms with autophagy inhibition.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Lauriane Relav, Mabrouka Doghman-Bouguerra, Carmen Ruggiero, Joao C. D. Muzzi, Bonald C. C. Figueiredo, Enzo Lalli
Summary: Steroidogenic factor-1 (SF-1) is a nuclear receptor transcription factor that regulates adrenal and gonadal development and function. It is involved in various processes including steroid synthesis and cell survival. SF-1 expression is restricted to the hypothalamic-pituitary axis and steroidogenic organs. Changes in SF-1 expression can lead to disorders in organogenesis and function, and SF-1 overexpression is associated with adrenal cortex carcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Elia Paradiso, Clara Lazzaretti, Samantha Sperduti, Francesco Antoniani, Giulia Fornari, Giulia Brigante, Giulia Di Rocco, Simonetta Tagliavini, Tommaso Trenti, Daria Morini, Angela Immacolata Falbo, Maria Teresa Villani, Jerzy-Roch Nofer, Manuela Simoni, Francesco Poti, Livio Casarini
Summary: This study demonstrates that SIP may induce cAMP-independent activation of pCREB in granulosa cells, although this is insufficient to induce intracellular steroidogenic signals and progesterone synthesis. The activation of S1P-S1PR axis may cooperate with gonadotropins in modulating follicle development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong
Summary: SPHK1 is a conserved lipid enzyme that catalyzes the formation of S1P, and has been implicated in oncogenic functions, particularly in breast cancer. Recent evidence suggests a role for SPHK1 in regulating CSCs, indicating the therapeutic potential of targeting SPHK1 in refractory cancers enriched with CSCs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Virology
Lu Zhang, Juan Liu, Erya Xiao, Qingzhen Han, Lin Wang
Summary: Viruses can create a unique cellular environment that facilitates replication and transmission. The SphK/S1P axis plays a crucial role in regulating cellular activities during viral infections. Depending on the type of virus, the SphK/S1P axis can have pro- or anti-viral activities through the host immune system or intracellular signaling pathways and cell proliferation.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Endocrinology & Metabolism
David Montefusco, Maryam Jamil, Melissa A. Maczis, William Schroeder, Moshe Levi, Suman Ranjit, Jeremy Allegood, Dipankar Bandyopadhyay, Reuben Retnam, Sarah Spiegel, L. Ashley Cowart
Summary: Men with NAFLD are more likely to progress to NASH and liver fibrosis than women. This study revealed a novel pathway involving estrogen-mediated cross-talk between hepatocytes and HSCs that may contribute to sex differences in NAFLD through the anti-fibrogenic function of the S1P/S1PR3 axis.
MOLECULAR METABOLISM
(2022)
Review
Oncology
Saida Mebarek, Najwa Skafi, Leyre Brizuela
Summary: Prostate cancer is the second most common cancer in men worldwide, with the majority of patients being above 65. Sphingosine 1-phosphate (S1P) is a bioactive lipid that plays a crucial role in the oncogenesis of prostate cancer. S1P metabolism and its enzymes have been extensively studied in relation to prostate cancer development and potential therapeutic targets. This review summarizes the significant findings and the current progress in targeting S1P metabolism for prostate cancer treatment.
Article
Obstetrics & Gynecology
Caterina Bernacchioni, Pasquapina Ciarmela, Valentina Vannuzzi, Stefania Greco, Silvia Vannuccini, Francesca Malentacchi, Pamela Pellegrino, Tommaso Capezzuoli, Flavia Sorbi, Francesca Cencetti, Paola Bruni, Chiara Donati, Felice Petraglia
Summary: The study revealed that S1P signaling is dysregulated in uterine fibroids and involved in activin A-induced fibrosis, presenting new perspectives for the treatment of uterine fibroids.
FERTILITY AND STERILITY
(2021)
Article
Medicine, Research & Experimental
Hui Yan, Hu Zhao, Shao-wei Yi, Hang Zhuang, Dao-wen Wang, Jian-gang Jiang, Gui-fen Shen
Summary: The objective of this study was to investigate whether sphingosine-1-phosphate (S1P) could prevent cardiac remodeling and the associated mechanisms. The results demonstrated that S1P treatment improved cardiac function and reduced cardiac fibrosis in a mouse model of transverse aortic constriction (TAC). The study also identified sphingosine kinase 2 (SphK2) and the S1P receptor 2 (S1PR2)/extracellular regulated protein kinases (ERK) pathway as potential mediators of the anti-remodeling effect of S1P on the heart.
CURRENT MEDICAL SCIENCE
(2022)
Article
Cell Biology
Joseph L. Wilkerson, Sandip K. Basu, Megan A. Stiles, Amanda Prislovsky, Richard C. Grambergs, Sarah E. Nicholas, Dimitrios Karamichos, Jeremy C. Allegood, Richard L. Proia, Nawajes Mandal
Summary: The role of sphingosine kinase 1 (SphK1) in corneal neovascularization (NV) was investigated. The study showed that ablation of SphK1 can significantly reduce NV invasion in the cornea following injury. Furthermore, sphingolipid analysis revealed lower levels in Sphk1(-/-) corneas after injury.
Article
Cell Biology
Chiara D'Aprile, Simona Prioni, Laura Mauri, Alessandro Prinetti, Sara Grassi
Summary: Lipid rafts are specialized membrane domains enriched in gangliosides, sphingomyelin, cholesterol, and proteins involved in signal transduction, modulating cell homeostasis. Sphingosine 1-phosphate participates in various signal transduction processes, with enzymes and receptors often localized in lipid rafts.
CELLULAR SIGNALLING
(2021)
Article
Dentistry, Oral Surgery & Medicine
Nader Hamdan, Anjali Y. Bhagirath, Eraldo L. Batista
Summary: This study evaluated the changes in Sphingosine-1-Phosphate (S1P) levels and Sphingosine Kinase (SPHK) activity in response to non-surgical periodontal treatment. The results showed that non-surgical treatment led to a decrease in SPHK activity and S1P levels, which correlated with improvements in periodontal parameters. Specifically, SPHK1 levels significantly decreased after periodontal treatment.
Article
Oncology
Vikas Satyananda, Masanori Oshi, Yoshihisa Tokumaru, Aparna Maiti, Nitai Hait, Ryusei Matsuyama, Itaru Endo, Kazuaki Takabe
Summary: High S1P export, driven by the simultaneous high expression of SphK1 and ABCC1, is associated with enhanced HCC progression and immune response, leading to significantly worse disease-specific survival and overall survival outcomes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biology
Mengqiao Cui, Verena Gobel, Hongjie Zhang
Summary: Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite that functions as a signaling molecule in various cellular processes, with a crucial role in organ morphogenesis. Research has shown the complexity and importance of S1P signaling mechanisms and functions, expanding our understanding of the multifaceted role of S1P-dependent pathways in organ structure development and function maintenance.
BIOLOGICAL REVIEWS
(2022)
Article
Cell Biology
Yasuo Okamoto, Keisuke Kitakaze, Yasuhiro Takenouchi, Shinya Yamamoto, Hironobu Ishimaru, Kazuhito Tsuboi
Summary: The study highlights the crucial role of S1P(2) in the activation of STAT6 in macrophages, with its signaling pathway involving the Rho-Rho kinase pathway. Knockout of S1P(2) weakened the IL-4/IL-13-induced phosphorylation of STAT6 and mRNA expression of the M2 marker ARG1.
CELLULAR SIGNALLING
(2021)
Review
Biochemistry & Molecular Biology
Verena Theiler-Schwetz, Alex Zaufel, Hansjoerg Schlager, Barbara Obermayer-Pietsch, Peter Fickert, Gernot Zollner
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2019)
Article
Endocrinology & Metabolism
Felix Aberer, Julia K. Mader, Julia Holzgruber, Christian Trummer, Verena Schwetz, Marlene Pandis, Peter N. Pferschy, Hildegard Greinix, Norbert J. Tripolt, Thomas R. Pieber, Armin Zebisch, Heinz Sill, Albert Woelfler, Harald Sourij
JOURNAL OF DIABETES INVESTIGATION
(2019)
Article
Nutrition & Dietetics
Elisabeth Lerchbaum, Christian Trummer, Verena Theiler-Schwetz, Martina Kollmann, Monika Woelfler, Annemieke C. Heijboer, Stefan Pilz, Barbara Obermayer-Pietsch
EUROPEAN JOURNAL OF NUTRITION
(2019)
Article
Nutrition & Dietetics
Christian Trummer, Verena Theiler-Schwetz, Martina Kollmann, Monika Woelfler, Julia Muenzker, Stefan Pilz, Thomas R. Pieber, Annemieke C. Heijboer, Barbara Obermayer-Pietsch, Elisabeth Lerchbaum
CLINICAL NUTRITION
(2020)
Article
Nutrition & Dietetics
Elisabeth Lerchbaum, Christian Trummer, Verena Theiler-Schwetz, Martina Kollmann, Monika Woelfler, Stefan Pilz, Barbara Obermayer-Pietsch
Article
Medicine, General & Internal
Olivia Trummer, Natascha Schweighofer, Christoph W. Haudum, Christian Trummer, Stefan Pilz, Verena Theiler-Schwetz, Martin H. Keppel, Martin Gruebler, Thomas R. Pieber, Wilfried Renner, Barbara Obermayer-Pietsch, Elisabeth Lerchbaum
JOURNAL OF CLINICAL MEDICINE
(2020)
Letter
Cardiac & Cardiovascular Systems
Stefan Pilz, Verena Theiler-Schwetz, Christian Trummer
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2020)
Article
Multidisciplinary Sciences
Felix Aberer, Verena Theiler-Schwetz, Haris Ziko, Bettina Hausegger, Iris Wiederstein-Grasser, Daniel A. Hochfellner, Philipp Eller, Georg Tomberger, Martin Ellmerer, Julia K. Mader, Vladimir Bubalo
SCIENTIFIC REPORTS
(2020)
Article
Endocrinology & Metabolism
Eva Steinberger, Stefan Pilz, Christian Trummer, Verena Theiler-Schwetz, Markus Reichhartinge, Thomas Benninger, Marlene Pandis, Oliver Malle, Martin H. Keppel, Nicolas Verheyen, Martin R. Grubler, Jakob Voelkl, Andreas Meinitzer, Winfried Marz
HORMONE AND METABOLIC RESEARCH
(2020)
Correction
Endocrinology & Metabolism
Eva Steinberger, Stefan Pilz, Christian Trummer, Verena Theiler-Schwetz, Markus Reichhartinger, Thomas Benninger, Marlene Pandis, Oliver Malle, Martin H. Keppel, Nicolas Verheyen, Martin R. Gruebler, Jakob Voelkl, Andreas Meinitzer, Winfried Maerz
HORMONE AND METABOLIC RESEARCH
(2020)
Article
Cell Biology
Katrin Panzitt, Gernot Zollner, Hanns-Ulrich Marschall, Martin Wagner
Summary: The bile acid receptor FXR is considered as an important drug target for chronic cholestatic and metabolic liver diseases. Activation of FXR in the liver and intestine has different effects on metabolism. There is still debate about whether selective activation of intestinal FXR is advantageous and how to limit FXR activation to reduce side effects.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
Angela E. Dean, Emilian Jungwirth, Katrin Panzitt, Martin Wagner, Sayeepriyadarshini Anakk
Summary: In this study, it was found that hepatic Fxr is necessary for the maintenance of ductular reaction and accumulation of bile plugs. Moreover, Fxr plays an important role in regulating the expression of heme biosynthetic genes. Modulating FXR activity in EPP patients may help alleviate the associated liver disease.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Emilian Jungwirth, Katrin Panzitt, Hanns-Ulrich Marschall, Gerhard G. Thallinger, Martin Wagner
Summary: The FXR receptor plays an important role in controlling gene regulation in metabolic pathways and is a potential drug target for liver diseases. A meta-analysis of FXR binding data across species revealed modest overlap, with a consolidated murine FXR binding atlas enhancing understanding of FXR signaling capabilities. This could provide a basis for developing new drugs targeting FXR in liver diseases.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Christian Trummer, Hannes Reiher, Verena Theiler-Schwetz, Marlene Pandis, Christian Gstettner, Peter Potzinger, Tilman Keck, Thomas R. Pieber, Sigurd Lax, Johannes Haybaeck, Vinzenz Stepan, Stefan Pilz
EUROPEAN THYROID JOURNAL
(2020)