Mass spectrometric studies of the variety of beta‐amyloid proteoforms in Alzheimer's disease

The Dynamics of β-Amyloid Proteoforms Accumulation in the Brain of a 5xFAD Mouse Model of Alzheimer’s Disease

(2021) Anna E. Bugrova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Histidine-Lacked Aβ(1–16) Peptides: pH-Dependent Conformational Changes in Metal Ion Binding

(2020) Laura Habasescu et al.   International Journal of Peptide Research and Therapeutics

Relative Quantitation of Beta-Amyloid Peptide Isomers with Simultaneous Isomerization of Multiple Aspartic Acid Residues by Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry

(2020) Daniil G. Ivanov et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Current understanding of metal ions in the pathogenesis of Alzheimer’s disease

(2020) Lu Wang et al.   Translational Neurodegeneration

Computational Analysis of Alzheimer Amyloid Plaque Composition in 2D- and Elastically Reconstructed 3D-MALDI MS Images

(2020) Thomas Enzlein et al.   ANALYTICAL CHEMISTRY

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

(2019) Masaya Ikegawa et al.   Jove-Journal of Visualized Experiments

Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1-40 deposition underlies plaque polymorphism in progressing Alzheimer’s disease pathology

(2019) Wojciech Michno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coimmunocapture and Electrochemical Quantitation of Total and Phosphorylated Amyloid-β40 Monomers

(2019) Zhenzhen Yin et al.   ANALYTICAL CHEMISTRY

Evaluation of MALDI-TOF/TOF Mass Spectrometry Approach for Quantitative Determination of Aspartate Residue Isomerization in the Amyloid-β Peptide

(2019) Stanislav I. Pekov et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Molecular structure of an N-terminal phosphorylated β-amyloid fibril

(2019) Zhi-Wen Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual strategy for reduced signal suppression effects in MALDI mass spectrometry imaging

(2019) Joakim Bastrup et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Spontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer’s Disease

(2019) Tyler R. Lambeth et al.   ACS Central Science

Probabilistic model applied to ion abundances in product-ion spectra: quantitative analysis of aspartic acid isomerization in peptides

(2019) Daniil G. Ivanov et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in a transgenic mouse model of Alzheimer’s disease

(2019) Wojciech Michno et al.   JOURNAL OF NEUROCHEMISTRY

Shedding Light on the Molecular Pathology of Amyloid Plaques in Transgenic Alzheimer’s Disease Mice Using Multimodal MALDI Imaging Mass Spectrometry

(2018) Ibrahim Kaya et al.   ACS Chemical Neuroscience

Direct Evidence of the Presence of Cross-Linked Aβ Dimers in the Brains of Alzheimer’s Disease Patients

(2018) Aurelio Vázquez de la Torre et al.   ANALYTICAL CHEMISTRY

The Unexpected Role of Aβ1-42 Monomers in the Pathogenesis of Alzheimer’s Disease

(2018) Elena Tamagno et al.   JOURNAL OF ALZHEIMERS DISEASE

Metals and Alzheimer’s Disease: How Far Have We Come in the Clinic?

(2018) Paul A. Adlard et al.   JOURNAL OF ALZHEIMERS DISEASE

Detection of Amyloid Beta (Aβ) Oligomeric Composition Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS)

(2018) Jasmine S.-H. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Mass spectrometry is a multifaceted weapon to be used in the battle against Alzheimer's disease: Amyloid beta peptides and beyond

(2018) Giuseppe Grasso   MASS SPECTROMETRY REVIEWS

High performance plasma amyloid-β biomarkers for Alzheimer’s disease

(2018) Akinori Nakamura et al.   NATURE

N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer’s disease

(2018) Elena V. Kugaevskaya et al.   Scientific Reports

Amyloid-β with isomerized Asp7 cytotoxicity is coupled to protein phosphorylation

(2018) O. G. Zatsepina et al.   Scientific Reports

Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease

(2018) Maria Luisa Moro et al.   Acta Neuropathologica Communications

Mass spectrometry analysis of the diversity of Aβ peptides: difficulties and future perspectives for AD biomarker discovery

(2018) Natalia V. Zakharova et al.   Expert Review of Proteomics

Optimized Protocol for Amyloid-β Extraction from the Brain

(2018) María Izco et al.   JOURNAL OF ALZHEIMERS DISEASE

A Selected Reaction Monitoring (SRM)-Based Method for Absolute Quantification of Aβ38, Aβ40, and Aβ42 in Cerebrospinal Fluid of Alzheimer's Disease Patients and Healthy Controls

(2018) Josef Pannee et al.   JOURNAL OF ALZHEIMERS DISEASE

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Phosphorylation of the Amyloid-Beta Peptide Inhibits Zinc-Dependent Aggregation, Prevents Na,K-ATPase Inhibition, and Reduces Cerebral Plaque Deposition

(2018) Evgeny P. Barykin et al.   Frontiers in Molecular Neuroscience

Analysis of post-translational modifications in Alzheimer's disease by mass spectrometry

(2018) Andrea Renee Kelley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic

(2018) Harald Hampel et al.   Nature Reviews Neurology

Alzheimer's disease: The right drug, the right time

(2018) Todd E. Golde et al.   SCIENCE

Application of MALDI-TOF/TOF-MS for relative quantitation of α- and β-Asp7 isoforms of amyloid-β peptide

(2017) Stanislav Pekov et al.   EUROPEAN JOURNAL OF MASS SPECTROMETRY

An UHPLC–MS/MS method for simultaneous quantification of human amyloid beta peptides Aβ1-38, Aβ1-40 and Aβ1-42 in cerebrospinal fluid using micro-elution solid phase extraction

(2017) Ping-ping Lin et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Phosphorylation of a full length amyloid-β peptide modulates its amyloid aggregation, cell binding and neurotoxic properties

(2017) Elaheh Jamasbi et al.   Molecular BioSystems

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

(2017) Jun Wang et al.   Nature Reviews Neurology

APP/Aβ structural diversity and Alzheimer's disease pathogenesis

(2017) Alex E. Roher et al.   NEUROCHEMISTRY INTERNATIONAL

Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain

(2017) Norelle C. Wildburger et al.   Scientific Reports

Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity

(2016) Sathish Kumar et al.   ACTA NEUROPATHOLOGICA

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Mildly acidic conditions eliminate deamidation artifact during proteolysis: digestion with endoprotease Glu-C at pH 4.5

(2016) Shanshan Liu et al.   AMINO ACIDS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Distinguishing Aspartic and Isoaspartic Acids in Peptides by Several Mass Spectrometric Fragmentation Methods

(2016) Nick DeGraan-Weber et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Phosphorylation modifies the molecular stability of β-amyloid deposits

(2016) Nasrollah Rezaei-Ghaleh et al.   Nature Communications

Interplay of histidine residues of the Alzheimer’s disease Aβ peptide governs its Zn-induced oligomerization

(2016) Andrey N. Istrate et al.   Scientific Reports

Plasma β-amyloid in Alzheimer’s disease and vascular disease

(2016) Shorena Janelidze et al.   Scientific Reports

Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease

(2015) K. Rajasekhar et al.   CHEMICAL COMMUNICATIONS

Quantitative detection of amyloid-β peptides by mass spectrometry: state of the art and clinical applications

(2015) Pauline Bros et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Amyloid-β as a biomarker for Alzheimer’s disease: quantification methods in body fluids

(2015) Sara Galozzi et al.   Expert Review of Proteomics

Brain Amyloid-Beta Fragment Signatures in Pathological Ageing and Alzheimer's Disease by Hybrid Immunoprecipitation Mass Spectrometry

(2015) Erik Portelius et al.   Neurodegenerative Diseases

Simulations of monomeric amyloid β-peptide (1–40) with varying solution conditions and oxidation state of Met35: Implications for aggregation

(2014) Anne M. Brown et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer’s disease

(2014) Ajeet Rijal Upadhaya et al.   BRAIN

Mass Spectrometry-Based Candidate Reference Measurement Procedure for Quantification of Amyloid-  in Cerebrospinal Fluid

(2014) A. Leinenbach et al.   CLINICAL CHEMISTRY

Advances in the therapy of Alzheimer’s disease: targeting amyloid beta and tau and perspectives for the future

(2014) Harald Hampel et al.   Expert Review of Neurotherapeutics

Phosphorylation of Ser8 promotes zinc-induced dimerization of the amyloid-β metal-binding domain

(2014) Alexandra A. Kulikova et al.   Molecular BioSystems

The amyloid-β degradation pattern in plasma—A possible tool for clinical trials in Alzheimer's disease

(2014) Josef Pannee et al.   NEUROSCIENCE LETTERS

Identification and quantification of amyloid beta-related peptides in human plasma using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

(2014) Naoki KANEKO et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

A quantitative analysis of spontaneous isoaspartate formation from N-terminal asparaginyl and aspartyl residues

(2013) Bert H.-O. Güttler et al.   AMINO ACIDS

Simultaneous Determination of Post-Translational Racemization and Isomerization of N-Terminal Amyloid-β in Alzheimer’s Brain Tissues by Covalent Chiral Derivatized Ultraperformance Liquid Chromatography Tandem Mass Spectrometry

(2013) Koichi Inoue et al.   ANALYTICAL CHEMISTRY

Peripherally Applied Synthetic Peptide isoAsp7-Aβ(1-42) Triggers Cerebral β-Amyloidosis

(2013) S. A. Kozin et al.   NEUROTOXICITY RESEARCH

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

Determination of Deamidation Artifacts Introduced by Sample Preparation Using 18O-Labeling and Tandem Mass Spectrometry Analysis

(2012) Yi Du et al.   ANALYTICAL CHEMISTRY

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Phosphorylation of Amyloid-β Peptide at Serine 8 Attenuates Its Clearance via Insulin-degrading and Angiotensin-converting Enzymes

(2012) Sathish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal fluid

(2012) Gunnar Brinkmalm et al.   JOURNAL OF MASS SPECTROMETRY

Longitudinal plasma amyloid beta as a biomarker of Alzheimer’s disease

(2012) Robert A. Rissman et al.   JOURNAL OF NEURAL TRANSMISSION

When is Mass Spectrometry Combined with Affinity Approaches Essential? A Case Study of Tyrosine Nitration in Proteins

(2012) Brînduşa-Alina Petre et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Differentiation of isomeric amino acid residues in proteins and peptides using mass spectrometry

(2012) Pilar Perez Hurtado et al.   MASS SPECTROMETRY REVIEWS

Quantitation of amyloid beta peptides Aβ1–38, Aβ1–40, and Aβ1–42 in human cerebrospinal fluid by ultra-performance liquid chromatography–tandem mass spectrometry

(2011) Mary E. Lame et al.   ANALYTICAL BIOCHEMISTRY

Capabilities of MS for Analytical Quantitative Determination of the Ratio of α- and βAsp7 Isoforms of the Amyloid-β Peptide in Binary Mixtures

(2011) Maria I. Indeykina et al.   ANALYTICAL CHEMISTRY

Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders

(2011) Mathias Jucker et al.   ANNALS OF NEUROLOGY

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

(2011) Sathish Kumar et al.   EMBO JOURNAL

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid  -peptides in human cerebrospinal fluid

(2011) A. Halim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease

(2010) Erik Portelius et al.   ACTA NEUROPATHOLOGICA

Iowa Variant of Familial Alzheimer’s Disease

(2010) Yasushi Tomidokoro et al.   AMERICAN JOURNAL OF PATHOLOGY

Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies

(2009) Tamas Revesz et al.   ACTA NEUROPATHOLOGICA

Identification of Aspartic and Isoaspartic Acid Residues in Amyloid β Peptides, Including Aβ1−42, Using Electron−Ion Reactions

(2009) Nadezda P. Sargaeva et al.   ANALYTICAL CHEMISTRY

Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry

(2009) Jeffrey N. Anker et al.   Journal of Physical Chemistry C

Immunotherapy Reduces Vascular Amyloid-  in PDAPP Mice

(2008) S. Schroeter et al.   JOURNAL OF NEUROSCIENCE

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Solid-phase extraction enhances detection of beta-amyloid peptides in plasma and enables Aβ quantification following passive immunization with Aβ antibodies

(2007) Thomas A. Lanz et al.   JOURNAL OF NEUROSCIENCE METHODS