Current Trends and New Challenges in Marine Phycotoxins

Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels

(2022) Sandra Raposo-Garcia et al.   FOOD AND CHEMICAL TOXICOLOGY

An Updated Review of Tetrodotoxin and Its Peculiarities

(2022) Panagiota Katikou et al.   Marine Drugs

Diversity and regional distribution of harmful algal events along the Atlantic margin of Europe

(2021) Eileen Bresnan et al.   HARMFUL ALGAE

Marine invertebrate interactions with Harmful Algal Blooms - implications for One Health

(2021) Andrew D. Turner et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

Dynamics of the genus Ostreopsis (Gonyaulacales, Dinophyceae) in a Mediterranean fish farm

(2021) Ryhane Lounas et al.   ENVIRONMENTAL MONITORING AND ASSESSMENT

Search for potential biomarkers for saxitoxin detection

(2021) Alejandra A. Rivera et al.   TOXICOLOGY IN VITRO

Tetrodotoxin for Chemotherapy-Induced Neuropathic Pain: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Dose Finding Trial

(2021) Samuel A. Goldlust et al.   Toxins

Effects of long-term low dose saxitoxin exposure on nerve damage in mice

(2021) Qian Sun et al.   Aging-US

The diarrhetic shellfish-poisoning toxin, okadaic acid, provokes gastropathy, dysbiosis and susceptibility to bacterial infection in a non-rodent bioassay, Galleria mellonella

(2021) Helena Emery et al.   ARCHIVES OF TOXICOLOGY

Serotonin involvement in okadaic acid-induced diarrhoea in vivo

(2021) M. Carmen Louzao et al.   ARCHIVES OF TOXICOLOGY

Two new skeletal analogues of saxitoxin found in the scallop, Patinopecten yessoensis, as possible metabolites of paralytic shellfish toxins

(2021) Satoshi Numano et al.   CHEMOSPHERE

Method performance verification for the combined detection and quantitation of the marine neurotoxins cyclic imines and brevetoxin shellfish metabolites in mussels (Mytilus edulis) and oysters (Crassostrea gigas) by UHPLC-MS/MS

(2021) Alison O'Neill et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Toxicity Screening of a Gambierdiscus australes Strain from the Western Mediterranean Sea and Identification of a Novel Maitotoxin Analogue

(2021) Pablo Estevez et al.   Marine Drugs

Guidance Level for Brevetoxins in French Shellfish

(2021) Nathalie Arnich et al.   Marine Drugs

Okadaic Acid Exposure Induced Neural Tube Defects in Chicken (Gallus gallus) Embryos

(2021) Yuhu Jiao et al.   Marine Drugs

An Electrochemical Ti3C2Tx Aptasensor for Sensitive and Label-Free Detection of Marine Biological Toxins

(2021) Najeeb Ullah et al.   SENSORS

Complex profiles of azaspiracid analogues in two culture strains of Azadinium poporum (Amphidomataceae, Dinophyceae) isolated from Japanese coastal waters determined by LC-MS/MS

(2021) Mayu Ozawa et al.   TOXICON

An Update on Ciguatoxins and CTX-like Toxicity in Fish from Different Trophic Levels of the Selvagens Islands (NE Atlantic, Madeira, Portugal)

(2021) Pedro Reis Costa et al.   Toxins

Experimental Evidence of Ciguatoxin Accumulation and Depuration in Carnivorous Lionfish

(2021) Isabel do Prado Leite et al.   Toxins

Paralytic and Amnesic Shellfish Toxins Impacts on Seabirds, Analyses and Management

(2021) Begoña Ben-Gigirey et al.   Toxins

Sub-Acute Feeding Study of Saxitoxin to Mice Confirms the Effectiveness of Current Regulatory Limits for Paralytic Shellfish Toxins

(2021) Sarah C. Finch et al.   Toxins

Acute oral toxicity and tissue residues of saxitoxin in the mallard (Anas platyrhynchos)

(2021) Robert J. Dusek et al.   HARMFUL ALGAE

Chemodiversity of Brevetoxins and Other Potentially Toxic Metabolites Produced by Karenia spp. and Their Metabolic Products in Marine Organisms

(2021) Vincent Hort et al.   Marine Drugs

Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins

(2021) Rawan Mackieh et al.   Marine Drugs

Marine paralytic shellfish toxins: chemical properties, mode of action, newer analogues, and structure–toxicity relationship

(2021) Joana F. Leal et al.   NATURAL PRODUCT REPORTS

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

(2021) Kasper B. Hansen et al.   PHARMACOLOGICAL REVIEWS

Public health risks associated with chronic, low-level domoic acid exposure: A review of the evidence

(2021) Rebekah Petroff et al.   PHARMACOLOGY & THERAPEUTICS

First evidence that emerging pinnatoxin-G, a contaminant of shellfish, reaches the brain and crosses the placental barrier

(2021) Denis Servent et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Role of enteric glial cells in the toxicity of phycotoxins: Investigation with a tri-culture intestinal cell model

(2021) Océane Reale et al.   TOXICOLOGY LETTERS

Acute toxicity of decarbamoyl gonyautoxin 1&4 to mice by various routes of administration

(2021) Michael J. Boundy et al.   TOXICON

Paralytic Shellfish Poisoning (PSP) in Mussels from the Eastern Cantabrian Sea: Toxicity, Toxin Profile, and Co-Occurrence with Cyclic Imines

(2021) Tamara Rodríguez-Cabo et al.   Toxins

Digital Technologies and Open Data Sources in Marine Biotoxins’ Risk Analysis: The Case of Ciguatera Fish Poisoning

(2021) Panagiota Katikou   Toxins

Twenty-Five Years of Domoic Acid Monitoring in Galicia (NW Spain): Spatial, Temporal and Interspecific Variations

(2021) Juan Blanco et al.   Toxins

Specification of the Okadaic Acid Equivalent for Okadaic Acid, Dinophysistoxin-1, and Dinophysistoxin-2 Based on Protein Phosphatase 2A Inhibition and Cytotoxicity Assays Using Neuro 2A Cell Line

(2021) Tsuyoshi Ikehara et al.   Journal of Marine Science and Engineering

A smartphone-controlled amperometric immunosensor for the detection of Pacific ciguatoxins in fish

(2021) Mònica Campàs et al.   FOOD CHEMISTRY

Global impact of ciguatoxins and ciguatera fish poisoning on fish, fisheries and consumers

(2020) Lucía Soliño et al.   ENVIRONMENTAL RESEARCH

Neurotrophic Factors Protect the Intestinal Barrier from Rotavirus Insult in Mice

(2020) Marie Hagbom et al.   mBio

Ciguatera Fish Poisoning: The Risk from an Aotearoa/New Zealand Perspective

(2020) Lesley L. Rhodes et al.   Toxins

Acute Oral Toxicity of Pinnatoxin G in Mice

(2020) Silvio Sosa et al.   Toxins

Paralytic shellfish toxins – Call for uniform reporting units

(2020) Alison R. Turnbull et al.   TOXICON

Toxins of Okadaic Acid-Group Increase Malignant Properties in Cells of Colon Cancer

(2020) Danae Jiménez-Cárcamo et al.   Toxins

Liquid Chromatography Coupled to High-Resolution Mass Spectrometry for the Confirmation of Caribbean Ciguatoxin-1 as the Main Toxin Responsible for Ciguatera Poisoning Caused by Fish from European Atlantic Coasts

(2020) Pablo Estevez et al.   Toxins

Revisiting the Neuroblastoma Cell-Based Assay (CBA-N2a) for the Improved Detection of Marine Toxins Active on Voltage Gated Sodium Channels (VGSCs)

(2020) Jérôme Viallon et al.   Toxins

Evaluation of Matrix Issues in the Applicability of the Neuro-2a Cell Based Assay on the Detection of CTX in Fish Samples

(2020) David Castro et al.   Toxins

Oral Chronic Toxicity of the Safe Tetrodotoxin Dose Proposed by the European Food Safety Authority and Its Additive Effect with Saxitoxin

(2020) Andrea Boente-Juncal et al.   Toxins

Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K+ and Na+ Channels

(2020) Kenny M. Van Theemsche et al.   Frontiers in Pharmacology

Development of a highly sensitive detection method for TTX based on a magnetic bead-aptamer competition system under triple cycle amplification

(2020) Man Zhang et al.   ANALYTICA CHIMICA ACTA

Ciguatera fish poisoning in France: experience of the French Poison Control Centre Network from 2012 to 2019

(2020) Luc de Haro et al.   CLINICAL TOXICOLOGY

Toxic marine microalgae and noxious blooms in the Mediterranean Sea: A contribution to the Global HAB Status Report

(2020) Adriana Zingone et al.   HARMFUL ALGAE

Marine Excitatory Amino Acids: Structure, Properties, Biosynthesis and Recent Approaches to Their Syntheses

(2020) Valentin A. Stonik et al.   MOLECULES

Health risk assessment related to pinnatoxins in French shellfish

(2020) Nathalie Arnich et al.   TOXICON

OMICs Approaches in Diarrhetic Shellfish Toxins Research

(2020) Alexandre Campos et al.   Toxins

Advances in Detecting Ciguatoxins in Fish

(2020) Tibor Pasinszki et al.   Toxins

In Vivo Evaluation of the Chronic Oral Toxicity of the Marine Toxin Palytoxin

(2020) Andrea Boente-Juncal et al.   Toxins

Partial Blockade of Human Voltage-Dependent Sodium Channels by the Marine Toxins Azaspiracids

(2020) Andrea Boente-Juncal et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Changes in colonic microbiotas in rat after long-term exposure to low dose of okadaic acid

(2020) Yang Liu et al.   CHEMOSPHERE

Ciguatera poisonings: A global review of occurrences and trends

(2020) M. Chinain et al.   HARMFUL ALGAE

Volume-regulated anion channel as a novel cancer therapeutic target

(2020) Rong Xu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Epidemiology and Toxicology of Ciguatera Poisoning in the Colombian Caribbean

(2020) Roberto Navarro Quiroz et al.   Marine Drugs

Neurological Disturbances of Ciguatera Poisoning: Clinical Features and Pathophysiological Basis

(2020) Killian L’Herondelle et al.   Cells

Simple determination of six groups of lipophilic marine algal toxins in seawater by automated on-line solid phase extraction coupled to liquid chromatography-tandem mass spectrometry

(2020) Jiuming Wang et al.   CHEMOSPHERE

Effects of saxitoxins exposure on oligodendrocyte development in mouse neonates

(2020) Cesar Macedo Lima-Filho et al.   TOXICON

Industrial Applications of Dinoflagellate Phycotoxins Based on Their Modes of Action: A Review

(2020) Kichul Cho et al.   Toxins

First Report of Paralytic Shellfish Toxins in Marine Invertebrates and Fish in Spain

(2020) Begoña Ben-Gigirey et al.   Toxins

Okadaic Acid (OA): Toxicity, Detection and Detoxification,

(2019) Ling-ling Fu et al.   TOXICON

Chronic In Vivo Effects of Repeated Exposure to Low Oral Doses of Tetrodotoxin: Preliminary Evidence of Nephrotoxicity and Cardiotoxicity

(2019) Andrea Boente-Juncal et al.   Toxins

Structure Elucidation and Biological Evaluation of Maitotoxin-3, a Homologue of Gambierone, from Gambierdiscus belizeanus

(2019) Andrea Boente-Juncal et al.   Toxins

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins

(2019) Huaizong Shen et al.   SCIENCE

Voltage-gated sodium channels: structures, functions, and molecular modeling

(2019) Lei Xu et al.   DRUG DISCOVERY TODAY

Azaspiracids Increase Mitochondrial Dehydrogenases Activity in Hepatocytes: Involvement of Potassium and Chloride Ions

(2019) Marco Pelin et al.   Marine Drugs

Synthetic Pinnatoxins A and G Reversibly Block Mouse Skeletal Neuromuscular Transmission In Vivo and In Vitro

(2019) Evelyne Benoit et al.   Marine Drugs

Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin

(2019) Paula Abal et al.   Toxins

Tetrodotoxins Occurrence in Non-Traditional Vectors of the North Atlantic Waters (Portuguese Maritime Territory, and Morocco Coast)

(2019) Marisa Silva et al.   Toxins

Label-Free Direct Detection of Saxitoxin Based on a Localized Surface Plasmon Resonance Aptasensor

(2019) Su-Ji Ha et al.   Toxins

Phosphorene-gold nanocomposite based microfluidic aptasensor for the detection of okadaic acid

(2019) Saipriya Ramalingam et al.   BIOSENSORS & BIOELECTRONICS

Ocurrence of Ostreopsis in two temperate coastal bays (SW iberia): Insights from the plankton

(2019) Mariana Santos et al.   HARMFUL ALGAE

Novel Insights on the Toxicity of Phycotoxins on the Gut through the Targeting of Enteric Glial Cells

(2019) Océane Reale et al.   Marine Drugs

Pinnatoxins’ Deleterious Effects on Cholinergic Networks: From Experimental Models to Human Health

(2019) Nicolas Delcourt et al.   Marine Drugs

Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity

(2019) Chao Zhao et al.   Nature Communications

LC–MS/MS Analysis of the Emerging Toxin Pinnatoxin-G and High Levels of Esterified OA Group Toxins in Galician Commercial Mussels

(2019) Paz Otero et al.   Toxins

Molecular Determinants of Brevetoxin Binding to Voltage-Gated Sodium Channels

(2019) Keiichi Konoki et al.   Toxins

Development of Ultra-Performance Liquid Chromatography with Post-Column Fluorescent Derivatization for the Rapid Detection of Saxitoxin Analogues and Analysis of Bivalve Monitoring Samples

(2019) Watanabe et al.   Toxins

Kainic Acid-Based Agonists of Glutamate Receptors: SAR Analysis and Guidelines for Analog Design

(2019) Zhenlin Tian et al.   ACS Chemical Neuroscience

Biological Effects of the Azaspiracid-Producing Dinoflagellate Azadinium dexteroporum in Mytilus galloprovincialis from the Mediterranean Sea

(2019) Maria Elisa Giuliani et al.   Marine Drugs

Lipophilic Toxins in Galicia (NW Spain) between 2014 and 2017: Incidence on the Main Molluscan Species and Analysis of the Monitoring Efficiency

(2019) Blanco et al.   Toxins

Ciguatoxin Occurrence in Food-Web Components of a Cuban Coral Reef Ecosystem: Risk-Assessment Implications

(2019) Lisbet Díaz-Asencio et al.   Toxins

Synergistic Effect of Transient Receptor Potential Antagonist and Amiloride against Maitotoxin Induced Calcium Increase and Cytotoxicity in Human Neuronal Stem Cells

(2018) Andrea Boente-Juncal et al.   ACS Chemical Neuroscience

In Vitro Effects of Chronic Spirolide Treatment on Human Neuronal Stem Cell Differentiation and Cholinergic System Development

(2018) Andrea Boente-Juncal et al.   ACS Chemical Neuroscience

Capillary electrophoresis–tandem mass spectrometry for multiclass analysis of polar marine toxins

(2018) Daniel G. Beach et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Dynamics of paralytic shellfish toxins and their metabolites during timecourse exposure of scallops Chlamys farreri and mussels Mytilus galloprovincialis to Alexandrium pacificum

(2018) Jiangbing Qiu et al.   AQUATIC TOXICOLOGY

A biolayer interferometry-based enzyme-linked aptamer sorbent assay for real-time and highly sensitive detection of PDGF-BB

(2018) Shunxiang Gao et al.   BIOSENSORS & BIOELECTRONICS

Rapid analysis of paralytic shellfish toxins and tetrodotoxins by liquid chromatography-tandem mass spectrometry using a porous graphitic carbon column

(2018) Veronica Rey et al.   FOOD CHEMISTRY

Phylogeny, morphology and toxicity of benthic dinoflagellates of the genus Fukuyoa (Goniodomataceae, Dinophyceae) from a subtropical reef ecosystem in the South China Sea

(2018) Priscilla T.Y. Leung et al.   HARMFUL ALGAE

Identification of 21,22-Dehydroazaspiracids in Mussels (Mytilus edulis) and in Vitro Toxicity of Azaspiracid-26

(2018) Jane Kilcoyne et al.   JOURNAL OF NATURAL PRODUCTS

Comparative toxicity of dinophysistoxin-1 and okadaic acid in mice

(2018) Hodaka SUZUKI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Phycotoxins in Marine Shellfish: Origin, Occurrence and Effects on Humans

(2018) Federica Farabegoli et al.   Marine Drugs

Mixtures of Lipophilic Phycotoxins: Exposure Data and Toxicological Assessment

(2018) Jimmy Alarcan et al.   Marine Drugs

Preliminary Results on the Evaluation of the Occurrence of Tetrodotoxin Associated to Marine Vibrio spp. in Bivalves from the Galician Rias (Northwest of Spain)

(2018) Jose Leão et al.   Marine Drugs

A single run UPLC-MS/MS method for detection of all EU-Regulated marine toxins

(2018) Inés Rodríguez et al.   TALANTA

Toxic equivalency factors (TEFs) after acute oral exposure of azaspiracid 1, −2 and −3 in mice

(2018) M. Pelin et al.   TOXICOLOGY LETTERS

Accumulation and transformation of azaspiracids in scallops ( Chlamys farreri ) and mussels ( Mytilus galloprovincialis ) fed with Azadinium poporum, and response of antioxidant enzymes

(2018) Ying Ji et al.   TOXICON

EU Regulatory Risk Management of Marine Biotoxins in the Marine Bivalve Mollusc Food-Chain

(2018) Micheál O’Mahony   Toxins

Fatal Canine Intoxications Linked to the Presence of Saxitoxins in Stranded Marine Organisms Following Winter Storm Activity

(2018) Andrew Turner et al.   Toxins

Tissue Distribution and Elimination of Ciguatoxins in Tridacna maxima (Tridacnidae, Bivalvia) Fed Gambierdiscus polynesiensis

(2018) Mélanie Roué et al.   Toxins

Tectus niloticus (Tegulidae, Gastropod) as a Novel Vector of Ciguatera Poisoning: Clinical Characterization and Follow-Up of a Mass Poisoning Event in Nuku Hiva Island (French Polynesia)

(2018) Clémence Gatti et al.   Toxins

Toxic Action Reevaluation of Okadaic Acid, Dinophysistoxin-1 and Dinophysistoxin-2: Toxicity Equivalency Factors Based on the Oral Toxicity Study

(2018) Paula Abal et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Magnetic Separation-Based Multiple SELEX for Effectively Selecting Aptamers against Saxitoxin, Domoic Acid, and Tetrodotoxin

(2018) Huajie Gu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

(2018) Xiaojing Pan et al.   SCIENCE

Sensor system based on flexible screen-printed electrodes for electrochemical detection of okadaic acid in seawater

(2018) B. Molinero-Abad et al.   TALANTA

Extended Targeted and Non-Targeted Strategies for the Analysis of Marine Toxins in Mussels and Oysters by (LC-HRMS)

(2018) Inès Dom et al.   Toxins

Human Poisoning from Marine Toxins: Unknowns for Optimal Consumer Protection

(2018) Natalia Vilariño et al.   Toxins

Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies

(2018) Denis B. Tikhonov et al.   Frontiers in Pharmacology

Determination of lipophilic marine toxins in fresh and processed shellfish using modified QuEChERS and ultra-high-performance liquid chromatography–tandem mass spectrometry

(2018) Lin Wang et al.   FOOD CHEMISTRY

Pseudo-nitzschia, Nitzschia, and domoic acid: New research since 2011

(2018) Stephen S. Bates et al.   HARMFUL ALGAE

Colonocyte metabolism shapes the gut microbiota

(2018) Yael Litvak et al.   SCIENCE

Aptamers and Aptasensors for Highly Specific Recognition and Sensitive Detection of Marine Biotoxins: Recent Advances and Perspectives

(2018) Lianhui Zhao et al.   Toxins

First Report on the Occurrence of Tetrodotoxins in Bivalve Mollusks in The Netherlands

(2018) Arjen Gerssen et al.   Toxins

Two novel azaspiracids from Azadinium poporum, and a comprehensive compilation of azaspiracids produced by Amphidomataceae, (Dinophyceae)

(2018) Bernd Krock et al.   HARMFUL ALGAE

Tetrodotoxin levels of three pufferfish species (Lagocephalus sp.) caught in the North-Eastern Mediterranean sea

(2018) Ali Rıza Kosker et al.   CHEMOSPHERE

Implementation of liquid chromatography tandem mass spectrometry for the analysis of ciguatera fish poisoning in contaminated fish samples from Atlantic coasts

(2018) Pablo Estevez et al.   FOOD CHEMISTRY

Screening for the presence of lipophilic marine biotoxins in shellfish samples using the neuro-2a bioassay

(2017) Marcia Bodero et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Understanding the blob bloom: Warming increases toxicity and abundance of the harmful bloom diatom Pseudo-nitzschia in California coastal waters

(2017) Zhi Zhu et al.   HARMFUL ALGAE

Chronic low-level exposure to the common seafood toxin domoic acid causes cognitive deficits in mice

(2017) Kathi A. Lefebvre et al.   HARMFUL ALGAE

Identification of Azadinium species and a new azaspiracid from Azadinium poporum in Puget Sound, Washington State, USA

(2017) Joo-Hwan Kim et al.   HARMFUL ALGAE

Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors

(2017) Jordi Molgó et al.   JOURNAL OF NEUROCHEMISTRY

Ciguatoxins and Maitotoxins in Extracts of Sixteen Gambierdiscus Isolates and One Fukuyoa Isolate from the South Pacific and Their Toxicity to Mice by Intraperitoneal and Oral Administration

(2017) Rex Munday et al.   Marine Drugs

From Marine Venoms to Drugs: Efficiently Supported by a Combination of Transcriptomics and Proteomics

(2017) Bing Xie et al.   Marine Drugs

Guanidinium Toxins and Their Interactions with Voltage-Gated Sodium Ion Channels

(2017) Lorena Durán-Riveroll et al.   Marine Drugs

An Updated Review of Ciguatera Fish Poisoning: Clinical, Epidemiological, Environmental, and Public Health Management

(2017) Melissa Friedman et al.   Marine Drugs

Influence of environmental factors on the toxin production of Ostreopsis cf. ovata during bloom events

(2017) Stefano Accoroni et al.   MARINE POLLUTION BULLETIN

Hollow Silica Nanoparticles Penetrate the Peripheral Nerve and Enhance the Nerve Blockade from Tetrodotoxin

(2017) Qian Liu et al.   NANO LETTERS

Forty Years of Sodium Channels: Structure, Function, Pharmacology, and Epilepsy

(2017) William A. Catterall   NEUROCHEMICAL RESEARCH

Lessons from crystal structures of kainate receptors

(2017) Stine Møllerud et al.   NEUROPHARMACOLOGY

Climatic regulation of the neurotoxin domoic acid

(2017) S. Morgaine McKibben et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exposure of okadaic acid alters the angiogenesis in developing chick embryos

(2017) Yu-hu Jiao et al.   TOXICON

Presence of azaspiracids in bivalve molluscs from Northern Spain

(2017) Juan Blanco et al.   TOXICON

Sublethal doses of dinophysistoxin-1 and okadaic acid stimulate secretion of inflammatory factors on innate immune cells: Negative health consequences

(2017) Miguel del Campo et al.   TOXICON

Derivation of toxicity equivalency factors for marine biotoxins associated with Bivalve Molluscs

(2017) Luis M. Botana et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Tetrodotoxin for Moderate to Severe Cancer-Related Pain: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Trial

(2017) Neil A. Hagen et al.   Pain Research & Management

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)

(2017) Paula Abal et al.   Toxins

Biooxidation of Ciguatoxins Leads to Species-Specific Toxin Profiles

(2017) Tsuyoshi Ikehara et al.   Toxins

Acute Toxicities of the Saxitoxin Congeners Gonyautoxin 5, Gonyautoxin 6, Decarbamoyl Gonyautoxin 2&3, Decarbamoyl Neosaxitoxin, C-1&2 and C-3&4 to Mice by Various Routes of Administration

(2017) Andrew Selwood et al.   Toxins

Domoic acid: Attributes, exposure risks, innovative detection techniques and therapeutics

(2017) Abdullah F. Saeed et al.   Algal Research-Biomass Biofuels and Bioproducts

Chronic ciguatoxin poisoning causes emotional and cognitive dysfunctions in rats

(2017) Jun Wang et al.   Toxicology Research

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics

(2017) Leena Yadav et al.   Cell Systems

Analytical challenges for regulated marine toxins. Detection methods

(2017) Inés Rodríguez et al.   Current Opinion in Food Science

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1

(2017) Marco C. Inserra et al.   Scientific Reports

Identification of ciguatoxins in a shark involved in a fatal food poisoning in the Indian Ocean

(2017) Jorge Diogène et al.   Scientific Reports

Characteristic Features and Contributory Factors in Fatal Ciguatera Fish Poisoning—Implications for Prevention and Public Education

(2016) Thomas Y. K. Chan   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Marine-Derived Pharmaceuticals - Challenges and Opportunities

(2016) Ulrike Lindequist   Biomolecules & Therapeutics

Gonyautoxin 1/4 aptamers with high-affinity and high-specificity: From efficient selection to aptasensor application

(2016) Shunxiang Gao et al.   BIOSENSORS & BIOELECTRONICS

Toxicological Perspective on Climate Change: Aquatic Toxins

(2016) Luis M. Botana   CHEMICAL RESEARCH IN TOXICOLOGY

Ovatoxin-a, A Palytoxin Analogue Isolated from Ostreopsis cf. ovata Fukuyo: Cytotoxic Activity and ELISA Detection

(2016) Marco Pelin et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Glutamate in peripheral organs: Biology and pharmacology

(2016) Jie Du et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Prevalence of algal toxins in Alaskan marine mammals foraging in a changing arctic and subarctic environment

(2016) Kathi A. Lefebvre et al.   HARMFUL ALGAE

Characterization of a Strain ofFukuyoa paulensis(Dinophyceae) from the Western Mediterranean Sea

(2016) Aitor Laza-Martínez et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Ostreopsis fattorussoisp. nov. (Dinophyceae), a new benthic toxicOstreopsisspecies from the eastern Mediterranean Sea

(2016) Stefano Accoroni et al.   JOURNAL OF PHYCOLOGY

Structure–Activity Relationship Studies Using Natural and Synthetic Okadaic Acid/Dinophysistoxin Toxins

(2016) Michael Twiner et al.   Marine Drugs

Yessotoxin, a Promising Therapeutic Tool

(2016) Amparo Alfonso et al.   Marine Drugs

Subacute Cardiovascular Toxicity of the Marine Phycotoxin Azaspiracid-1 in Rats

(2016) Sara F. Ferreiro et al.   TOXICOLOGICAL SCIENCES

Ciguatoxin reduces regenerative capacity of axotomized peripheral neurons and delays functional recovery in pre-exposed mice after peripheral nerve injury

(2016) Ngan Pan Bennett Au et al.   Scientific Reports

Graphene oxide-assisted non-immobilized SELEX of okdaic acid aptamer and the analytical application of aptasensor

(2016) Huajie Gu et al.   Scientific Reports

How Safe Is Safe for Marine Toxins Monitoring?

(2016) Luis Botana et al.   Toxins

Liquid Chromatography with a Fluorimetric Detection Method for Analysis of Paralytic Shellfish Toxins and Tetrodotoxin Based on a Porous Graphitic Carbon Column

(2016) Veronica Rey et al.   Toxins

Marine Biotoxins: Occurrence, Toxicity, Regulatory Limits and Reference Methods

(2016) Pierina Visciano et al.   Frontiers in Microbiology

Yessotoxin, a Marine Toxin, Exhibits Anti-Allergic and Anti-Tumoural Activities Inhibiting Melanoma Tumour Growth in a Preclinical Model

(2016) Araceli Tobío et al.   PLoS One

Development and Validation of a Novel Lateral Flow Immunoassay (LFIA) for the Rapid Screening of Paralytic Shellfish Toxins (PSTs) from Shellfish Extracts

(2015) Waqass Jawaid et al.   ANALYTICAL CHEMISTRY

Evaluation of toxicity equivalent factors of paralytic shellfish poisoning toxins in seven human sodium channels types by an automated high throughput electrophysiology system

(2015) Eva Alonso et al.   ARCHIVES OF TOXICOLOGY

An improved sensitive assay for the detection of PSP toxins with neuroblastoma cell-based impedance biosensor

(2015) Ling Zou et al.   BIOSENSORS & BIOELECTRONICS

An improved functional assay for rapid detection of marine toxins, saxitoxin and brevetoxin using a portable cardiomyocyte-based potential biosensor

(2015) Qin Wang et al.   BIOSENSORS & BIOELECTRONICS

Ostreopsis cf. ovata dynamics in the NW Mediterranean Sea in relation to biotic and abiotic factors

(2015) Olga Carnicer et al.   ENVIRONMENTAL RESEARCH

Determination of Palytoxins in Soft Coral and Seawater from a Home Aquarium. Comparison between Palythoa- and Ostreopsis-Related Inhalatory Poisonings

(2015) Luciana Tartaglione et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Detection of the pufferfish toxin tetrodotoxin in European bivalves, England, 2013 to 2014

(2015) A Turner et al.   Eurosurveillance

Facile and Cost-Effective Detection of Saxitoxin Exploiting Aptamer Structural Switching

(2015) Karol Alfaro et al.   FOOD TECHNOLOGY AND BIOTECHNOLOGY

Harmful algal blooms and climate change: Learning from the past and present to forecast the future

(2015) Mark L. Wells et al.   HARMFUL ALGAE

Development and Validation of a Lateral Flow Immunoassay for the Rapid Screening of Okadaic Acid and All Dinophysis Toxins from Shellfish Extracts

(2015) Waqass Jawaid et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Single-Laboratory Validation of a Multitoxin Ultra-Performance LC-Hydrophilic Interaction LC-MS/MS Method for Quantitation of Paralytic Shellfish Toxins in Bivalve Shellfish

(2015) Andrew D. Turner et al.   JOURNAL OF AOAC INTERNATIONAL

New method for the analysis of lipophilic marine biotoxins in fresh and canned bivalves by liquid chromatography coupled to high resolution mass spectrometry: A quick, easy, cheap, efficient, rugged, safe approach

(2015) A. Rúbies et al.   JOURNAL OF CHROMATOGRAPHY A

Analysis of paralytic shellfish toxins, potential chemical threat agents, in food using hydrophilic interaction liquid chromatography–mass spectrometry

(2015) Daniel Jansson et al.   JOURNAL OF CHROMATOGRAPHY A

Potential Threats Posed by New or Emerging Marine Biotoxins in UK Waters and Examination of Detection Methodologies Used for Their Control: Cyclic Imines

(2015) Keith Davidson et al.   Marine Drugs

Potential Threats Posed by New or Emerging Marine Biotoxins in UK Waters and Examination of Detection Methodology Used in Their Control: Brevetoxins

(2015) Andrew Turner et al.   Marine Drugs

Tetrodotoxin, an Extremely Potent Marine Neurotoxin: Distribution, Toxicity, Origin and Therapeutical Uses

(2015) Jorge Lago et al.   Marine Drugs

Hunt for Palytoxins in a Wide Variety of Marine Organisms Harvested in 2010 on the French Mediterranean Coast

(2015) Ronel Biré et al.   Marine Drugs

Ocean impact on decadal Atlantic climate variability revealed by sea-level observations

(2015) Gerard D. McCarthy et al.   NATURE

Antihyperalgesic effect of tetrodotoxin in rat models of persistent muscle pain

(2015) P. Alvarez et al.   NEUROSCIENCE

Gambierone, a Ladder-Shaped Polyether from the Dinoflagellate Gambierdiscus belizeanus

(2015) Inés Rodríguez et al.   ORGANIC LETTERS

Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α12βγδ nAChRs

(2015) Yves Bourne et al.   STRUCTURE

Evaluation of okadaic acid, dinophysistoxin-1 and dinophysistoxin-2 toxicity on Neuro-2a, NG108-15 and MCF-7 cell lines

(2015) Lucia Soliño et al.   TOXICOLOGY IN VITRO

Diarrhetic effect of okadaic acid could be related with its neuronal action: Changes in neuropeptide Y

(2015) M. Carmen Louzao et al.   TOXICOLOGY LETTERS

Two-year study of lipophilic marine toxin profile in mussels of the North-central Adriatic Sea: First report of azaspiracids in Mediterranean seafood

(2015) Simone Bacchiocchi et al.   TOXICON

Occurrence and profiles of lipophilic toxins in shellfish harvested from Argentina

(2015) Andrew D. Turner et al.   TOXICON

New insights into the causes of human illness due to consumption of azaspiracid contaminated shellfish

(2015) O. P. Chevallier et al.   Scientific Reports

Acute Cardiotoxicity Evaluation of the Marine Biotoxins OA, DTX-1 and YTX

(2015) Sara Ferreiro et al.   Toxins

First Detection of Tetrodotoxin in Greek Shellfish by UPLC-MS/MS Potentially Linked to the Presence of the Dinoflagellate Prorocentrum minimum

(2015) Aristidis Vlamis et al.   Toxins

Different toxic effects of YTX in tumor K-562 and lymphoblastoid cell lines

(2015) Andrea Fernández-Araujo et al.   Frontiers in Pharmacology

Liquid chromatography–high-resolution mass spectrometry for palytoxins in mussels

(2014) Patrizia Ciminiello et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Simultaneous detection of microcysin-LR and okadaic acid using a dual fluorescence resonance energy transfer aptasensor

(2014) Shijia Wu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation

(2014) J. A. Rubiolo et al.   ARCHIVES OF TOXICOLOGY

Respiratory impairment in four patients associated with exposure to palytoxin containing coral

(2014) Andre Wieringa et al.   CLINICAL TOXICOLOGY

First Finding of Ostreopsis cf. ovata Toxins in Marine Aerosols

(2014) Patrizia Ciminiello et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Development of a Planar Waveguide Microarray for the Monitoring and Early Detection of Five Harmful Algal Toxins in Water and Cultures

(2014) Sara E. McNamee et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Flow Cytometric-Membrane Potential Detection of Sodium Channel Active Marine Toxins: Application to Ciguatoxins in Fish Muscle and Feasibility of Automating Saxitoxin Detection

(2014) Ronald Manger et al.   JOURNAL OF AOAC INTERNATIONAL

Development and Utilization of a Fluorescence-Based Receptor-Binding Assay for the Site 5 Voltage-Sensitive Sodium Channel Ligands Brevetoxin and Ciguatoxin

(2014) Jennifer R. McCall et al.   JOURNAL OF AOAC INTERNATIONAL

Fatal Paralytic Shellfish Poisoning in Kittlitz's Murrelet (Brachyramphus brevirostris) Nestlings, Alaska, USA

(2014) Valerie Shearn-Bochsler et al.   JOURNAL OF WILDLIFE DISEASES

Confirmation of Pinnatoxins and Spirolides in Shellfish and Passive Samplers from Catalonia (Spain) by Liquid Chromatography Coupled with Triple Quadrupole and High-Resolution Hybrid Tandem Mass Spectrometry

(2014) María García-Altares et al.   Marine Drugs

Dinophysis Toxins: Causative Organisms, Distribution and Fate in Shellfish

(2014) Beatriz Reguera et al.   Marine Drugs

Molecular and Cellular Mechanism of Okadaic Acid (OKA)-Induced Neurotoxicity: A Novel Tool for Alzheimer’s Disease Therapeutic Application

(2014) Pradip K. Kamat et al.   MOLECULAR NEUROBIOLOGY

Genus Gambierdiscus in the Canary Islands (NE Atlantic Ocean) with Description of Gambierdiscus silvae sp. nov., a New Potentially Toxic Epiphytic Benthic Dinoflagellate

(2014) Santiago Fraga et al.   PROTIST

In vivo and in vitro effects of 42-hydroxy-palytoxin on mouse skeletal muscle: Structural and functional impairment

(2014) Giorgia Del Favero et al.   TOXICOLOGY LETTERS

Colorimetric microtiter plate receptor-binding assay for the detection of freshwater and marine neurotoxins targeting the nicotinic acetylcholine receptors

(2014) Fernando Rubio et al.   TOXICON

Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

(2014) Vaishali Bane et al.   Toxins

Translocation of PKC by Yessotoxin in an in Vitro Model of Alzheimer’s Disease with Improvement of Tau and β-Amyloid Pathology

(2013) Eva Alonso et al.   ACS Chemical Neuroscience

Automated, high performance, flow-through chemiluminescence microarray for the multiplexed detection of phycotoxins

(2013) Agathe Szkola et al.   ANALYTICA CHIMICA ACTA

Innovative detection methods for aquatic algal toxins and their presence in the food chain

(2013) Natalia Vilariño et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Multidetection of Paralytic, Diarrheic, and Amnesic Shellfish Toxins by an Inhibition Immunoassay Using a Microsphere-Flow Cytometry System

(2013) María Fraga et al.   ANALYTICAL CHEMISTRY

Selection and Identification of DNA Aptamers against Okadaic Acid for Biosensing Application

(2013) Shimaa Eissa et al.   ANALYTICAL CHEMISTRY

Yessotoxin induces ER-stress followed by autophagic cell death in glioma cells mediated by mTOR and BNIP3

(2013) J.A. Rubiolo et al.   CELLULAR SIGNALLING

Benefit of 13-desmethyl Spirolide C Treatment in Triple Transgenic Mouse Model of Alzheimer Disease: Beta-Amyloid and Neuronal Markers Improvement

(2013) Eva Alonso et al.   Current Alzheimer Research

Automated Solid-Phase Extraction Approaches for Large Scale Biomonitoring Studies

(2013) Z. Kuklenyik et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state

(2013) Ivan Kopljar et al.   JOURNAL OF GENERAL PHYSIOLOGY

Use of Okadaic Acid to Identify Relevant Phosphoepitopes in Pathology: A Focus on Neurodegeneration

(2013) Miguel Medina et al.   Marine Drugs

Okadaic Acid: More than a Diarrheic Toxin

(2013) Vanessa Valdiglesias et al.   Marine Drugs

Okadaic acid induced neurotoxicity: An emerging tool to study Alzheimer's disease pathology

(2013) Pradip K. Kamat et al.   NEUROTOXICOLOGY

Development and validation of the first high performance-lateral flow immunoassay (HP-LFIA) for the rapid screening of domoic acid from shellfish extracts

(2013) Waqass Jawaid et al.   TALANTA

Toxicity of palytoxin after repeated oral exposure in mice and in vitro effects on cardiomyocytes

(2013) Giorgia Del Favero et al.   TOXICON

High-throughput receptor-based assay for the detection of spirolides by chemiluminescence

(2013) Laura P. Rodríguez et al.   TOXICON

Acute toxicities of saxitoxin, neosaxitoxin, decarbamoyl saxitoxin and gonyautoxins 1&4 and 2&3 to mice by various routes of administration

(2013) Rex Munday et al.   TOXICON

Pinnatoxin G is responsible for atypical toxicity in mussels (Mytilus galloprovincialis) and clams (Venerupis decussata) from Ingril, a French Mediterranean lagoon

(2013) Philipp Hess et al.   TOXICON

Is Protein Phosphatase Inhibition Responsible for the Toxic Effects of Okadaic Acid in Animals?

(2013) Rex Munday   Toxins

Collaborative study for the detection of toxic compounds in shellfish extracts using cell-based assays. Part II: application to shellfish extracts spiked with lipophilic marine toxins

(2012) Aurélie Ledreux et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Collaborative study for the detection of toxic compounds in shellfish extracts using cell-based assays. Part I: screening strategy and pre-validation study with lipophilic marine toxins

(2012) Anne-Laure Sérandour et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Lateral-flow immunoassays for mycotoxins and phycotoxins: a review

(2012) Laura Anfossi et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Coupling the Torpedo Microplate-Receptor Binding Assay with Mass Spectrometry to Detect Cyclic Imine Neurotoxins

(2012) Rómulo Aráoz et al.   ANALYTICAL CHEMISTRY

High-Throughput Multiplexed Competitive Immunoassay for Pollutants Sensing in Water

(2012) Cloé Desmet et al.   ANALYTICAL CHEMISTRY

Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells

(2012) Irina Vetter et al.   BIOCHEMICAL PHARMACOLOGY

A Perspective on the Toxicology of Marine Toxins

(2012) Luis M. Botana   CHEMICAL RESEARCH IN TOXICOLOGY

Unique Toxin Profile of a Mediterranean Ostreopsis cf. ovata Strain: HR LC-MSn Characterization of Ovatoxin-f, a New Palytoxin Congener

(2012) Patrizia Ciminiello et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Marine Algal Toxin Azaspiracid Is an Open-State Blocker of hERG Potassium Channels

(2012) Michael J. Twiner et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling

(2012) Irina Vetter et al.   EMBO JOURNAL

Towards the standardisation of the neuroblastoma (neuro-2a) cell-based assay for ciguatoxin-like toxicity detection in fish: application to fish caught in the Canary Islands

(2012) A. Caillaud et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Quantitative proteomic analysis of okadaic acid treated mouse small intestines reveals differentially expressed proteins involved in diarrhetic shellfish poisoning

(2012) Juan Wang et al.   Journal of Proteomics

Design and Synthesis of Skeletal Analogues of Gambierol: Attenuation of Amyloid-β and Tau Pathology with Voltage-Gated Potassium Channel and N-Methyl-d-aspartate Receptor Implications

(2012) Eva Alonso et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Comparative study of toxicological and cell cycle effects of okadaic acid and dinophysistoxin-2 in primary rat hepatocytes

(2012) J.A. Rubiolo et al.   LIFE SCIENCES

Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7)

(2012) J. R. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Study of possible combined toxic effects of azaspiracid-1 and okadaic acid in mice via the oral route

(2012) Tore Aune et al.   TOXICON

Cytotoxicity of yessotoxin and okadaic acid in mouse T lymphocyte cell line EL-4

(2012) Alicia Martín-López et al.   TOXICON

Single Laboratory Validation of A Ready-to-Use Phosphatase Inhibition Assay for Detection of Okadaic Acid Toxins

(2012) Henry G. F. Smienk et al.   Toxins

Solid-Phase Receptor-Based Assay for the Detection of Cyclic Imines by Chemiluminescence, Fluorescence, or Colorimetry

(2011) Laura P. Rodríguez et al.   ANALYTICAL CHEMISTRY

Effect of Uncontrolled Factors in a Validated Liquid Chromatography–Tandem Mass Spectrometry Method Question Its Use As a Reference Method for Marine Toxins: Major Causes for Concern

(2011) Paz Otero et al.   ANALYTICAL CHEMISTRY

Determination of Toxicity Equivalent Factors for Paralytic Shellfish Toxins by Electrophysiological Measurements in Cultured Neurons

(2011) Sheila Perez et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A multicentre open-label safety and efficacy study of tetrodotoxin for cancer pain

(2011) N. A. Hagen et al.   Current Oncology

Transcellular transport of domoic acid across intestinal Caco-2 cell monolayers

(2011) Osamu Kimura et al.   FOOD AND CHEMICAL TOXICOLOGY

Total Synthesis of Pinnatoxins A and G and Revision of the Mode of Action of Pinnatoxin A

(2011) Romulo Araoz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetrodotoxin-Bupivacaine-Epinephrine Combinations for Prolonged Local Anesthesia

(2011) Charles B. Berde et al.   Marine Drugs

Cell death assays for drug discovery

(2011) Oliver Kepp et al.   NATURE REVIEWS DRUG DISCOVERY

13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro

(2011) Eva Alonso et al.   NEUROCHEMISTRY INTERNATIONAL

Yessotoxin as an apoptotic inducer

(2011) Mónica Suárez Korsnes et al.   TOXICON

Investigations into the Toxicology of Spirolides, a Group of Marine Phycotoxins

(2011) Rex Munday et al.   Toxins

The opening of maitotoxin-sensitive calcium channels induces the acrosome reaction in human spermatozoa: differences from the zona pellucida

(2010) Julio C Chávez et al.   ASIAN JOURNAL OF ANDROLOGY

Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin

(2010) Chong Hyun Lee et al.   Channels

Health impact of unicellular algae of theOstreopsisgenus blooms in the Mediterranean Sea: experience of the French Mediterranean coast surveillance network from 2006 to 2009

(2010) Lucia Tichadou et al.   CLINICAL TOXICOLOGY

Naturally contaminated shellfish samples: quantification of diarrhetic shellfish poisoning toxins in unhydrolysed and hydrolysed extracts and cytotoxicity assessment

(2010) Susana M. Rodrigues et al.   JOURNAL OF APPLIED TOXICOLOGY

Targets and Effects of Yessotoxin, Okadaic Acid and Palytoxin: A Differential Review

(2010) Antonella Franchini et al.   Marine Drugs

Palytoxin and Analogs: Biological and Ecological Effects

(2010) Vítor Ramos et al.   Marine Drugs

Cell-Based Assays for High-Throughput Screening

(2010) W. Frank An et al.   MOLECULAR BIOTECHNOLOGY

Assessment of okadaic acid effects on cytotoxicity, DNA damage and DNA repair in human cells

(2010) Vanessa Valdiglesias et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Involvement of Caspase Activation in Azaspiracid-Induced Neurotoxicity in Neocortical Neurons

(2010) Zhengyu Cao et al.   TOXICOLOGICAL SCIENCES

Global distribution of ciguatera causing dinoflagellates in the genus Gambierdiscus

(2010) R. Wayne Litaker et al.   TOXICON

Sub-lethal dosing of azaspiracid-1 in female NMRI mice

(2010) John A.B. Aasen et al.   TOXICON

Palytoxin action on the Na+,K+-ATPase and the disruption of ion equilibria in biological systems

(2010) Gian Paolo Rossini et al.   TOXICON

Occurrence of palytoxin-group toxins in seafood and future strategies to complement the present state of the art

(2010) Katerina Aligizaki et al.   TOXICON

The problem of toxicity equivalent factors in developing alternative methods to animal bioassays for marine-toxin detection

(2010) Luis M. Botana et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

A European perspective on progress in moving away from the mouse bioassay for marine-toxin analysis

(2010) Katrina Campbell et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Feasibility of gymnodimine and 13-desmethyl C spirolide detection by fluorescence polarization using a receptor-based assay in shellfish matrixes

(2009) Eva S. Fonfría et al.   ANALYTICA CHIMICA ACTA

The methyl ester of okadaic acid is more potent than okadaic acid in disrupting the actin cytoskeleton and metabolism of primary cultured hepatocytes

(2009) Begoña Espiña et al.   BRITISH JOURNAL OF PHARMACOLOGY

Monoclonal Antibodies with Orthogonal Azaspiracid Epitopes

(2009) Michael O. Frederick  et al.   CHEMBIOCHEM

A Structural Basis for the Reduced Toxicity of Dinophysistoxin-2

(2009) Jason Huhn et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Ion channels in T lymphocytes: An update on facts, mechanisms and therapeutic targeting in autoimmune diseases

(2009) Zoltan Varga et al.   IMMUNOLOGY LETTERS

Palytoxin Poisoning After Dermal Contact with Zoanthid Coral

(2009) Sean Patrick Nordt et al.   JOURNAL OF EMERGENCY MEDICINE

Proteomic response of human neuroblastoma cells to azaspiracid-1

(2009) Ralf Kellmann et al.   Journal of Proteomics

Potentiation of Local Anesthetic Activity of Neosaxitoxin with Bupivacaine or Epinephrine: Development of a Long-Acting Pain Blocker

(2009) Alberto J. Rodriguez-Navarro et al.   NEUROTOXICITY RESEARCH

Effects of pre-emptive drug treatment on astrocyte activation in the cuneate nucleus following rat median nerve injury

(2009) Jiann-Jy Chen et al.   PAIN

Palytoxin toxicity after acute oral administration in mice

(2009) S. Sosa et al.   TOXICOLOGY LETTERS

First report on toxicity assessment of the Lessepsian migrant pufferfish Lagocephalus sceleratus (Gmelin, 1789) from European waters (Aegean Sea, Greece)

(2009) Panagiota Katikou et al.   TOXICON

Development of a monoclonal antibody binding okadaic acid and dinophysistoxins-1, -2 in proportion to their toxicity equivalence factors

(2009) Linda D. Stewart et al.   TOXICON

Azaspiracid poisoning (AZP) toxins in shellfish: Toxicological and health considerations

(2009) Ambrose Furey et al.   TOXICON

Domoic acid and human exposure risks: A review

(2009) Kathi A. Lefebvre et al.   TOXICON

Yessotoxins: A toxicological overview

(2009) A. Tubaro et al.   TOXICON

Functional assays for marine toxins as an alternative, high-throughput-screening solution to animal tests

(2009) Luis M. Botana et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Chemiluminescent enzyme immunoassays: a review of bioanalytical applications

(2009) Christophe A Marquette et al.   Bioanalysis

First Toxicity Report of Tetrodotoxin and 5,6,11-TrideoxyTTX in the Trumpet Shell Charonia lampas lampas in Europe

(2008) Paula Rodriguez et al.   ANALYTICAL CHEMISTRY

Specific and dynamic detection of palytoxins by in vitro microplate assay with human neuroblastoma cells

(2008) Begoña Espiña et al.   BIOSCIENCE REPORTS

Enzymatic recycling-based amperometric immunosensor for the ultrasensitive detection of okadaic acid in shellfish

(2008) Mònica Campàs et al.   BIOSENSORS & BIOELECTRONICS

Subcutaneous tetrodotoxin and inflammatory pain

(2008) L.F. Alguacil et al.   BRITISH JOURNAL OF ANAESTHESIA

Cytoskeletal toxicity of pectenotoxins in hepatic cells

(2008) B Espiña et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cytotoxic effect of azaspiracid-2 and azaspiracid-2-methyl ester in cultured neurons: Involvement of the c-Jun N-terminal kinase

(2008) Carmen Vale et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Azaspiracid Shellfish Poisoning: A Review on the Chemistry, Ecology, and Toxicology with an Emphasis on Human Health Impacts

(2008) Michael Twiner et al.   Marine Drugs

Non-Traditional Vectors for Paralytic Shellfish Poisoning

(2008) Jonathan Deeds et al.   Marine Drugs

A nomenclature for ligand-gated ion channels

(2008) Graham L. Collingridge et al.   NEUROPHARMACOLOGY

Confirmation by LC–MS/MS of azaspiracids in shellfish from the Portuguese north-western coast

(2008) Paulo Vale et al.   TOXICON

Effects of cooking and heat treatment on concentration and tissue distribution of okadaic acid and dinophysistoxin-2 in mussels (Mytilus edulis)

(2008) Pearse McCarron et al.   TOXICON

Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels

(2008) Eva Cuypers et al.   TOXICON

Comparative study of the use of neuroblastoma cells (Neuro-2a) and neuroblastoma×glioma hybrid cells (NG108-15) for the toxic effect quantification of marine toxins

(2008) Elisabeth Cañete et al.   TOXICON

Comparative toxicity to mice of domoic acid and isodomoic acids A, B and C

(2008) Rex Munday et al.   TOXICON

In vitro approaches to evaluate palytoxin-induced toxicity and cell death in intestinal cells

(2007) I. Valverde et al.   JOURNAL OF APPLIED TOXICOLOGY

Shellfish consumption: A major risk factor for colorectal cancer

(2007) Emilia Manerio et al.   MEDICAL HYPOTHESES

Novel symptomatology and changing epidemiology of domoic acid toxicosis in California sea lions (Zalophus californianus): an increasing risk to marine mammal health

(2007) T Goldstein et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

First episode of shellfish contamination by palytoxin-like compounds from Ostreopsis species (Aegean Sea, Greece)

(2007) Katerina Aligizaki et al.   TOXICON