Amyloid-β as a biomarker for Alzheimer’s disease: quantification methods in body fluids

Brain Amyloid-Beta Fragment Signatures in Pathological Ageing and Alzheimer's Disease by Hybrid Immunoprecipitation Mass Spectrometry

(2015) Erik Portelius et al.   Neurodegenerative Diseases

MS-based methods for biomarkers of Parkinson's disease: what is the future?

(2015) Katalin Barkovits et al.   Bioanalysis

Detection and quantification of plasma amyloid-β by selected reaction monitoring mass spectrometry

(2014) Jun Seok Kim et al.   ANALYTICA CHIMICA ACTA

Mass Spectrometry-Based Candidate Reference Measurement Procedure for Quantification of Amyloid-  in Cerebrospinal Fluid

(2014) A. Leinenbach et al.   CLINICAL CHEMISTRY

Phosphorylation of Ser8 promotes zinc-induced dimerization of the amyloid-β metal-binding domain

(2014) Alexandra A. Kulikova et al.   Molecular BioSystems

The amyloid-β degradation pattern in plasma—A possible tool for clinical trials in Alzheimer's disease

(2014) Josef Pannee et al.   NEUROSCIENCE LETTERS

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage

(2014) Erik Portelius et al.   Alzheimers Research & Therapy

A review of β-amyloid neuroimaging in Alzheimer's disease

(2014) Paul A. Adlard et al.   Frontiers in Neuroscience

N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits

(2013) Yvonne Bouter et al.   ACTA NEUROPATHOLOGICA

CSF biomarker variability in the Alzheimer's Association quality control program

(2013) Niklas Mattsson et al.   Alzheimers & Dementia

Developing novel blood-based biomarkers for Alzheimer's disease

(2013) Heather M. Snyder et al.   Alzheimers & Dementia

Amyloid-beta isoform metabolism quantitation by stable isotope-labeled kinetics

(2013) Kwasi G. Mawuenyega et al.   ANALYTICAL BIOCHEMISTRY

Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum

(2013) Bryan Krastins et al.   CLINICAL BIOCHEMISTRY

Peripherally Applied Synthetic Peptide isoAsp7-Aβ(1-42) Triggers Cerebral β-Amyloidosis

(2013) S. A. Kozin et al.   NEUROTOXICITY RESEARCH

Inflammatory Proteins in Plasma Are Associated with Severity of Alzheimer’s Disease

(2013) Rufina Leung et al.   PLoS One

Biomarkers of Alzheimer's disease: The present and the future

(2013) S. Lehmann et al.   REVUE NEUROLOGIQUE

CSF biomarkers cutoffs: the importance of coincident neuropathological diseases

(2012) Jon B. Toledo et al.   ACTA NEUROPATHOLOGICA

Association Study of Clusterin Polymorphism rs11136000 With Late Onset Alzheimer’s Disease in Chinese Han Population

(2012) Jian-Fang Ma et al.   American Journal of Alzheimers Disease and Other Dementias

β-Amyloid Dynamics in Human Plasma

(2012) Yafei Huang et al.   ARCHIVES OF NEUROLOGY

Reference measurement procedures for Alzheimer’s disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid β42

(2012) Niklas Mattsson et al.   Biomarkers in Medicine

Novel AβIsoforms in Alzheimer's Disease - Their Role in Diagnosis and Treatment

(2012) Erik Portelius et al.   CURRENT PHARMACEUTICAL DESIGN

Stability of amyloid-β peptides in plasma and serum

(2012) Mirko Bibl et al.   ELECTROPHORESIS

Longitudinal plasma amyloid beta as a biomarker of Alzheimer’s disease

(2012) Robert A. Rissman et al.   JOURNAL OF NEURAL TRANSMISSION

Multiplexing and multivariate analysis in neurodegeneration

(2012) Ulf Andreasson et al.   METHODS

Aβ Toxicity in Alzheimer's Disease

(2012) Virve Cavallucci et al.   MOLECULAR NEUROBIOLOGY

Selected reaction monitoring–based proteomics: workflows, potential, pitfalls and future directions

(2012) Paola Picotti et al.   NATURE METHODS

MRM-based multiplexed quantitation of 67 putative cardiovascular disease biomarkers in human plasma

(2012) Dominik Domanski et al.   PROTEOMICS

Factors affecting Aβ plasma levels and their utility as biomarkers in ADNI

(2011) Jon B. Toledo et al.   ACTA NEUROPATHOLOGICA

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Clifford R. Jack et al.   Alzheimers & Dementia

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

A new methodology for simultaneous quantification of total-Aβ, Aβx-38, Aβx-40, and Aβx-42 by column-switching LC/MS/MS

(2011) Ken-ichi Watanabe et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Quantitation of amyloid beta peptides Aβ1–38, Aβ1–40, and Aβ1–42 in human cerebrospinal fluid by ultra-performance liquid chromatography–tandem mass spectrometry

(2011) Mary E. Lame et al.   ANALYTICAL BIOCHEMISTRY

Capabilities of MS for Analytical Quantitative Determination of the Ratio of α- and βAsp7 Isoforms of the Amyloid-β Peptide in Binary Mixtures

(2011) Maria I. Indeykina et al.   ANALYTICAL CHEMISTRY

Tau and p-tau as CSF biomarkers in dementia: a meta-analysis

(2011) Argonde C. van Harten et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Selected reaction monitoring applied to proteomics

(2011) Sebastien Gallien et al.   JOURNAL OF MASS SPECTROMETRY

Polymeric Complements to the Alzheimer's Disease Biomarker β-Amyloid Isoforms Aβ1–40 and Aβ1–42 for Blood Serum Analysis under Denaturing Conditions

(2011) Javier L. Urraca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Blood-based biomarkers for Alzheimer's disease: plasma Aβ40 and Aβ42, and genetic variants

(2011) Richard Mayeux et al.   NEUROBIOLOGY OF AGING

Quantification of α-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies

(2010) Brit Mollenhauer et al.   Biomarkers in Medicine

Saliva levels of Abeta1-42 as potential biomarker of Alzheimer's disease: a pilot study

(2010) Felix Bermejo-Pareja et al.   BMC Neurology

Inter-laboratory variation in cerebrospinal fluid biomarkers for Alzheimer's disease: united we stand, divided we fall

(2010) Niklas Mattsson et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Proteomics of human cerebrospinal fluid: Discovery and verification of biomarker candidates in neurodegenerative diseases using quantitative proteomics

(2010) A.C. Kroksveen et al.   Journal of Proteomics

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

(2010) Kaj Blennow et al.   Nature Reviews Neurology

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pittsburgh Compound B Imaging and Prediction of Progression From Cognitive Normality to Symptomatic Alzheimer Disease

(2009) John C. Morris et al.   ARCHIVES OF NEUROLOGY

Cerebrospinal Fluid β-Amyloid 42 and Tau Proteins as Biomarkers of Alzheimer-Type Pathologic Changes in the Brain

(2009) Tero Tapiola et al.   ARCHIVES OF NEUROLOGY

Biological markers of amyloid β-related mechanisms in Alzheimer's disease

(2009) Harald Hampel et al.   EXPERIMENTAL NEUROLOGY

Combined CSF tau, p-tau181 and amyloid-β 38/40/42 for diagnosing Alzheimer’s disease

(2009) Volker Welge et al.   JOURNAL OF NEURAL TRANSMISSION

CSF phosphorylated tau in the diagnosis and prognosis of mild cognitive impairment and Alzheimer's disease: a meta-analysis of 51 studies

(2009) A J Mitchell   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma

(2009) Terri A Addona et al.   NATURE BIOTECHNOLOGY

Meta-analysis of CSF and MRI biomarkers for detecting preclinical Alzheimer's disease

(2009) B. Schmand et al.   PSYCHOLOGICAL MEDICINE

Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease

(2008) Alex E. Roher et al.   Alzheimers & Dementia

Selected reaction monitoring for quantitative proteomics: a tutorial

(2008) Vinzenz Lange et al.   Molecular Systems Biology

Evaluation of plasma Aβ40 and Aβ42 as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment

(2008) Oskar Hansson et al.   NEUROBIOLOGY OF AGING

Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study

(2008) O. L. Lopez et al.   NEUROLOGY

Peripheral A  subspecies as risk biomarkers of Alzheimer's disease

(2008) N. Schupf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical proteomics of the cerebrospinal fluid: Towards the discovery of new biomarkers

(2008) Stéphane Roche et al.   Proteomics Clinical Applications

Do CSF total tau, phosphorylated tau, and β-amyloid 42 help to predict progression of mild cognitive impairment to Alzheimer's disease? A systematic review and meta-analysis of the literature

(2008) Breno S. O. Diniz et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Solid-phase extraction enhances detection of beta-amyloid peptides in plasma and enables Aβ quantification following passive immunization with Aβ antibodies

(2007) Thomas A. Lanz et al.   JOURNAL OF NEUROSCIENCE METHODS