Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies

Protonation state of inhibitors determines interaction sites within voltage-gated sodium channels

(2018) Amanda Buyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spider toxin inhibits gating pore currents underlying periodic paralysis

(2018) Roope Männikkö et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progress in Understanding and Treating SCN2A -Mediated Disorders

(2018) Stephan J. Sanders et al.   TRENDS IN NEUROSCIENCES

Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants

(2017) Denis B. Tikhonov et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET

(2017) Tomoya Kubota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

(2017) Huaizong Shen et al.   SCIENCE

Structure-based assessment of disease-related mutations in human voltage-gated sodium channels

(2017) Weiyun Huang et al.   Protein & Cell

Molecular basis of ion permeability in a voltage‐gated sodium channel

(2016) Claire E Naylor et al.   EMBO JOURNAL

Saxitoxin

(2014) Arun P. Thottumkara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sodium Channels, Inherited Epilepsy, and Antiepileptic Drugs

(2014) William A. Catterall   Annual Review of Pharmacology and Toxicology

Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity

(2014) Brad R Green et al.   Future Medicinal Chemistry

Folding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4

(2014) Viacheslav S. Korkosh et al.   JOURNAL OF GENERAL PHYSIOLOGY

Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel

(2014) C. Boiteux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular Organization of α-Toxins from Scorpion Venom Mirrors Domain Structure of Their Targets, Sodium Channels

(2013) Anton O. Chugunov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a)

(2013) Natali A. Minassian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition

(2013) Stefanie Marzian et al.   Nature Chemical Biology

Distinct Disulfide Isomers of μ-Conotoxins KIIIA and KIIIB Block Voltage-Gated Sodium Channels

(2012) Keith K. Khoo et al.   BIOCHEMISTRY

Design of Bioactive Peptides from Naturally Occurring μ-Conotoxin Structures

(2012) Marijke Stevens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping the Interaction Site for a β-Scorpion Toxin in the Pore Module of Domain III of Voltage-gated Na+Channels

(2012) Joel Z. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-gated sodium channels at 60: structure, function and pathophysiology

(2012) William A. Catterall   JOURNAL OF PHYSIOLOGY-LONDON

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

(2012) Xu Zhang et al.   NATURE

Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7)

(2012) J. R. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular mystique of tetrodotoxin

(2012) Edward G. Moczydlowski   TOXICON

Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity

(2011) Annelies Van Der Haegen et al.   FEBS Journal

Identification of New Batrachotoxin-sensing Residues in Segment IIIS6 of the Sodium Channel

(2011) Yuzhe Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Map of the Receptor Site for β-Scorpion Toxins in Domain II of Voltage-gated Sodium Channels

(2011) Joel Z. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orientation of  -Conotoxin PIIIA in a Sodium Channel Vestibule, Based on Voltage Dependence of Its Binding

(2011) J. R. McArthur et al.   MOLECULAR PHARMACOLOGY

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Mapping the receptor site for  -scorpion toxins on a Na+ channel voltage sensor

(2011) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve

(2011) M. J. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple, Distributed Interactions of μ-Conotoxin PIIIA Associated with Broad Targeting among Voltage-Gated Sodium Channels

(2010) Jeff R. McArthur et al.   BIOCHEMISTRY

Unexpected synergism between Tetrodotoxin and μ-conotoxin in blocking voltage-gated sodium channels

(2010) Min Min Zhang et al.   Channels

The Tetrodotoxin Binding Site Is within the Outer Vestibule of the Sodium Channel

(2010) Harry A. Fozzard et al.   Marine Drugs

Potassium Channel Block by a Tripartite Complex of Two Cationophilic Ligands and a Potassium Ion

(2010) P. I. Zimin et al.   MOLECULAR PHARMACOLOGY

Targeting voltage sensors in sodium channels with spider toxins

(2010) Frank Bosmans et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels NaV1.2, 1.6 and 1.7

(2008) Brian Fiedler et al.   BIOCHEMICAL PHARMACOLOGY

Toxin-Resistant Sodium Channels: Parallel Adaptive Evolution across a Complete Gene Family

(2008) M. C. Jost et al.   MOLECULAR BIOLOGY AND EVOLUTION

Access and Binding of Local Anesthetics in the Closed Sodium Channel

(2008) I. Bruhova et al.   MOLECULAR PHARMACOLOGY